Grey and White Matter

Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton  

Introduction[edit | edit source]

Grey and white matter Human brain

The central nervous system is made up of grey matter and white matter.

  1. Gray matter: named for its pinkish-gray color, is home to neural cell bodies, axon terminals, and dendrites, as well as all nerve synapses. This brain tissue is abundant in the cerebellum, cerebrum, and brain stem. It also forms a butterfly-shaped portion of the central spinal cord.
  2. White matter: composed of bundles of axons. These axons are coated with myelin, a mixture of proteins and lipids, that helps conduct nerve signals and protect the axons. White matter conducts, processes, and send nerve signals up and down the spinal cord[1].

Gray Matter[edit | edit source]

Basal ganglia

Grey matter makes up the outer most layer of the brain.

  1. The grey matter surrounding the cerebrum is known as the cortex of the brain. There are two major cortexes in the brain, the cerebral cortex and the cerebellar cortex. Interestingly the highest concentration of neuronal cells is in the cerebellum, which has more than the rest of the brain combined.
  2. There are also areas of grey matter that are in the inner sections of the brain known as or nuclei. eg Basal Ganglia

The grey matter has a large number of neurons present, which allows it to process information and release new information through axon signaling found in the white matter. The grey matter throughout the central nervous system allows enables individuals to control movement, memory, and emotions. Different areas of the brain are responsible for various functions, and grey matter plays a significant role in all aspects of human life.

Spinal cord – section

In the spinal cord the gray matter forms a “butterfly” structure with an anterior horn, the lateral horn and the posterior horn. The three sections sections give rise to the anterolateral columns, the lateral grey column and the dorsal columns[2].

  1. Anterolateral columns (important for all motor movements)
  2. Lateral columns (responsible for regulating the autonomic nervous system through its role in activating the sympathetic nervous system)
  3. Dorsal columns (receives sensory signals allowing for constant interaction between the environment and the body)[2][3]

See Central Nervous System Pathways for details

White Matter[edit | edit source]

White Matter Connections Obtained with MRI Tractography

White matter is a vast, intertwining system of neural connections. White matter refers to areas of the brain where there is a preponderance of axons coated with myelin. Axons, which can be up to three feet long, are the longest projections of brain cells and carry a cell’s signal to other cells.

  1. Microscopic level: white matter consists of millions of closely packed axons, each wrapped concentrically in a myelin sheath, an insulation made up of roughly 70 percent lipid and 30 percent protein. It is this fatty insulation that gives these areas of the brain a whitish hue.
  2. Macroscopically: forms various kinds of fiber collections, eg projection fibers, association fibers, commissural fibers. Most critical for the higher functions of the brain are the association fibers, which travel within the individual cerebral hemispheres, and the commissural fibers, which connect the left and right hemispheres. An abundance of white matter is a striking feature of the frontal regions of the brain. These lobes have the highest degree of connectivity of any brain lobe[4].

Matter across the Brain's Age Span[edit | edit source]

Cellular basis of IQ

Throughout development

  • Grey matter volume increases until around the age of 8. After year eight, the grey matter begins to decrease in areas of the brain, but the density of the grey matter in particular increases.
  • White matter: We do not complete the formation of brain myelin until many years after birth, perhaps past 20 years of age.

In an autopsy study of normal brains from age 20 to 90,

  1. White matter loss (by volume) was 28 percent
  2. Neocortical (gray matter) loss, was 12 percent.

This greater loss of white matter, with its special role in connectivity and efficient brain communication, suggests a cause for slowed speed in information processing, diminished attentional capacity, and forgetfulness, all typical cognitive changes of aging[1].

Physiotherapy Implications[edit | edit source]

Intensive Care Unit

Many issues may affect the grey matter found in the brain and the spinal cord. Some are listed below:

  • One of the most prevalent medical problems occurs when plaque begins to build up in areas of grey matter within the brain. These areas, known as senile plaques, take up space that was once grey matter, leading to a decrease of higher functioning. Senile plaques and neurofibrillary tangles are the principal histopathologic hallmarks of Alzheimer disease.[5]
  • As the neurons in the substantia nigra begin to decrease the amount of dopamine that is released, the individual will lose control of fine motor skills. This decrease in motor function control contributes to the shaking found in patients with Parkinson disease.
  • Trauma: neuronal cells of the grey matter are constantly working and require a high supply of oxygen to function efficiently.  Grey matter with no access to oxygen will begin to die, leading to possible irreversible brain damage and loss of function.
  • Blunt force trauma eg causing the grey matter to become damaged (due to an intracerebral hemorrhage) can lead to apoptosis of the grey matter cells[2].

Many issues also may affect the cerebral white matter: disorders can be genetic, demyelinative, infectious, inflammatory, toxic, metabolic, vascular, traumatic, neoplastic, and hydrocephalic. Examples include:

  • MS
  • Infectious diseases that induce cognitive decline do so, in part, by affecting the white matter. Prominent among these diseases is the acquired immune deficiency syndrome (AIDS) dementia complex.
  • Noninfectious inflammatory diseases eg systemic lupus erythematosus can affect the white matter by immune-related processes, and the multiple manifestations of neuropsychiatric lupus are increasingly recognized.
  • A large and growing number of white matter toxins have been identified eg common solvent toluene. Detailed MRI studies of toluene leukoencephalopathy in solvent abusers disclosed dramatic white matter disease that correlates with the severity of dementia produced.
  • Traumatic brain injury also qualifies as a white matter disorder, because patients with brain trauma often have a white matter lesion known as diffuse axonal injury.
Pathophysiology of Secondary Cerebral Damage after Traumatic Brain Injury

References[edit | edit source]

  1. 1.0 1.1 Spinalcord Gray vs white matter Available:https://www.spinalcord.com/blog/gray-matter-vs-white-matter-in-the-brain (accessed 1.5.2022)
  2. 2.0 2.1 2.2 Mercadante AA, Tadi P. Neuroanatomy, Gray Matter.2020 Available:https://www.ncbi.nlm.nih.gov/books/NBK553239/ (accessed 1.5.2022)
  3. Radiopedia White matter tracts Spinal cord Available:https://radiopaedia.org/articles/white-matter-tracts-of-the-spinal-cord (accessed 1.5.2022)
  4. Dana org Why the white brain matters Available:https://www.dana.org/article/why-the-white-brain-matters/ (accessed 1.5.2022)
  5. Walker LC. Prion-like mechanisms in Alzheimer disease. Handbook of clinical neurology. 2018 Jan 1;153:303-19. Available:https://www.sciencedirect.com/topics/medicine-and-dentistry/senile-plaques (accessed 1.5.2022)