Total Knee Arthroplasty: Difference between revisions

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== Definition/Description  ==
== Definition/Description  ==
[[Image:Total knee arthroplasty.jpg|right]]Total knee arthroplasty (TKA) or total knee replacement (TKR) is a common orthopaedic surgery that involves replacing the articular surfaces (femoral condyles and tibial plateau) of the [[Knee|knee joint]] with smooth metal and polyethylene plastic.<ref name=":2">Evans JT, Walker RW, Evans JP, Blom AW, Sayers A, Whitehouse MR. [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32531-5/fulltext How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up]. The Lancet. 2019 Feb 16;393(10172):655-63.</ref><ref>Palmer, S., 2020. Total Knee Arthroplasty (TKA). [online] Medscape. Available at: <[https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis. https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis.>] [Accessed 22 December 2020].</ref> TKA aims to improve the quality of life of individuals with end-stage [[Knee Osteoarthritis|osteoarthritis]] by reducing pain and increasing function.<ref name=":2" /> The number of TKA surgeries has increased in developed countries,<ref>Jakobsen TL, Jakobsen MD, Andersen LL, Husted H, Kehlet H, Bandholm T. [https://pubmed.ncbi.nlm.nih.gov/31267365/ Quadriceps muscle activity during commonly used strength training exercises shortly after total knee arthroplasty: implications for home-based exercise-selection.] Journal of experimental orthopaedics. 2019 Dec 1;6(1):29.</ref> with younger patients receiving TKA.<ref>Scott CE, Oliver WM, MacDonald D, Wade FA, Moran M, Breusch SJ. P[https://www.researchgate.net/publication/311342546_Predicting_dissatisfaction_following_total_knee_arthroplasty_in_patients_under_55_years_of_age redicting dissatisfaction following total knee arthroplasty in patients under 55 years of age]. The bone & joint journal. 2016 Dec;98(12):1625-34.</ref>   
[[Image:Total knee arthroplasty.jpg|80x80px|right]]Total knee arthroplasty (TKA) or total knee replacement (TKR) is a common orthopaedic surgery that involves replacing the articular surfaces (femoral condyles and tibial plateau) of the [[Knee|knee joint]] with smooth metal and polyethylene plastic.<ref name=":2">Evans JT, Walker RW, Evans JP, Blom AW, Sayers A, Whitehouse MR. [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32531-5/fulltext How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up]. The Lancet. 2019 Feb 16;393(10172):655-63.</ref><ref>Palmer, S., 2020. Total Knee Arthroplasty (TKA). [online] Medscape. Available at: <[https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis. https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis.>] [Accessed 22 December 2020].</ref> TKA aims to improve the quality of life of individuals with end-stage [[Knee Osteoarthritis|osteoarthritis]] by reducing pain and increasing function.<ref name=":2" /> The number of TKA surgeries has increased in developed countries,<ref>Jakobsen TL, Jakobsen MD, Andersen LL, Husted H, Kehlet H, Bandholm T. [https://pubmed.ncbi.nlm.nih.gov/31267365/ Quadriceps muscle activity during commonly used strength training exercises shortly after total knee arthroplasty: implications for home-based exercise-selection.] Journal of experimental orthopaedics. 2019 Dec 1;6(1):29.</ref> with younger patients receiving TKA.<ref>Scott CE, Oliver WM, MacDonald D, Wade FA, Moran M, Breusch SJ. P[https://www.researchgate.net/publication/311342546_Predicting_dissatisfaction_following_total_knee_arthroplasty_in_patients_under_55_years_of_age redicting dissatisfaction following total knee arthroplasty in patients under 55 years of age]. The bone & joint journal. 2016 Dec;98(12):1625-34.</ref>   


There is at least one polyethylene piece, placed between the [[tibia]] and the [[femur]] as a shock absorber.<ref name=":4">Medscape. Total knee arthroplasty (TKA). Available from: https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis. (accessed 28/07/2020).</ref> The prostheses are usually reinforced with cement, but may be left uncemented where bone growth is relied upon to reinforce the components. The patella may be replaced or resurfaced.<ref>Maney AJ, Koh CK, Frampton CM, Young SW. [https://journals.lww.com/jbjsjournal/subjects/Knee/Abstract/2019/03060/Usually,_Selectively,_or_Rarely_Resurfacing_the.5.aspx Usually, selectively, or rarely resurfacing the patella during primary total knee arthroplasty: determining the best strategy]. JBJS. 2019 Mar 6;101(5):412-20.</ref><ref name=":3" /> Patella reconstruction aims to restore the extensor mechanism. During [[Surgery and General Anaesthetic|surgery]], a quadriceps-splitting or quadriceps-sparing approach may be used,<ref>Berstock JR, Murray JR, Whitehouse MR, Blom AW, Beswick AD. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890136/ Medial subvastus versus the medial parapatellar approach for total knee replacement: a systematic review and meta-analysis of randomized controlled trials]. EFORT open reviews. 2018 Mar;3(3):78-84.</ref> and the cruciate ligaments may be excised or preserved.  
There is at least one polyethylene piece, placed between the [[tibia]] and the [[femur]] as a shock absorber.<ref name=":4">Medscape. Total knee arthroplasty (TKA). Available from: https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis. (accessed 28/07/2020).</ref> The prostheses are usually reinforced with cement, but may be left uncemented where bone growth is relied upon to reinforce the components. The patella may be replaced or resurfaced.<ref>Maney AJ, Koh CK, Frampton CM, Young SW. [https://journals.lww.com/jbjsjournal/subjects/Knee/Abstract/2019/03060/Usually,_Selectively,_or_Rarely_Resurfacing_the.5.aspx Usually, selectively, or rarely resurfacing the patella during primary total knee arthroplasty: determining the best strategy]. JBJS. 2019 Mar 6;101(5):412-20.</ref><ref name=":3" /> Patella reconstruction aims to restore the extensor mechanism. During [[Surgery and General Anaesthetic|surgery]], a quadriceps-splitting or quadriceps-sparing approach may be used,<ref>Berstock JR, Murray JR, Whitehouse MR, Blom AW, Beswick AD. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890136/ Medial subvastus versus the medial parapatellar approach for total knee replacement: a systematic review and meta-analysis of randomized controlled trials]. EFORT open reviews. 2018 Mar;3(3):78-84.</ref> and the cruciate ligaments may be excised or preserved.  
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===== '''Common Bed and Chair Exercises''' =====
===== '''Common Bed and Chair Exercises''' =====
Video link: <ref>UnityPoint Health - Cedar Rapids. Knee replacement exercise video for UnityPoint Health - St. Luke's Hospital patients [Internet]. 2020 [cited 22 December 2020]. Available from: https://www.youtube.com/watch?v=nM0K5MlQc3U</ref>
{{#ev:youtube|nM0K5MlQc3U}} <ref>UnityPoint Health - Cedar Rapids. Knee replacement exercise video for UnityPoint Health - St. Luke's Hospital patients [Internet]. 2020 [cited 22 December 2020]. Available from: https://www.youtube.com/watch?v=nM0K5MlQc3U</ref>
* Ankle plantarflexion/dorsiflexion
* Ankle plantarflexion/dorsiflexion
* Isometric knee extension in outer range
* Isometric knee extension in outer range

Revision as of 06:00, 3 January 2021

Definition/Description[edit | edit source]

Total knee arthroplasty.jpg

Total knee arthroplasty (TKA) or total knee replacement (TKR) is a common orthopaedic surgery that involves replacing the articular surfaces (femoral condyles and tibial plateau) of the knee joint with smooth metal and polyethylene plastic.[1][2] TKA aims to improve the quality of life of individuals with end-stage osteoarthritis by reducing pain and increasing function.[1] The number of TKA surgeries has increased in developed countries,[3] with younger patients receiving TKA.[4]

There is at least one polyethylene piece, placed between the tibia and the femur as a shock absorber.[5] The prostheses are usually reinforced with cement, but may be left uncemented where bone growth is relied upon to reinforce the components. The patella may be replaced or resurfaced.[6][7] Patella reconstruction aims to restore the extensor mechanism. During surgery, a quadriceps-splitting or quadriceps-sparing approach may be used,[8] and the cruciate ligaments may be excised or preserved.

There are different types of surgical approaches, designs, and fixations.[5][9] A unicondylar knee replacement (UKR)[10] or patellofemoral replacement (PFR) may also be performed depending on the extent of disease.[1]

[7]

Several options of anaesthesia are available, and include regional anaesthesia in combination with local infiltration anaesthesia, or general anaesthesia in combination with local infiltration anaesthesia, with the possible addition of peripheral nerve blocks to either option.[11] A tourniquet may sometimes be used during surgery.[12] Computer-assisted navigation systems have been introduced in TKA surgery, and prospective studies on long term functional outcomes are needed.[13]

Clinically Relevant Anatomy[edit | edit source]

The most important structures of the knee

The Knee is a modified hinge joint that allows flexion and extension motions, with slight amounts of internal and external rotation. Three bones form the knee joint: the upper part of the tibia, the lower part of the femur and the patella. The articular surfaces are covered with a thin layer of cartilage. Meniscii adhere to the lateral and medial surfaces of the tibial plateau and aids in shock absorption. The knee joint is reinforced by ligaments and a joint capsule.

Epidemiology /Etiology[edit | edit source]

The most common indication for a primary knee replacement, TKA, is osteoarthritis.[1] Osteoarthritis causes the cartilage of the joint to become damaged and no longer able to absorb shock. Risk factors for knee osteoarthritis include gender, increased body mass index, history of knee injury and comorbidities.[14][15] Pain is the main complaint of patients' with knee osteoarthritis.[16] Pain is subjective, involves peripheral and central neural mechanisms that are modulated by neurochemical, environmental, psychological and genetic factors. [16]

Total knee arthroplasty is more commonly performed on women and individuals of older ages.[5][17] In both the US and UK, majority of TKA surgeries were performed on women.[5][18] Dramatic increases in TKA surgeries are projected to occur[18] with an increasing rate of younger TKA recipients under the age of 60.[19]

Diagnostic Procedures[edit | edit source]

Before a TKA surgery, a full medical evaluation is performed to determine risks and suitability. As part of this evaluation, imaging is used to assess the severity of joint degeneration and screen for other joint abnormalities.[20] A knee radiograph is performed to check for prosthetic alignment before closure of the surgical incision.[7]

Pre-surgical Physiotherapy[edit | edit source]

Post-surgical rehabilitation exercises may be taught before surgery, so that patients may perform the appropriate exercises more effectively immediately after TKA surgery.  A pre-surgical training programme may also be used to optimize functional status of patients to improve post-surgical recovery. Pre-surgical training programmes should focus on postural control, functional lower limb exercises and strengthening exercises for bilateral lower extremities.[21]

Evidence supporting the efficacy of pre-surgical physiotherapy on patient outcome scores, lower limb strength, pain, range of movement or hospital length of stay following total knee arthroplasty is lacking.[22][23][24][25]

Post-TKA Surgery[edit | edit source]

Majority of individuals begin physiotherapy during their inpatient stay, within 24 hours after TKA surgery, which typically lasts 1 to 2 hours.[20] Range of motion and strengthening exercises, cryotherapy and gait training are typically initiated, and a home exercise programme prescribed before discharge from hospital. There is low-level evidence that accelerated physiotherapy regimens reduce acute hospital length of stay.[26]

Patients are usually discharged after a few days’ stay in hospital and receive follow-up physiotherapy in the outpatient or home care setting within 1 week.[27]

The following post-operative guidelines for assessment and management are intended for individuals who have undergone primary TKA surgery with cemented prosthesis, using a standard surgical approach. Surgeons’ instructions should always be followed.

Post-surgical Physiotherapy[edit | edit source]

Subjective Assessment[edit | edit source]

Assessment should include, and is not limited to:

Operative and post-operative complications, if any

    • History of knee and other musculoskeletal complaints, if any
    • Past medical history and relevant comorbidities
    • Social factors and home set-up
    • Progress in home exercises post-TKA surgery
    • Pain and other symptoms/ discomfort (e.g. numbness, swelling)
    • Expectations from surgery and rehabilitation
    • Specific functional goals

Objective Assessment[edit | edit source]

Assessment should include, and is not limited to:

    • Observation of surgical wound or scar
    • Assess for signs of infection: redness, discharge (pus/ odour), adhesions of the skin, abnormal warmth and swelling, expanding redness beyond the edges of the surgical incision, fever or chills. Suspicion of infection warrants medical referral.
    • Knee swelling (circumference)
    • Vital signs and relevant laboratory findings (in the acute setting)
    • Check for deep vein thrombosis (DVT):
      • Homan’s sign test
      • Signs and symptoms of chest pain, shortness of breath, redness or discoloration, heat, deep calf pain or tenderness
      • Suspicion of DVT warrants urgent medical referral
    • Palpation: Check for increased warmth and swelling, as well as muscle activation (e.g. quadriceps; vastus medialis oblique) and hypertonia (e.g. hip adductors)
    • Lower limb range of motion: Active and passive knee range of motion (see treatment milestones for more details) in supine or semi-reclined position
    • Lower limb muscle activation and strength
    • Gait:

Outcome Measures[edit | edit source]

Post-surgical Physiotherapy Treatment Strategies & Goals[edit | edit source]

Phase I: Up to 2-3 weeks post-surgery[27][32][edit | edit source]

    • Patient education: pain science, pain management, importance of home exercises and setting rehabilitation expectations
    • Achieve active and passive knee flexion to 90 degrees with full extension
      • Keep passive knee flexion range of motion testing to <90 degrees in the first 2 weeks to protect surgical incision and respect tissue healing
    • Minimal pain and swelling
    • Achieve full weight bearing
    • Independence in mobility and activities of daily living

During the early phase of rehabilitation, it is important to establish a therapeutic alliance and provide education on pain management strategies. Pain education may include appropriate usage of pain medication, cryotherapy[33] and elevation of the operated limb. Patients should be informed to avoid resting with a pillow under the knee as this may lead to contractures.

There is evidence that cryotherapy improves knee range of motion and pain in the short-term. Icing after exercise may be helpful, but low quality evidence makes specific recommendations for the use of cryotherapy difficult.[34]

Reviewing the patient’s home exercise program (HEP) is also important to do on Day 1. Engaging in their home exercise program is a critical piece of their recovery. Review their post-op exercises given from the surgeon and inpatient Physiotherapist (Sunnybrook Hospital5 has a great resource). In the early phase, stair climbing with the non-operated leg leading on ascent, and the operated leg leading on descent may be encouraged.

Common Bed and Chair Exercises[edit | edit source]

[35]

  • Ankle plantarflexion/dorsiflexion
  • Isometric knee extension in outer range
  • Inner Range Quadriceps strengthening using a pillow or rolled towel behind the knee
  • Knee and hip flexion/extension
  • Isometric buttock contraction
  • Hip abduction/adduction
  • Straight leg raises
  • Bridging

Phase II: 4-6 weeks post-surgery[edit | edit source]

    • No quadriceps lag, with good, voluntary quadriceps muscle control
    • Active knee flexion range of motion to 105 degrees
    • Full knee extension
    • Minimal to no pain and swelling

Physiotherapy sessions may be scheduled once to twice weekly, at six to twelve weeks post-TKA surgery. This frequency may increase or decrease depending on individuals’ progress. Achieving full knee extension is essential for functional tasks such as walking and stair climbing. Knee flexion range of motion is required for comfortable walking (65 degrees), stair climbing (85 degrees), sitting and standing (95 degrees).[36] In this phase, tissue mobilization techniques may be used to improve scar mobility.

Phase III: 6-8 weeks post-surgery[edit | edit source]

    • Strengthening and functional exercises
    • Balance and proprioception training

While primary TKA has been reported to reduce falls incidence[37] and improving balance-related functions such as single limb standing balance,[37][38] the suboptimal recovery of proprioception, sensory orientation, postural control, and strength of the operated limb post-TKA is well documented[37][38][39]. Literature highlights the importance of proprioceptive training, and pre-operative training[39] that involves the non-operated limb[38] may be considered. Balance exercises may include single leg balance, stepping over objects, lateral step-ups, and standing on uneven surfaces. Balance and proprioceptive training that involves single limb standing may begin when adequate knee control is achieved, which typically occurs around 8 weeks post-TKA.[27]

Individualized rehabilitation programs that include strengthening and intensive functional exercises given through land-based or aquatic programs may be progressed as clinical and strength milestones are met. Supervision by a trained physiotherapist is beneficial, owing to the highly individualized characteristics of these exercises.[40][41]

Phase IV: 8-12 weeks, up to 1 year post-surgery[edit | edit source]

    • Independent exercise in community setting
    • Continue regular exercise involving strengthening, balance and proprioception
    • Incorporate strategies for behavior change to increase overall physical activity[42]

Discharge Criteria[edit | edit source]

Discharge planning should be individualized to consider if:

    • A minimum of 110 degrees active knee flexion and full extension is achieved
    • Ambulation goals are achieved
    • Compliance and competency with a home exercise program is achieved
      • Recommend commitment to an independent exercise program over 6-12 months post-operatively, with strength training 2-3 times/ week, to ensure hypertrophy beyond neural adaptation [27]

Complications & Contraindications[edit | edit source]

Following TKA surgery, these complications may occur:

  • Deep vein thrombosis (DVT)
  • Infection
  • Nerve damage
  • Bone fracture (intra-operative or post-operative)
  • Prosthesis-related complications: loosening or fracture of the prosthesis components, joint instability and dislocation, component misalignment and breakdown
  • Stiffness[36]
  • Persistent/ chronic pain[43][44]
  • Falls Risk

DVT is a common complication after knee or hip replacement surgery that can cause significant morbidity and mortality. Incidence of DVT after knee or hip replacement has been reported at 18%,[45] and larger studies have reported that a hypercoagulable diagnosis puts patients at greater risk of a DVT within 6 months of joint replacement surgery.[46]

Stiffness is the most common complaint following primary TKA, affecting approximately 6 to 7% of patients undergoing surgery. [36] Contemporary literature supports defining “acquired idiopathic stiffness” as having a range of motion of  <90° persisting for >12 weeks after primary TKA, in the absence of complicating factors including pre-existing stiffness. Stiffness causes significant functional disability and lower satisfaction.[47] Females and obese patients are reported to be at increased risk.[48]

Evidence does not recommend routine use of continuous passive motion (CPM) as long term clinical and functional effects are insignificant,[49][50] and not superior to traditional mobilisation techniques.[51]

While more research is needed for the long term failure rates of TKA implants, available arthroplasty registry data shows that 82% of TKA surgeries and 70% of unilateral knee replacement surgeries last 25 years in patients with osteoarthritis.[1] Polyethylene wear is a common cause for revision surgery.[1]

High-risk activities that may not be permitted, or require clearance with the orthopaedic surgeon, post-TKA surgery:

  • Singles tennis, squash/racquet ball
  • Jogging
  • High impact aerobics
  • Mountain biking
  • Soccer, football, volleyball, baseball/softball, handball, volleyball, basketball
  • Gymnastics
  • Water-skiing/ water sports
  • Skiing
  • Skating

References[edit | edit source]

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Evans JT, Walker RW, Evans JP, Blom AW, Sayers A, Whitehouse MR. How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up. The Lancet. 2019 Feb 16;393(10172):655-63.
  2. Palmer, S., 2020. Total Knee Arthroplasty (TKA). [online] Medscape. Available at: <https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis.> [Accessed 22 December 2020].
  3. Jakobsen TL, Jakobsen MD, Andersen LL, Husted H, Kehlet H, Bandholm T. Quadriceps muscle activity during commonly used strength training exercises shortly after total knee arthroplasty: implications for home-based exercise-selection. Journal of experimental orthopaedics. 2019 Dec 1;6(1):29.
  4. Scott CE, Oliver WM, MacDonald D, Wade FA, Moran M, Breusch SJ. Predicting dissatisfaction following total knee arthroplasty in patients under 55 years of age. The bone & joint journal. 2016 Dec;98(12):1625-34.
  5. 5.0 5.1 5.2 5.3 Medscape. Total knee arthroplasty (TKA). Available from: https://emedicine.medscape.com/article/1250275-overview#:~:text=The%20primary%20indication%20for%20total,pain%20caused%20by%20severe%20arthritis. (accessed 28/07/2020).
  6. Maney AJ, Koh CK, Frampton CM, Young SW. Usually, selectively, or rarely resurfacing the patella during primary total knee arthroplasty: determining the best strategy. JBJS. 2019 Mar 6;101(5):412-20.
  7. 7.0 7.1 7.2 Nucleus Medicine Media. Total Knee replacement surgery. Available from: https://www.youtube.com/watch?v=EV6a995pyYk [Accessed 22 December 2020]
  8. Berstock JR, Murray JR, Whitehouse MR, Blom AW, Beswick AD. Medial subvastus versus the medial parapatellar approach for total knee replacement: a systematic review and meta-analysis of randomized controlled trials. EFORT open reviews. 2018 Mar;3(3):78-84.
  9. Parcells BW, Tria AJ. The cruciate ligaments in total knee arthroplasty. American Journal of Orthopaedics (Belle Mead NJ), 45(4), pp. E153-60. 2016;45(4):153-60.
  10. Physiopedia. 2020. Partial Knee Replacement. [online] Available at: <https://physio-pedia.com/Partial_Knee_Replacement?utm_source=physiopedia&utm_medium=search&utm_campaign=ongoing_internal> [Accessed 22 December 2020].
  11. 2020. Guideline - Joint Replacement (Primary): Hip, Knee And Shoulder. [ebook] NATIONAL INSTITUTE FOR HEALTH AND CARE 2 EXCELLENCE, p.5. Available at: <https://www.nice.org.uk/guidance/ng157/documents/draft-guideline> [Accessed 22 December 2020].
  12. Fan Y, Jin J, Sun Z, Li W, Lin J, Weng X, Qiu G. The limited use of a tourniquet during total knee arthroplasty: a randomized controlled trial. Knee. 2014; 21(6): 1263-1268
  13. Panjwani TR, Mullaji A, Doshi K, Thakur H. Comparison of functional outcomes of computer-assisted vs conventional total knee arthroplasty: a systematic review and meta-analysis of high-quality, prospective studies. The Journal of arthroplasty. 2019 Mar 1;34(3):586-93.
  14. Blagojevic, M., Jinks, C., Jeffery, A. and Jordan, K. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis and Cartilage. 2010;18(1):24-33.
  15. Driban J, McAlindon T, Amin M, Price L, Eaton C, Davis J et al. Risk factors can classify individuals who develop accelerated knee osteoarthritis: Data from the osteoarthritis initiative. Journal of Orthopaedic Research. 2017;36(3):876-880.
  16. 16.0 16.1 Fu K, Robbins S, McDougall J. Osteoarthritis: the genesis of pain. Rheumatology. 2017;57(suppl_4):iv43-iv50.
  17. Knee Replacement Surgery By The Numbers - The Center [Internet]. The Center Orthopedic and Neurosurgical Care & Research. 2020 [cited 22 December 2020]. Available from: https://www.thecenteroregon.com/medical-blog/knee-replacement-surgery-by-the-numbers/
  18. 18.0 18.1 Singh J, Yu S, Chen L, Cleveland J. Rates of Total Joint Replacement in the United States: Future Projections to 2020–2040 Using the National Inpatient Sample. The Journal of Rheumatology. 2019;46(9):1134-1140.
  19. Ravi B, Croxford R, Reichmann W, Losina E, Katz J, Hawker G. The changing demographics of total joint arthroplasty recipients in the United States and Ontario from 2001 to 2007. Best Practice & Research Clinical Rheumatology. 2012;26(5):637-647.
  20. 20.0 20.1 Foran J. Total Knee Replacement - OrthoInfo - AAOS [Internet]. Orthoinfo. 2020 [cited 22 December 2020]. Available from: https://orthoinfo.aaos.org/en/treatment/total-knee-replacement/
  21. Huber E, de Bie R, Roos E, Bischoff-Ferrari H. Effect of pre-operative neuromuscular training on functional outcome after total knee replacement: a randomized-controlled trial. BMC Musculoskeletal Disorders. 2013;14(1).
  22. Kwok I, Paton B, Haddad F. Does Pre-Operative Physiotherapy Improve Outcomes in Primary Total Knee Arthroplasty? — A Systematic Review. The Journal of Arthroplasty. 2015;30(9):1657-1663.
  23. Alghadir A, Iqbal Z, Anwer S. Comparison of the effect of pre- and post-operative physical therapy versus post-operative physical therapy alone on pain and recovery of function after total knee arthroplasty. Journal of Physical Therapy Science. 2016;28(10):2754-2758.
  24. Husted R, Juhl C, Troelsen A, Thorborg K, Kallemose T, Rathleff M et al. The relationship between prescribed pre-operative knee-extensor exercise dosage and effect on knee-extensor strength prior to and following total knee arthroplasty: a systematic review and meta-regression analysis of randomized controlled trials. Osteoarthritis and Cartilage. 2020;28(11):1412-1426.
  25. Chesham R, Shanmugam S. Does preoperative physiotherapy improve postoperative, patient-based outcomes in older adults who have undergone total knee arthroplasty? A systematic review. Physiotherapy Theory and Practice. 2016;33(1):9-30.
  26. Henderson K, Wallis J, Snowdon D. Active physiotherapy interventions following total knee arthroplasty in the hospital and inpatient rehabilitation settings: a systematic review and meta-analysis. Physiotherapy. 2018;104(1):25-35.
  27. 27.0 27.1 27.2 McHugh, A, Rehabilitation Guidelines Following Total Knee Arthroplasty. Physioplus. 2021.
  28. Gauthier-Kwan O, Dobransky J, Dervin G. Quality of Recovery, Postdischarge Hospital Utilization, and 2-Year Functional Outcomes After an Outpatient Total Knee Arthroplasty Program. The Journal of Arthroplasty. 2018;33(7):2159-2164.e1.
  29. 29.0 29.1 29.2 29.3 29.4 Artz N, Elvers K, Lowe C, Sackley C, Jepson P, Beswick A. Effectiveness of physiotherapy exercise following total knee replacement: systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2015;16(1).
  30. Jiang Y, Sanchez-Santos M, Judge A, Murray D, Arden N. Predictors of Patient-Reported Pain and Functional Outcomes Over 10 Years After Primary Total Knee Arthroplasty: A Prospective Cohort Study. The Journal of Arthroplasty. 2017;32(1):92-100.e2.
  31. 31.0 31.1 Bourne R. Measuring Tools for Functional Outcomes in Total Knee Arthroplasty. Clinical Orthopaedics and Related Research. 2008;466(11):2634-2638.
  32. Meier W, Mizner R, Marcus R, Dibble L, Peters C, Lastayo P. Total Knee Arthroplasty: Muscle Impairments, Functional Limitations, and Recommended Rehabilitation Approaches. Journal of Orthopaedic & Sports Physical Therapy. 2008;38(5):246-256.
  33. Bech M, Moorhen J, Cho M, Lavergne M, Stothers K, Hoens A. Device or Ice: The Effect of Consistent Cooling Using a Device Compared with Intermittent Cooling Using an Ice Bag after Total Knee Arthroplasty. Physiotherapy Canada. 2015;67(1):48-55.
  34. Adie S, Kwan A, Naylor J, Harris I, Mittal R. Cryotherapy following total knee replacement. Cochrane Database of Systematic Reviews. 2012.
  35. UnityPoint Health - Cedar Rapids. Knee replacement exercise video for UnityPoint Health - St. Luke's Hospital patients [Internet]. 2020 [cited 22 December 2020]. Available from: https://www.youtube.com/watch?v=nM0K5MlQc3U
  36. 36.0 36.1 González Della Valle A, Leali A, Haas S. Etiology and Surgical Interventions for Stiff Total Knee Replacements. HSS Journal. 2007;3(2):182-189.
  37. 37.0 37.1 37.2 Si H, Zeng Y, Zhong J, Zhou Z, Lu Y, Cheng J et al. The effect of primary total knee arthroplasty on the incidence of falls and balance-related functions in patients with osteoarthritis. Scientific Reports. 2017;7(1).
  38. 38.0 38.1 38.2 Moutzouri M, Gleeson N, Billis E, Tsepis E, Panoutsopoulou I, Gliatis J. The effect of total knee arthroplasty on patients’ balance and incidence of falls: a systematic review. Knee Surgery, Sports Traumatology, Arthroscopy. 2016;25(11):3439-3451.
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