Respiratory Disorders: Difference between revisions

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== Introduction ==
== Introduction ==
[[File:Respiratory System basic.png|right|frameless|299x299px]]
[[File:Respiratory Therapist.jpeg|thumb|Respiratory Therapist]]
We take our [[Breathing Pattern Disorders|breathing]] and our [[Respiratory System|respiratory]] health for granted, but the lung is a vital organ that is vulnerable to airborne infection and injury, from the external environment because of its constant exposure to particles, chemicals and infectious organisms in ambient air. Respiratory symptoms are among the major causes of consultation at primary health care centres.<ref name=":1">WHO [https://www.who.int/gard/publications/chronic_respiratory_diseases.pdf Chronic respiratory diseases] Available from:https://www.who.int/gard/publications/chronic_respiratory_diseases.pdf (accessed 7.5.2021)</ref>
Respiratory disease are any of the diseases and disorders of the airways and the [[Lung Anatomy|lungs]] that affect human respiration.<ref>Britannica Respiratory Disorders Available:https://www.britannica.com/science/respiratory-disease (accessed 22.10.2022)</ref> Any part of the [[Respiratory System|respiratory system]] may become [[Infectious Disease|infected]] or diseased and the effects may have a wide variety of complications. The response to infection, as else where in the body, is an [[Inflammation Acute and Chronic|inflammatory]] reaction. As a result hyperaemia and swelling of the mucous lining occur causing difficulty in respiration and a degree of hypoventilation. [[Fibrosis]] occurs if the condition becomes [[Chronic Disease|chronic]], resulting in a loss of elasticity, with possible permanent decrease in ventilation. The [[oxygen]] uptake is impaired and carbon dioxide accumulates. The tissues no longer perform as well and general health is impaired, with the patient easily fatiguing.<ref>Medical Geek  Introduction to diseases of the respiratory system Available:http://www.medicalgeek.com/lecture-notes/8090-introduction-diseases-respiratory-system.html (accessed 22.10.2022)</ref>
 
There are two types of [[:Category:Respiratory Disease|respiratory diseases]] and disorders: [[Communicable Diseases|Infectious]] and [[Chronic Disease|Chronic]].  


Alongside the inflammatory reaction, there is increased mucus secretion, resulting in obstruction of the airways with collapse of the lung tissue distal to the block. It is of paramount importance to regain expansion of the area as soon as possible because the collapsed tissue becomes fibrosed, with permanent reduction of the ventilation capacity of the lungs.
== Types of Respiratory Disorders ==
There are two types of [[:Category:Respiratory Disease|respiratory diseases]] and disorders: [[Communicable Diseases|Infectious]] and [[Chronic Disease|Chronic]].
# Pulmonary infections are most commonly [[Bacterial Infections|bacterial]] or [[Viral Infections|viral]]. In the viral type, a pathogen replicates inside a cell and causes a disease, such as the [[Influenza|flu]].People with weakened [[Lung Anatomy|lungs]] and [[Immunocompromised Client|immune systems]] are more vulnerable to [[Communicable Diseases|infectious]] respiratory conditions
# Pulmonary infections are most commonly [[Bacterial Infections|bacterial]] or [[Viral Infections|viral]]. In the viral type, a pathogen replicates inside a cell and causes a disease, such as the [[Influenza|flu]].People with weakened [[Lung Anatomy|lungs]] and [[Immunocompromised Client|immune systems]] are more vulnerable to [[Communicable Diseases|infectious]] respiratory conditions
# [[Chronic Disease|Chronic]] lung diseases, fall into one of two main classes: Obstructive or Restrictive<ref name=":0">US news Respiratory diseases Available from:https://health.usnews.com/conditions/respiratory-disease (accessed 7.5.2021)</ref><ref>Visible body Respiratory diseases Available from:https://www.visiblebody.com/learn/respiratory/diseases-and-disorders (accessed 7.5.2021)</ref>.
# [[Chronic Disease|Chronic]] lung diseases, fall into one of two main classes: Obstructive or Restrictive<ref name=":0">US news Respiratory diseases Available from:https://health.usnews.com/conditions/respiratory-disease (accessed 7.5.2021)</ref><ref>Visible body Respiratory diseases Available from:https://www.visiblebody.com/learn/respiratory/diseases-and-disorders (accessed 7.5.2021)</ref>.
Global Burden: Respiratory diseases are leading causes of death and disability in the world.[[File:Respiratory diseases world map-DALYs per million persons.png|701x701px|alt=|center|thumb|Age-standardised [[Disability-Adjusted Life Year|DALY]] rates from respiratory diseases by country (per 100,000 inhabitants).]]


== Global Burden ==
== Chronic Respiratory Disorders ==
[[File:Respiratory diseases world map-DALYs per million persons.png|right|frameless|465x465px]]
[[File:Respiratory disorder.jpeg|thumb|350x350px|Respiratory disorder]]
Respiratory diseases are leading causes of death and disability in the world.  
Chronic respiratory diseases (CRDs) are a group of chronic diseases affecting the airways and the other structures of the lungs. Hundreds of millions of people around the world suffer from preventable chronic respiratory diseases.<ref name=":1">WHO [https://www.who.int/gard/publications/chronic_respiratory_diseases.pdf Chronic respiratory diseases] Available from:https://www.who.int/gard/publications/chronic_respiratory_diseases.pdf (accessed 7.5.2021)</ref>See also [[:Category:Chronic Respiratory Disease - Conditions|Category:Chronic Respiratory Disease - Conditions]]


Image: [[Disability-Adjusted Life Year|Disability-adjusted life years]] (DALY) lost from Respiratory diseases in 2012 per million persons. Lightest colour to darkest 4,816-11,210, 11,213-13,190, 13,230-15,471, 15,473-16,342, 16,399-17,477, 17,511-17,511, 17,580-20,920, 21,024-23,320, 24,847-31,538
Alongside tobacco smoke, other risk factors include air pollution, occupational chemicals and dusts, and frequent lower respiratory infections during childhood. CRDs are not curable; however, various forms of treatment that help open the air passages and improve shortness of breath can help control symptoms and improve daily  life for people living with these conditions.<ref>WHO Chronic Respiratory Diseases Available:https://www.who.int/health-topics/chronic-respiratory-diseases#tab=tab_1 (accessed 22.10.2022)</ref>  
 
* About 65 million people suffer from chronic obstructive pulmonary disease (COPD) and 3 million die from it each year, making it the third leading cause of death worldwide.
* About 334 million people suffer from asthma, the most common chronic disease of childhood affecting 14% of all children globally.
* Pneumonia kills millions of people annually and is a leading cause of death among children under 5 years old.
* Over 10 million people develop tuberculosis (TB) and 1.4 million die from it each year, making it the most common lethal infectious disease.
* Lung cancer kills 1.6 million people each year and is the most deadly cancer.
* Globally, 4 million people die prematurely from chronic respiratory disease. At least 2 billion people are exposed to indoor toxic smoke, 1 billion inhale outdoor pollutant air and 1 billion are exposed to [[Smoking and Exercise|tobacco smoke.]]<ref name=":2">FIRS The Global Impact of Respiratory Disease Available from:https://www.who.int/gard/publications/The_Global_Impact_of_Respiratory_Disease.pdf (accessed 7.5.2021)</ref>
 
== Chronic Respiratory Disorders ==
[[File:Pathology.jpg|right|frameless]]
Chronic respiratory diseases are a group of chronic diseases affecting the airways and the other structures of the lungs. Hundreds of millions of people around the world suffer from preventable chronic respiratory diseases.<ref name=":1" />


1.Obstructive Conditions: involve blocked or narrowed airways, making it difficult for the lungs to exhale and exchange old air for fresh air. eg.
'''Obstructive Conditions''': involve blocked or narrowed airways, making it difficult for the lungs to exhale and exchange old air for fresh air. eg.


* [[COPD (Chronic Obstructive Pulmonary Disease)|Chronic obstructive pulmonary disease]] An estimated 65 million people have moderate to severe chronic obstructive pulmonary disease (COPD), from which about 3 million die each year.
#[[COPD (Chronic Obstructive Pulmonary Disease)|Chronic obstructive pulmonary disease]] An estimated 65 million people have moderate to severe chronic obstructive pulmonary disease (COPD), from which about 3 million die each year.
* Alpha-1 antitrypsin deficiency
# Alpha-1 antitrypsin deficiency
* [[File:Normal lungs.jpg|right|frameless|413x413px]][[Asthma]] About 334 million people suffer from asthma [4], which is the most common chronic disease of childhood, affecting 14% of children globally. The prevalence of asthma in children is rising
#[[Asthma]] About 334 million people suffer from asthma [4], which is the most common chronic disease of childhood, affecting 14% of children globally. The prevalence of asthma in children is rising
* [[Bronchiectasis]] ,  
#[[Bronchiectasis]] ,
* [[Cystic Fibrosis|Cystic fibrosis]].
#[[Cystic Fibrosis|Cystic fibrosis]].


2. Restrictive Conditions: reduces the [[Lung Volumes|volume of air that the lungs can hold]]. Lungs can lose their elasticity or the ability to expand.eg
'''Restrictive Conditions''': reduces the [[Lung Volumes|volume of air that the lungs can hold]]. Lungs can lose their elasticity or the ability to expand.eg


* [[Pulmonary Fibrosis|Pulmonary fibrosis]],
#[[Pulmonary Fibrosis|Pulmonary fibrosis]],
* [[Sarcoidosis]],  
#[[Sarcoidosis]],
* [[Lung Cancer|Lung cancer]]<ref name=":0" />The most common lethal [[Oncology|neoplasm]] in the world is lung cancer, which kills 1.6 million people each year ; and the numbers are growing.<ref name=":2" />
#[[Lung Cancer|Lung cancer]]<ref name=":0" />The most common lethal [[Oncology|neoplasm]] in the world is lung cancer, which kills 1.6 million people each year ; and the numbers are growing.<ref name=":2">FIRS The Global Impact of Respiratory Disease Available from:https://www.who.int/gard/publications/The_Global_Impact_of_Respiratory_Disease.pdf (accessed 7.5.2021)</ref>


== Infectious Conditions ==
== Infectious Conditions ==
[[File:Covid19-Test.jpg|right|frameless|alt=]]
[[File:Pneumonia cartoon.jpg|right|frameless]]
Infectious lung conditions are usually temporary, although some respiratory infections can become chronic or frequently recur. For decades, [[:Category:Acute Respiratory Disorders - Conditions|acute lower respiratory tract infections]] have been among the top three causes of death and disability among both children and adults.<ref name=":2" />eg
Infectious lung conditions are usually temporary, although some respiratory infections can become chronic or frequently recur. For decades, [[:Category:Acute Respiratory Disorders - Conditions|acute lower respiratory tract infections]] have been among the top three causes of death and disability among both children and adults.<ref name=":2" /> Pulmonary infections are common and are caused by a wide range of organisms. Causes include:


* [[COVID-19]]. Globally, as of 3:39pm CEST, 6 May 2021, there have been 154,815,600 confirmed cases of COVID-19, including 3,236,104 deaths, reported to WHO. As of 4 May 2021, a total of 1,170,942,729 vaccine doses have been administered<ref>WHO Available:https://covid19.who.int/</ref>.
# Pulmonary [[Viral Infections|viral infection]]
* [[Pneumonia]] is a lung infection most commonly caused by bacteria or viruses. People with chronic respiratory conditions like COPD are more vulnerable to developing pneumonia.
# Pulmonary [[Bacterial Infections|bacterial infection]]: bacterial pneumonia
* [[Tuberculosis]] is a bacterial infection that affects the lungs and other parts of the body. TB can be inactive, or latent, for many years. In 2015, 10.4 million people developed tuberculosis (TB) and 1.4 million people died from it.<ref name=":2" />
# Pulmonary mycobacterial infection: [[Tuberculosis|pulmonary tuberculosis]]; pulmonary nontuberculous mycobacterial infection
# Pulmonary fungal infection: [[Aspergillosis|pulmonary aspergillosis]] <ref>Radiopedia Pulmonary Infection Available:https://radiopaedia.org/articles/pulmonary-infection (accessed 22.10.2022)</ref>


== The Future ==
== The Future ==
Line 66: Line 58:


* Despite progress in understanding the pathological mechanisms involved in each of these disorders, there is still no effective therapy able to halt their natural history or reverse the morphological and functional injury already established. At end-stage lung disease, [[Heart Lung Transplant|lung transplantation]] remains the only feasible intervention.
* Despite progress in understanding the pathological mechanisms involved in each of these disorders, there is still no effective therapy able to halt their natural history or reverse the morphological and functional injury already established. At end-stage lung disease, [[Heart Lung Transplant|lung transplantation]] remains the only feasible intervention.
* The gut–lung axis has emerged as a specific axis with intensive dialogues between the [[Gut Brain Axis (GBA)|gut]] and lungs, involving each compartment in a two-way manner, with both microbial and immune interactions . Each kingdom and compartment plays a crucial role in this dialogue, and consequently in host health and diseases.  The lung microbiota is now recognized as a cornerstone in the physiopathology of numerous respiratory diseases. Their manipulation could pave the way for new approaches in the management of several respiratory diseases such as acute infections, COPD, asthma, and/or CF<ref>Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieërs G, Guery B, Delhaes L. [https://www.frontiersin.org/articles/10.3389/fcimb.2020.00009/full The gut-lung axis in health and respiratory diseases: a place for inter-organ and inter-kingdom crosstalks.] Frontiers in cellular and infection microbiology. 2020 Feb 19;10:9.Available from: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00009/full (accessed 8.5.2021)</ref>.
* The gut–lung axis has emerged as a specific axis with intensive dialogues between the [[Gut Brain Axis (GBA)|gut]] and lungs, involving each compartment in a two-way manner, with both microbial and immune interactions . The lung microbiota is now recognized as a cornerstone in the physiopathology of numerous respiratory diseases<ref>Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieërs G, Guery B, Delhaes L. [https://www.frontiersin.org/articles/10.3389/fcimb.2020.00009/full The gut-lung axis in health and respiratory diseases: a place for inter-organ and inter-kingdom crosstalks.] Frontiers in cellular and infection microbiology. 2020 Feb 19;10:9.Available from: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00009/full (accessed 8.5.2021)</ref>.
* [[Research]] in respiratory diseases is the hope for today and the promise for tomorrow. Research must answer many questions: how do lung diseases arise, how do they are spread, who is vulnerable, and what actions can be used control or cure them, to name a few.<ref name=":2" />
* Research in respiratory diseases is the hope for today and the promise for tomorrow. Research must answer many questions: how do lung diseases arise, how do they are spread, who is vulnerable, and what actions can be used control or cure them, to name a few.<ref name=":2" />


== Physiotherapy ==
== Physiotherapy ==

Latest revision as of 02:59, 22 October 2022


Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton, Simisola Ajeyalemi and Kim Jackson  

Introduction[edit | edit source]

Respiratory Therapist

Respiratory disease are any of the diseases and disorders of the airways and the lungs that affect human respiration.[1] Any part of the respiratory system may become infected or diseased and the effects may have a wide variety of complications. The response to infection, as else where in the body, is an inflammatory reaction. As a result hyperaemia and swelling of the mucous lining occur causing difficulty in respiration and a degree of hypoventilation. Fibrosis occurs if the condition becomes chronic, resulting in a loss of elasticity, with possible permanent decrease in ventilation. The oxygen uptake is impaired and carbon dioxide accumulates. The tissues no longer perform as well and general health is impaired, with the patient easily fatiguing.[2]

Alongside the inflammatory reaction, there is increased mucus secretion, resulting in obstruction of the airways with collapse of the lung tissue distal to the block. It is of paramount importance to regain expansion of the area as soon as possible because the collapsed tissue becomes fibrosed, with permanent reduction of the ventilation capacity of the lungs.

Types of Respiratory Disorders[edit | edit source]

There are two types of respiratory diseases and disorders: Infectious and Chronic.

  1. Pulmonary infections are most commonly bacterial or viral. In the viral type, a pathogen replicates inside a cell and causes a disease, such as the flu.People with weakened lungs and immune systems are more vulnerable to infectious respiratory conditions
  2. Chronic lung diseases, fall into one of two main classes: Obstructive or Restrictive[3][4].

Global Burden: Respiratory diseases are leading causes of death and disability in the world.

Age-standardised DALY rates from respiratory diseases by country (per 100,000 inhabitants).

Chronic Respiratory Disorders[edit | edit source]

Respiratory disorder

Chronic respiratory diseases (CRDs) are a group of chronic diseases affecting the airways and the other structures of the lungs. Hundreds of millions of people around the world suffer from preventable chronic respiratory diseases.[5]See also Category:Chronic Respiratory Disease - Conditions

Alongside tobacco smoke, other risk factors include air pollution, occupational chemicals and dusts, and frequent lower respiratory infections during childhood. CRDs are not curable; however, various forms of treatment that help open the air passages and improve shortness of breath can help control symptoms and improve daily  life for people living with these conditions.[6]

Obstructive Conditions: involve blocked or narrowed airways, making it difficult for the lungs to exhale and exchange old air for fresh air. eg.

  1. Chronic obstructive pulmonary disease An estimated 65 million people have moderate to severe chronic obstructive pulmonary disease (COPD), from which about 3 million die each year.
  2. Alpha-1 antitrypsin deficiency
  3. Asthma About 334 million people suffer from asthma [4], which is the most common chronic disease of childhood, affecting 14% of children globally. The prevalence of asthma in children is rising
  4. Bronchiectasis ,
  5. Cystic fibrosis.

Restrictive Conditions: reduces the volume of air that the lungs can hold. Lungs can lose their elasticity or the ability to expand.eg

  1. Pulmonary fibrosis,
  2. Sarcoidosis,
  3. Lung cancer[3]The most common lethal neoplasm in the world is lung cancer, which kills 1.6 million people each year ; and the numbers are growing.[7]

Infectious Conditions[edit | edit source]

Pneumonia cartoon.jpg

Infectious lung conditions are usually temporary, although some respiratory infections can become chronic or frequently recur. For decades, acute lower respiratory tract infections have been among the top three causes of death and disability among both children and adults.[7] Pulmonary infections are common and are caused by a wide range of organisms. Causes include:

  1. Pulmonary viral infection
  2. Pulmonary bacterial infection: bacterial pneumonia
  3. Pulmonary mycobacterial infection: pulmonary tuberculosis; pulmonary nontuberculous mycobacterial infection
  4. Pulmonary fungal infection: pulmonary aspergillosis [8]

The Future[edit | edit source]

Infection control mask.jpg

Respiratory diseases are an enormous challenge to life, health and productive human activity.

  • Prevention, control and cure of these diseases and promotion of respiratory health must be a top priority in global decision making in the health sector.
  • The control, prevention and cure of respiratory diseases are among the most cost-effective health interventions available.
  • Investment in respiratory health will pay manifold dividends in longevity, healthy living days and national economies.


Respiratory diseases are mostly caused by genetic and environmental factors and/or social behaviors that lead to lung inflammation, injury and remodeling, and progressive deterioration of lung function.

  • Despite progress in understanding the pathological mechanisms involved in each of these disorders, there is still no effective therapy able to halt their natural history or reverse the morphological and functional injury already established. At end-stage lung disease, lung transplantation remains the only feasible intervention.
  • The gut–lung axis has emerged as a specific axis with intensive dialogues between the gut and lungs, involving each compartment in a two-way manner, with both microbial and immune interactions . The lung microbiota is now recognized as a cornerstone in the physiopathology of numerous respiratory diseases[9].
  • Research in respiratory diseases is the hope for today and the promise for tomorrow. Research must answer many questions: how do lung diseases arise, how do they are spread, who is vulnerable, and what actions can be used control or cure them, to name a few.[7]

Physiotherapy[edit | edit source]

See specific disease link and Respiratory Disease - ConditionsRespiratory System - Assessment and Examination‏‎ Respiratory Disease - Interventions

References[edit | edit source]

  1. Britannica Respiratory Disorders Available:https://www.britannica.com/science/respiratory-disease (accessed 22.10.2022)
  2. Medical Geek Introduction to diseases of the respiratory system Available:http://www.medicalgeek.com/lecture-notes/8090-introduction-diseases-respiratory-system.html (accessed 22.10.2022)
  3. 3.0 3.1 US news Respiratory diseases Available from:https://health.usnews.com/conditions/respiratory-disease (accessed 7.5.2021)
  4. Visible body Respiratory diseases Available from:https://www.visiblebody.com/learn/respiratory/diseases-and-disorders (accessed 7.5.2021)
  5. WHO Chronic respiratory diseases Available from:https://www.who.int/gard/publications/chronic_respiratory_diseases.pdf (accessed 7.5.2021)
  6. WHO Chronic Respiratory Diseases Available:https://www.who.int/health-topics/chronic-respiratory-diseases#tab=tab_1 (accessed 22.10.2022)
  7. 7.0 7.1 7.2 FIRS The Global Impact of Respiratory Disease Available from:https://www.who.int/gard/publications/The_Global_Impact_of_Respiratory_Disease.pdf (accessed 7.5.2021)
  8. Radiopedia Pulmonary Infection Available:https://radiopaedia.org/articles/pulmonary-infection (accessed 22.10.2022)
  9. Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieërs G, Guery B, Delhaes L. The gut-lung axis in health and respiratory diseases: a place for inter-organ and inter-kingdom crosstalks. Frontiers in cellular and infection microbiology. 2020 Feb 19;10:9.Available from: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00009/full (accessed 8.5.2021)