Cryotherapy: Difference between revisions

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<div class="editorbox"> '''Original Editor '''- [[User:Francky Petit| Francky Petit]] '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div>
<div class="noeditbox">Welcome to  [[Arkansas Colleges of Health Education School of Physical Therapy Musculoskeletal 1 Project]].  This space was created by and for the students at Arkansas Colleges of Health Education School in the United States. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!</div><div class="editorbox"> '''Original Editor '''- [[User:Francky Petit| Francky Petit]] '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div>
== Definition/Description  ==
== Definition/Description  ==


Cryotherapy, also known as [[Therapeutic Modalities|ice application]], is the simplest and oldest way to treat injuries. Its worldwide use spread because of its effectiveness, convenience, low cost and ease of transportation. Ice is believed to control pain by instigating local anaesthesia. It also decreases oedema, nerve conduction velocities, cellular metabolism and local blood flow. The effect of the cryotherapy depends on the method, the duration, temperature of the ice and the depth of the subcutaneous fat. <ref name="aa">Bleakley C, McDonough S, MacAuley D. [https://www.ncbi.nlm.nih.gov/pubmed/14754753 The use of ice in the treatment of acute soft-tissue injury: a systematic review of randomized controlled trials.] The American journal of sports medicine. 2004 Jan;32(1):251-61.</ref><ref name="ab">Dykstra JH, Hill HM, Miller MG, Cheatham CC, Michael TJ, Baker RJ. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657028/ Comparisons of cubed ice, crushed ice, and wetted ice on intramuscular and surface temperature changes.] Journal of athletic training. 2009 Mar;44(2):136-41.</ref>
Cryotherapy, also known as [[Therapeutic Modalities|ice application]], is the simplest and oldest way to treat injuries. Its worldwide use spread because of its effectiveness, convenience, low cost and ease of transportation. Ice is believed to control pain by instigating local anaesthesia. It also decreases oedema, nerve conduction velocities, cellular metabolism and local blood flow. The effect of the cryotherapy depends on the method, the duration, temperature of the ice and the depth of the subcutaneous fat. <ref name="aa">Bleakley C, McDonough S, MacAuley D. [https://www.ncbi.nlm.nih.gov/pubmed/14754753 The use of ice in the treatment of acute soft-tissue injury: a systematic review of randomized controlled trials.] The American journal of sports medicine. 2004 Jan;32(1):251-61.</ref><ref name="ab">Dykstra JH, Hill HM, Miller MG, Cheatham CC, Michael TJ, Baker RJ. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657028/ Comparisons of cubed ice, crushed ice, and wetted ice on intramuscular and surface temperature changes.] Journal of athletic training. 2009 Mar;44(2):136-41.</ref>


== Lewis Hunting Reaction ==
== Application Methods ==
The Lewis hunting reaction or '''hunting response''' is a process of alternating vasoconstriction and vasodilation in extremities exposed to cold. The term '''Lewis reaction''' is used too, named after Thomas Lewis, who first described the effect in 1930. Vasoconstriction occurs first to reduce heat loss, but also results in strong cooling of the extremities. Approximately five to ten minutes after the start of cold exposure, the blood vessels in the extremities will suddenly vasodilate. This is probably caused by a sudden decrease in the release of neurotransmitters from the sympathetic nerves to the muscular coat of the arteriovenous anastomoses due to local cold. This cold-induced vasodilation increases blood flow and subsequently the temperature of the fingers. A new phase of vasoconstriction follows the vasodilation, after which the process repeats itself.<ref>Daanen HA. [https://pubmed.ncbi.nlm.nih.gov/12712346/ Finger cold-induced vasodilation: a review. European journal of applied physiology.] 2003 Jun 1;89(5):411-26.</ref>
[[File:Cold Pack.jpg|thumb|150x150px|''Application of cold pack'']]
'''Ice Packs:''' It is most common method of cryotherapy. There are different types of ice used in ice packs. The most common types are ice packs made with cubed, crushed and wetted ice. It was discovered that wetted ice is better to lower surface temperature during treatment and maintaining the lower temperature during recovery. It is also more effective in lowering the intramuscular temperature during treatment.
[[File:ColPac.jpg|thumb|150x150px|''ColPac'']]
'''Commercial Cold Packs:''' Commercial cold packs, such as ColPac and Elasto-Gel, are an efficient and commonly used method of cryotherapy. Usually filled with a petroleum distillate gel material, these cold packs are quicker to apply and reach lower temperatures than traditional ice packs.
 
'''Vapocoolant Spray:''' Utilized as a superficial, cooling agent for reduction of muscle guarding and release of myofascial trigger points. (TEXTBOOK)


Vasodilation can be cold induced after initial period of vasoconstriction when cold is maintained for longer than approximately 15 min or when temperature is reduced below 10C.
'''Immersion:''' Simple immersion, such as an ice bath, can be utilized for full concealment of a distal extremity (e.g., foot, ankle, hand, or wrist). Cold whirlpool is a form of immersion that transfers heat via convection
[[File:Ice Massage.jpg|thumb|154x154px|''Application of ice massage'']]
'''Ice Massage:''' Ice massage involves applying ice directly to the skin with slow strokes in circular motion for 5-10 mins. To achieve desired cooling effect, move the ice about 5-7cm/second. (TEXTBOOK)


== Application Methods  ==
'''[[Whole-body cryotherapy|Whole Body Cryotherapy]]:''' More recently whole-body cryotherapy has become popular for athletes, to help aid recovery, as well as in persistent pain patients such as rheumatological conditions. More research is needed to understand the effect on the body and its relation to pain.
[[File:Ice-pack-calf180.jpg|thumb|Ice pack being used for calf strain]]
# '''Ice Packs''' ''':''' It is most common method of cryotherapy. There are different types of ice used in ice packs. The most common types are ice packs made with cubed, crushed and wetted ice.<ref name="ab" /> It was discovered that wetted ice is better to lower surface temperature during treatment and maintaining the lower temperature during recovery. It is also more effective in lowering the intramuscular temperature during treatment.<ref name="ab" />
# '''Ice Spray :''' A cooling effect can also be produced by icing spray for a similar effect.<ref name=":1">Galiuto L. [https://www.jscimedcentral.com/SportsMedicine/sportsmedicine-3-1060.pdf The use of cryotherapy in acute sports injuries.] Annals of Sports Medicine and Research. 2016;3(2):1060.</ref>
# '''Immersion :''' Simple or whirlpool immersion.
# '''Ice Massage :''' slow strokes in circular motion for 5-10 mins.
More recently whole body cryotherapy has become popular for athletes, to help aid recover, as well as in persistent pain patients such as rheumatological conditions. More research is needed to understand the effect on the body and its relation to pain.<ref>Banfi G, Lombardi G, Colombini A, Melegati G. [https://link.springer.com/article/10.2165/11531940-000000000-00000 Whole-body cryotherapy in athletes]. Sports medicine. 2010 Jun 1;40(6):509-17.</ref>
{{#ev:youtube | gJOMV2mZ1B0}}<ref>George Eliot Hospital. Applying an Icepack - Physiotherapy Advice Video Available from: https://www.youtube.com/watch?v=gJOMV2mZ1B0 [last accessed 28/09/2020] </ref>


{{#ev:youtube | gJOMV2mZ1B0}}<ref>George Eliot Hospital. Applying an Icepack - Physiotherapy Advice Video Available from: https://www.youtube.com/watch?v=gJOMV2mZ1B0 [last accessed 28/09/2020] </ref>


== Indications ==
Cryotherapy can be utilized as an adjunct to treatment for the following conditions: (Therapeutic Modalities TEXTBOOK)


== Conditions treated ==
* Acute soft tissue injuries (e.g., [[Ankle Sprain|ankle sprain]], muscular strain, ligament sprain)
* Acute soft tissue injuries e.g. [[Ankle Sprain|ankle sprain]], muscular sprain, ligament sprain
* Myofascial trigger points
* Myofascial trigger points
* Muscle spasm
* Muscle guarding
* [[Triceps tendonitis|Tendinitis]]
* [[Triceps tendonitis|Tendinitis]]
* Tenosynovitis
* Acute swelling
* Acute swelling
* [[Bursitis]]
* [[Bursitis]]
* Post orthopaedic surgery e.g. [[Total knee arthroplasty|TKR,]] [[ACL Reconstruction|ACL reconstruction]], arthroscopic shoulder surgery.<ref>Ni SH, Jiang WT, Guo L, Jin YH, Jiang TL, Zhao Y, Zhao J. [https://link.springer.com/article/10.1007/s00167-014-3135-x Cryotherapy on postoperative rehabilitation of joint arthroplasty.] Knee Surgery, Sports Traumatology, Arthroscopy. 2015 Nov 1;23(11):3354-61.</ref>
* Post orthopaedic surgery (e.g., [[Total knee arthroplasty|TKR,]] [[ACL Reconstruction|ACL reconstruction]], arthroscopic shoulder surgery.)
* Acute sports injuries
* Reducing temperature
* [[Delayed onset muscle soreness (DOMS)|DOMS]]<ref name=":1" />
* [[Delayed onset muscle soreness (DOMS)|DOMS]]
 
== Contraindications ==
Be aware of conditions in which cryotherapy is contraindicated:
 
* CRPS
* Haemoglobinuria
* Cryoglobulinemia
* [[Peripheral Arterial Disease|Peripheral vascular disease]]
* Impaired circulation
* [[Mixed Connective Tissue Disease|Raynaud’s disease]]
* Urticaria
* Hypersensitivity to cold
* Skin anaesthesia
* Over a regenerating peripheral nerve
* Open wounds
 
== Precautions ==
When applying cryotherapy, be cognizant of the following:
 
* Over a superficial nerve
* Hypertension
* Impaired cognition
* Patients who are very young or very old
 
== Expected Sensations to Cryotherapy ==
Prior to the application of cryotherapy, it is important to understand the expected sensations that one might expect. While the sensations listed may be uncomfortable, they are both normal and necessary to achieve the desired effects from cryotherapy. Throughout the duration of treatment, the expected sensations begin with a cold feeling and should reach numbness by the end.
[[File:Expected Sensations of Cryotherapy.png|center|thumb|500x500px]]
 
== Physiological Effects of Cryotherapy (Therapeutic Modalities TEXTBOOK) ==
 
* Decreased local temperature
* Decreased metabolism
* Vasoconstriction of arterioles and capillaries, initially
* Decreased blood flow, initially
* Decreased nerve conduction velocity
* Decreased delivery of leukocytes and phagocytes
* Decreased lymphatic and venous drainage
* Decreased muscle excitability
* Decreased muscle spindle depolarization
* Decreased formation and accumulation of edema
* Extreme anesthetic effects
 
== Lewis Hunting Reaction ==
The Lewis hunting reaction is a process of alternating vasoconstriction and vasodilation in extremities exposed to cold. The term Lewis reaction is used too, named after Thomas Lewis, who first described the effect in 1930. Vasoconstriction occurs first to reduce heat loss, but also results in strong cooling of the extremities. Approximately five to ten minutes after the start of cold exposure, the blood vessels in the extremities will suddenly vasodilate. This is probably caused by a sudden decrease in the release of neurotransmitters from the sympathetic nerves to the muscular coat of the arteriovenous anastomoses due to local cold. This cold-induced vasodilation increases blood flow and subsequently the temperature of the fingers. A new phase of vasoconstriction follows the vasodilation, after which the process repeats itself.<ref>Daanen HA. [https://pubmed.ncbi.nlm.nih.gov/12712346/ Finger cold-induced vasodilation: a review. European journal of applied physiology.] 2003 Jun 1;89(5):411-26.</ref>
 
Vasodilation can be cold induced after initial period of vasoconstriction when cold is maintained for longer than approximately 15 min or when temperature is reduced below 10C.


==Pros==
==Pros==
Line 39: Line 90:
* Little evidence regarding duration and frequency of treatment to be effective<ref name=":0" />
* Little evidence regarding duration and frequency of treatment to be effective<ref name=":0" />
* Compression has been shown to be more effective post operatively<ref name=":0" />
* Compression has been shown to be more effective post operatively<ref name=":0" />
* In rare cases bradycardia and frostbite symptoms have been observed. <ref name=":1" />
* In rare cases bradycardia and frostbite symptoms have been observed. <ref name=":1">Galiuto L. [https://www.jscimedcentral.com/SportsMedicine/sportsmedicine-3-1060.pdf The use of cryotherapy in acute sports injuries.] Annals of Sports Medicine and Research. 2016;3(2):1060.</ref>
* Some more advanced cryotherapy devices can reduce range of movement following TKR due to immobilisation of the joint. <ref>Thienpont E. [https://link.springer.com/article/10.1007/s11999-014-3810-8 Does advanced cryotherapy reduce pain and narcotic consumption after knee arthroplasty?]. Clinical Orthopaedics and Related Research®. 2014 Nov 1;472(11):3417-23.</ref>
* Some more advanced cryotherapy devices can reduce range of movement following TKR due to immobilisation of the joint. <ref>Thienpont E. [https://link.springer.com/article/10.1007/s11999-014-3810-8 Does advanced cryotherapy reduce pain and narcotic consumption after knee arthroplasty?]. Clinical Orthopaedics and Related Research®. 2014 Nov 1;472(11):3417-23.</ref>
==Possible Risks/Undesirable Effects==
==Possible Risks/Undesirable Effects==


=== Inhibit Muscle Function ===
* Inhibit Muscle Function
* Ice Burn
* Cryotherapy-induced nerve injuries
* Generalized cooling and decrease in core temperature
* Reduced range of motion
 
==== Inhibit Muscle Function ====
*Cooling can temporarily [[Cryotherapy Guidelines|Inhibit muscle function]] with potential for increased risk of injury/re‐injury
*Cooling can temporarily [[Cryotherapy Guidelines|Inhibit muscle function]] with potential for increased risk of injury/re‐injury
*Be cautious when having patients weight bear/undertake complex exercise after icing a lower extremity
*Be cautious when having patients weight bear/undertake complex exercise after icing a lower extremity


=== Ice Burn ===
==== Ice Burn ====
Elderly patients with impaired sensation and/or circulation will be more vulnerable to an ice‐burn, therefore consider using less intense icing techniques (e.g., moderately cold ice pack wrapped in an insulating layer(s) of towel/cloth)
Elderly patients with impaired sensation and/or circulation will be more vulnerable to an ice‐burn, therefore consider using less intense icing techniques (e.g., moderately cold ice pack wrapped in an insulating layer(s) of towel/cloth)
*Younger patients with intact sensation and circulation may benefit most from direct immersion of the limb in cold water then progressively adding ice cubes
*Younger patients with intact sensation and circulation may benefit most from direct immersion of the limb in cold water then progressively adding ice cubes
*Cold gel packs stored in a freezer have a surface temperature below 0°C (32°F) and thus an insulating layer should be used between the cold pack and the patient’s skin
*Cold gel packs stored in a freezer have a surface temperature below 0°C (32°F) and thus an insulating layer should be used between the cold pack and the patient’s skin


=== Cryotherapy‐Induced Nerve Injuries ===
==== Cryotherapy‐Induced Nerve Injuries ====
*Most common when cold is applied in combination with compression
*Most common when cold is applied in combination with compression
*Check capillary refill during application of ice combined with compression therapy to ensure adequate blood flow
*Check capillary refill during application of ice combined with compression therapy to ensure adequate blood flow


=== Generalized Cooling and Decrease in Core Temperature ===
==== Generalized Cooling and Decrease in Core Temperature ====
*Shivering and piloerection are signs of decrease in core temperature which may compromise patient safety (especially in the elderly and those with fever)
*Shivering and piloerection are signs of decrease in core temperature which may compromise patient safety (especially in the elderly and those with fever)
*The application of therapeutic cryotherapy should produce only local effects
*The application of therapeutic cryotherapy should produce only local effects


=== Reduced ROM ===
==== Reduced ROM ====
Ice may contribute to shortening of collagen fibres in connective tissue
Ice may contribute to shortening of collagen fibres in connective tissue
*After gaining ROM by warming, stretching and then strengthening in the newest part of the ROM, it is likely counterproductive to cool the tissue in a shortened position
*After gaining ROM by warming, stretching and then strengthening in the newest part of the ROM, it is likely counterproductive to cool the tissue in a shortened position
*If one wishes to cool the tissue post stretch and exercise, it is best to do so with the tissue in a lengthened position
*If one wishes to cool the tissue post stretch and exercise, it is best to do so with the tissue in a lengthened position
*In patients with significantly restricted ROM due to scar tissue, it may be preferable not to use ice.
*In patients with significantly restricted ROM due to scar tissue, it may be preferable not to use ice.
=== Contraindications ===
Be aware of conditions in which icing is contraindicated<ref>Prohaska J, Badri T. [https://www.ncbi.nlm.nih.gov/books/NBK482319/#:~:text=Other%20contraindications%20for%20cryosurgery%20are,site%20or%20in%20that%20limb. Cryotherapy]. InStatPearls [Internet] 2020 Feb 7. StatPearls Publishing.</ref>
# CRPS, haemoglobinuria, cryoglobulinemia,
# [[Peripheral Arterial Disease|Peripheral vascular disease]]
# Impaired circulation: [[Mixed Connective Tissue Disease|Raynaud’s disease]]
# Urticaria
# Hypersensitivity to cold
# Skin anaesthesia


== Resources    ==
== Resources    ==

Revision as of 20:37, 31 March 2023

Welcome to Arkansas Colleges of Health Education School of Physical Therapy Musculoskeletal 1 Project. This space was created by and for the students at Arkansas Colleges of Health Education School in the United States. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!

Definition/Description[edit | edit source]

Cryotherapy, also known as ice application, is the simplest and oldest way to treat injuries. Its worldwide use spread because of its effectiveness, convenience, low cost and ease of transportation. Ice is believed to control pain by instigating local anaesthesia. It also decreases oedema, nerve conduction velocities, cellular metabolism and local blood flow. The effect of the cryotherapy depends on the method, the duration, temperature of the ice and the depth of the subcutaneous fat. [1][2]

Application Methods[edit | edit source]

Application of cold pack

Ice Packs: It is most common method of cryotherapy. There are different types of ice used in ice packs. The most common types are ice packs made with cubed, crushed and wetted ice. It was discovered that wetted ice is better to lower surface temperature during treatment and maintaining the lower temperature during recovery. It is also more effective in lowering the intramuscular temperature during treatment.

ColPac

Commercial Cold Packs: Commercial cold packs, such as ColPac and Elasto-Gel, are an efficient and commonly used method of cryotherapy. Usually filled with a petroleum distillate gel material, these cold packs are quicker to apply and reach lower temperatures than traditional ice packs.

Vapocoolant Spray: Utilized as a superficial, cooling agent for reduction of muscle guarding and release of myofascial trigger points. (TEXTBOOK)

Immersion: Simple immersion, such as an ice bath, can be utilized for full concealment of a distal extremity (e.g., foot, ankle, hand, or wrist). Cold whirlpool is a form of immersion that transfers heat via convection

Application of ice massage

Ice Massage: Ice massage involves applying ice directly to the skin with slow strokes in circular motion for 5-10 mins. To achieve desired cooling effect, move the ice about 5-7cm/second. (TEXTBOOK)

Whole Body Cryotherapy: More recently whole-body cryotherapy has become popular for athletes, to help aid recovery, as well as in persistent pain patients such as rheumatological conditions. More research is needed to understand the effect on the body and its relation to pain.

[3]

Indications[edit | edit source]

Cryotherapy can be utilized as an adjunct to treatment for the following conditions: (Therapeutic Modalities TEXTBOOK)

  • Acute soft tissue injuries (e.g., ankle sprain, muscular strain, ligament sprain)
  • Myofascial trigger points
  • Muscle spasm
  • Muscle guarding
  • Tendinitis
  • Tenosynovitis
  • Acute swelling
  • Bursitis
  • Post orthopaedic surgery (e.g., TKR, ACL reconstruction, arthroscopic shoulder surgery.)
  • Reducing temperature
  • DOMS

Contraindications[edit | edit source]

Be aware of conditions in which cryotherapy is contraindicated:

Precautions[edit | edit source]

When applying cryotherapy, be cognizant of the following:

  • Over a superficial nerve
  • Hypertension
  • Impaired cognition
  • Patients who are very young or very old

Expected Sensations to Cryotherapy[edit | edit source]

Prior to the application of cryotherapy, it is important to understand the expected sensations that one might expect. While the sensations listed may be uncomfortable, they are both normal and necessary to achieve the desired effects from cryotherapy. Throughout the duration of treatment, the expected sensations begin with a cold feeling and should reach numbness by the end.

Expected Sensations of Cryotherapy.png

Physiological Effects of Cryotherapy (Therapeutic Modalities TEXTBOOK)[edit | edit source]

  • Decreased local temperature
  • Decreased metabolism
  • Vasoconstriction of arterioles and capillaries, initially
  • Decreased blood flow, initially
  • Decreased nerve conduction velocity
  • Decreased delivery of leukocytes and phagocytes
  • Decreased lymphatic and venous drainage
  • Decreased muscle excitability
  • Decreased muscle spindle depolarization
  • Decreased formation and accumulation of edema
  • Extreme anesthetic effects

Lewis Hunting Reaction[edit | edit source]

The Lewis hunting reaction is a process of alternating vasoconstriction and vasodilation in extremities exposed to cold. The term Lewis reaction is used too, named after Thomas Lewis, who first described the effect in 1930. Vasoconstriction occurs first to reduce heat loss, but also results in strong cooling of the extremities. Approximately five to ten minutes after the start of cold exposure, the blood vessels in the extremities will suddenly vasodilate. This is probably caused by a sudden decrease in the release of neurotransmitters from the sympathetic nerves to the muscular coat of the arteriovenous anastomoses due to local cold. This cold-induced vasodilation increases blood flow and subsequently the temperature of the fingers. A new phase of vasoconstriction follows the vasodilation, after which the process repeats itself.[4]

Vasodilation can be cold induced after initial period of vasoconstriction when cold is maintained for longer than approximately 15 min or when temperature is reduced below 10C.

Pros[edit | edit source]

  • Pain relief[5]
  • Swelling reduction[5]
  • Decreased surface temperature
  • Effective on a wide range of soft tissue injuries

Cons[edit | edit source]

  • Little evidence regarding duration and frequency of treatment to be effective[5]
  • Compression has been shown to be more effective post operatively[5]
  • In rare cases bradycardia and frostbite symptoms have been observed. [6]
  • Some more advanced cryotherapy devices can reduce range of movement following TKR due to immobilisation of the joint. [7]

Possible Risks/Undesirable Effects[edit | edit source]

  • Inhibit Muscle Function
  • Ice Burn
  • Cryotherapy-induced nerve injuries
  • Generalized cooling and decrease in core temperature
  • Reduced range of motion

Inhibit Muscle Function[edit | edit source]

  • Cooling can temporarily Inhibit muscle function with potential for increased risk of injury/re‐injury
  • Be cautious when having patients weight bear/undertake complex exercise after icing a lower extremity

Ice Burn[edit | edit source]

Elderly patients with impaired sensation and/or circulation will be more vulnerable to an ice‐burn, therefore consider using less intense icing techniques (e.g., moderately cold ice pack wrapped in an insulating layer(s) of towel/cloth)

  • Younger patients with intact sensation and circulation may benefit most from direct immersion of the limb in cold water then progressively adding ice cubes
  • Cold gel packs stored in a freezer have a surface temperature below 0°C (32°F) and thus an insulating layer should be used between the cold pack and the patient’s skin

Cryotherapy‐Induced Nerve Injuries[edit | edit source]

  • Most common when cold is applied in combination with compression
  • Check capillary refill during application of ice combined with compression therapy to ensure adequate blood flow

Generalized Cooling and Decrease in Core Temperature[edit | edit source]

  • Shivering and piloerection are signs of decrease in core temperature which may compromise patient safety (especially in the elderly and those with fever)
  • The application of therapeutic cryotherapy should produce only local effects

Reduced ROM[edit | edit source]

Ice may contribute to shortening of collagen fibres in connective tissue

  • After gaining ROM by warming, stretching and then strengthening in the newest part of the ROM, it is likely counterproductive to cool the tissue in a shortened position
  • If one wishes to cool the tissue post stretch and exercise, it is best to do so with the tissue in a lengthened position
  • In patients with significantly restricted ROM due to scar tissue, it may be preferable not to use ice.

Resources[edit | edit source]

  1. Bleakley C, McDonough S, MacAuley D. The use of ice in the treatment of acute soft-tissue injury: a systematic review of randomized controlled trials. The American journal of sports medicine. 2004 Jan;32(1):251-61.
  2. Dykstra JH, Hill HM, Miller MG, Cheatham CC, Michael TJ, Baker RJ. Comparisons of cubed ice, crushed ice, and wetted ice on intramuscular and surface temperature changes. Journal of athletic training. 2009 Mar;44(2):136-41.
  3. George Eliot Hospital. Applying an Icepack - Physiotherapy Advice Video Available from: https://www.youtube.com/watch?v=gJOMV2mZ1B0 [last accessed 28/09/2020]
  4. Daanen HA. Finger cold-induced vasodilation: a review. European journal of applied physiology. 2003 Jun 1;89(5):411-26.
  5. 5.0 5.1 5.2 5.3 Hubbard TJ, Denegar CR. Does cryotherapy improve outcomes with soft tissue injury?. Journal of athletic training. 2004 Jul;39(3):278.
  6. Galiuto L. The use of cryotherapy in acute sports injuries. Annals of Sports Medicine and Research. 2016;3(2):1060.
  7. Thienpont E. Does advanced cryotherapy reduce pain and narcotic consumption after knee arthroplasty?. Clinical Orthopaedics and Related Research®. 2014 Nov 1;472(11):3417-23.