Original Editor - Kenny Bosmans
Avascular necrosis (also known as osteonecrosis, bone infarction, aseptic necrosis, ischemic bone necrosis and AVN) is a condition where bone tissue dies due to a lack of blood supply. This decrease in blood supply causes a decrease in oxygen and nutrient delivery to the bone, which leads to multiple breaks in the bone and eventual collapse of the affected bone. This condition is most common in younger patients who are between the age of 20 and 40.
Clinical relevant anatomy
The proximal area of the femur forms the hip joint with the pelvis. It consists of a head, neck and two bony processes called trochanters. There are also two bony ridges connecting the two trochanters.
• Head: Articulates with the acetabulum of the pelvis to form the hip joint. It has a smooth surface with a depression on the medial aspect for the attachment of the ligament.
• Neck: Connects the head of the femur with the shaft of the femur. It is cylindrical, projecting in a superior and medial direction. This angle of projection allows for an increased range of motion at the hip joint.
• Trochanter Major: A projection of bone that originates from the anterior aspect, just lateral to the neck. It is angled superior and posterior. A place of attachment for different muscles in the gluteal region, such as M. gluteus medius, M. gluteus minimus and M. piriformis.
Avascular necrosis can be a result of an earlier bone trauma (such as a break in the bone) or a dislocation.
Non-traumatic Osteonecrosis can have many causes:
- heavy drinking  and steroid abuse have been identified as major risk factors
- Numerous studies have also concluded that hyperlipidemia in the femoral head, induced by steroid and alcohol use, are associated with osteonecrosis. Both of these factors precipitate an increase in fat volume in bone marrow and blood lipid levels, thereby increasing deposition of fat and interrupting blood flow to the femoral head.
- Glucocorticoid intake was found to have an even stronger association than alcohol use.
- Cigarette smoking: due to changes in nitric oxide bioavailability, there is an increased oxidative stress level and endothelial dysfunction
- Obesity: osteonecrosis is positively associated with BMI. Overweight and obesity are, just like steroid and alcohol use, often associated with hyperlipidemia.
- A medical condition, such as sickle cell anemia or Systemic Lupus Erythematosus.
Studies show that there is a higher prevalence among males, this could be attributed to higher levels of smoking and alcohol use. Greater fluctuations in climate temperatures may also contribute to higher rates of non-traumatic osteonecrosis. (level 1a) 
Symptoms include pain and decreased range of motion in the affected joint. In some cases, the condition is diagnosed during routine x-ray imaging, due to a lack of overt symptoms. The most common location for this condition to manifest, is the head or neck of the femur or humerus, and the knee joint.
In the beginning, this disease is asymptomatic. It is also plausible there is a segmental collapse present and the patient doesn’t feel it. As the disease progresses, the hip can become stiffer, which is visible in the gait of the patient when he starts to limp. Pain is also observed by support on the leg, in the buttock, groin and thigh.
Avascular necrosis can be classified into five different stages:
- Stage 1: Radiographic changes are absent or show minor osteopaenia. An MRI scan is required for identification (can show oedema). The onset of this disease is asymptomatic.
- Stage 2: First stage with radiographic changes. This stage is characterized by sclerosis of the superior central portion of the joint head and/or osteopenia and/or subchondral cysts.
- Stage 3: In this stage, the articular surface is depressed so that the round contour is compromised, without being significantly deformed. This leads to a joint space narrowing. Plain radiograph shows a crescent sign.
- Stage 4: This stage is characterized by a wide collapse of the subchondral bone and destruction of the underlying trabecular pattern. This can lead to secondary arthritis.
- Stage 5: The final stage where both articular surfaces are affected, which leads to a dysfunctional joint.
For example, if a case presents itself where the patient has has osteonecrosis of the femoral head. Avascular necrosis most commonly affects the hip in more than 72% of the cases. The patient will have mild chronic pain in the hip, the groin, around the buttocks and at the antero-medial thigh, with normal radiograph, they should undergo observation for ONFH and a Hip joints MRI. This pain is most commonly aggravated by activity and internal rotation in flexion. As the disease progresses, the pain may also become present at rest. Without treatment 85% will progress to the collapse of the articular surface and will eventually require total hip arthroplasty.  (level 1a)
Osteonecrosis can be diagnosed with a thorough check of the historical background of the patient combined with physical examination. Steroid exposure and alcohol abuse are important risk factors. The age of the patient can also provide clues to the disease, because patients with osteonecrosis are generally younger than those with osteoarthritis. Locking, popping, or a painful click during mobilization of the affected joint can point to the presence of loose osteochondral fragments. In further stages of the disease, loss of mobilization and increased pain can be detected. Once osteonecrosis is detected, the physician should assess other joints that may be at risk, such as the hip, shoulder and knee.
In the early stages, this condition is asymptomatic, which makes diagnosis almost impossible. However early screening with MRI is currently the best modality for diagnosis due to its sensitivity. The double line sign is an MRI finding seen at the periphery of a region of osteonecrosis. It consists of an inner bright line representing granulation tissue and an outer dark line representing sclerotic bone. Measurement of the size and location of the necrotic lesion is a crucial prognostic parameter to predict collapse and can be better defined on an MRI.  (level 5)
At a more advanced stage, standard radiographs can confirm the diagnose. Tissue affected by avascular necrosis will appear more dense (increased whiteness) and possibly sclerotic (patchy) on the radiograph. An MRI can assist in making the diagnosis. It can show a subchondral radiolucency called a “crescent sign”, it indicates imminent articular collapse.
Choice of outcome measure will be dependent on the joint affected. If the patient reports symptoms of pain, consider a pain rating scale such as the 4-Item Pain Intensity Measure (P4), Numeric Pain Rating Scale, or Visual Analogue Scale.
The Harris Hip Score was developed for the assessment of results after hip surgery and is intended to evaluate various hip disabilities and methods of treatment. (level 1a) 
The HHS is composed of 4 sub-scales: Pain, function, absence of deformity and range of motion. (level 5) 
- The pain domain: measures pain severity, its effect on activities and the need for pain medication.
- The function domain: consists of daily activities (stair use, using public transportation, sitting, and managing shoes and socks) and gait (limp, support needed, and walking distance).
- Deformity: takes into account hip flexion, adduction, internal rotation, and extremity length discrepancy.
- Range of motion: measures hip flexion, abduction, external and internal rotation, and adduction.
The degree of hip pain can also be evaluated by a visual analogue scale (VAS) score (quantifying the number of points on the VAS scale)
The HOOS assesses the patients’ opinion about their hip and other associated problems. People that suffer from hip disability with or without osteoarthritis can use this scale.
It consists of 5 subscales:
- Other symptoms
- Function in activities of daily living (ADL)
- Function in sport and recreation
- Hip- related quality of life (QOL)
A functional outcome measure is useful for establishing the patient's baseline function and setting measurable goals. See Outcome Measures Database for more.
- Pharmacological Therapy
Pharmacological therapy with anticoagulants, statins, and vasodilators seems to be effective to delay the progress of joint degeneration in early stages of avascular necrosis. Although, there is very low evidence to support the use of these pharmacological agents in the treatment of osteonecrosis. Another still experimental treatment are Bisphosphonates. Hypothetically in early stages of AVN the use of bisphosphonates could inhibit osteoclastic activity preventing subchondral bone collapse. (level 2a) 
- Surgical Treatment
Core decompression (for stages 1 and 2 of the disease) creates a tract for example in the femoral head that decompress the head. Hereby facilitating increased blood flow, which will then promote neo-vascularization that could possibly stimulate new bone growth. With the
advent of microsurgery, this surgery can also be done with a bone graft. After you debride the necrotic array, you substitute the necrotic bone with a viable bone (most of the time 15 centimeters of the fibula with the peroneal artery connected to the ascending branch of the
lateral femoral circumflex artery and vein) and to initiate callus formation inside the femoral head. (level 1a)
Osteotomy is a surgical operation whereby a bone is cut to shorten or lengthen it or to change its alignment to decrease the load from the necrotic bone either by rotation of the femoral head and neck or by a varus or valgus angulation of the proximal femur. This treatment is only for young patients without co-morbidities interfering with bone healing. In the United States, angular osteotomy for stage II or III disease at time of intervention has had limited success ranging from 70% to 90% at a follow up from 3 to 18 years.  (level 1a)
When all other things fail, a total hip arthroplasty (commonly in stages 3 and 4) is the only option. In this total hip replacement the damaged bone and cartilage is removed and replaced with prosthetic components.
• The damaged femoral head is removed and replaced with a metal stem that is placed into the hollow center of the femur.
• A metal or ceramic ball is placed on the upper part of the stem (replaces the femoral head)
• The damaged cartilage surface of the socket (acetabulum) is removed and replaced with a metal socket.
• A plastic, ceramic, or metal spacer is inserted between the new ball and the socket to allow for a smooth gliding surface.
Studies show that total hip arthroplasty (32-mm alumina-on-alumina ) in patients with avascular necrosis of the femoral head after a 2 to 10 year follow-up, show good result for long-lasting replacements. It shows a better Harris hip score and pain relief after surgery.  (level 2a)
Physical Therapy Management
Appropriate treatment for avascular necrosis is necessary to prevent further deterioration of the joint. If untreated, most patients will experience severe pain and limitation of movement within two years. Although physical therapy cannot cure avascular necrosis, it can slow down the progression of the disease and decrease associated pain. It is suggested that patients with Stage 1 and 2 osteonecrosis could benefit from a physical therapy program. Most patients will eventually need surgical treatment, such as core decompression or arthroplasty.
Nonoperative treatment involves three main goals:
- Relief of symptoms
- Prevention of disease progression
- Improvement of functionality
Nonoperative treatment begins with patient education and addressing known risk factors, such as smoking and alcohol abuse. In addition, corticosteroids should be avoided.
To assist the patient in regaining function and relieve painful symptoms, crutches or other gait aids can be introduced. The physical therapist should instruct the patient in how to properly use these devices.
By using crutches, the load that the hip joint bears, will be decreased. This weight bearing restriction is an important conservative treatment. In literature, it is considered that weight bearing restriction as a stand-alone therapy is insufficient in preventing disease progression, but it’s a reasonable treatment option when combined with pharmacological agents or surgery. (level 2a) 
Physical therapy treatment focuses on exercises to maintain joint mobility and strengthen the muscles around the affected joint. During physical therapy, excessive compressive and shear forces on the joint should be avoided. The outcome depends on the lesion’s size and stage at the initiation of the treatment.
In order to maintain joint mobility, both passive and active exercises should be initiated. Passive exercises contain passive movements of the hip and stretching exercises. Active exercises consist of 3dimensional motions of the hip joint and can be applied during standing, sitting on a chair or while lying down. In the next stage, strengthening exercises are added. These exercises will focus on the muscles of the hip and thigh but will also include exercises for the core area as they play a large supporting role. To improve functionality it is important to implement endurance training and coordination training in a more advanced stage of the therapy. Endurance can be trained by walking on a treadmill or cycling on a home trainer. To improve coordination, walking exercises with increased complexity and balancing exercises can be adopted in physical therapy sessions. (level 1b) 
Physical therapy after surgery is also a key component for recovery. It starts immediately the day after surgery. They prepare the patients for discharge by showing them how to do their everyday activities like getting in and out of bed and walking with a walker or crutches. (level 5)
In a more advanced stage of the therapy, the therapist instructs the patient on exercises to strengthen their muscles, improve range of motion, work on balance and gait speed. The patient specifically learns how to move, while maintaining hip precautions. The rehabilitation protocol is combined with a home exercise program. Below is an example of a training program in an advanced phase of recovery  (level 5)
Electrical stimulation and ultrasound can be used to stimulate bone growth. For example, Extracorporeal Shock Wave Therapy (ESWT) causes expression of angiogenic growth factors that act as a stimulus to neovascularization and could therefore be useful in the treatment of AVN. The current evidence suggests that ESWT improves pain and function in early stages of disease. Although, more evidence is needed. Heat is also applied as an attempt to increase bloody supply to the area and help decrease pain. It is important not to consider these types of therapy as a stand-alone-therapy, but it can be useful in combination with exercise therapy.  (level 2a)
Gruson K, Kwon Y. Atraumatic osteonecrosis of the humeral head. Bulletin of the NYU Hospital for Joint Diseases 2009;67(1):6-14.
Lee MS, Hsieh PH, Shih CH, Wang CJ. Non-traumatic osteonecrosis of the femoral head – from clinical to bench. Chang Gung Med J 2010;33(4).
Huijbregts P. Osteonecrosis of the humeral head: a literature review and two case studies. J Man Manip Ther 2000;8(4):175-182.
Hasan S, Romeo A, Nontraumatic osteonecrosis of the humeral head. J Shoulder Elbow Surg 2002.
Recent Related Research (from Pubmed)
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- Gruson K, Kwon Y. Atraumatic osteonecrosis of the humeral head. Bulletin of the NYU Hospital for Joint Diseases 2009;67(1):6-14.
- De-Wei Zhao et al. “Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey” (2015): 2843-2850 (level 1a)
- Lee MS, Hsieh PH, Shih CH, Wang CJ. Non-traumatic osteonecrosis of the femoral head – from clinical to bench. Chang Gung Med J 2010;33(4).
- Bentley, George. 2012. European Instructional. Lectures13th EFORT Congress, Berlin,fckLRGermany. Volume 12, p.148 e.v. (level 1a)
- Dr Ayush Goel, A.Prof Frank Gaillard. Double line sign 'https://radiopaedia.org/articles/double-line-sign' fckLRA.Prof Frank Gaillard. Crescent sign of avascular necrosis 'https://radiopaedia.org/articles/crescent-sign-of-avascular-necrosis-1' (level 5)
- Magee DJ. Orthopedic physical assessment. Saunders:St Louis, MO, 2008.
- WeiLiyou et al. “Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head: a randomized clinical trial”, journal of traditional Chinese medicine (2016), 36(1): 39-44 (level 1a)
- Nilsdotter A, Bremander A. “Measures of hip function and symptoms: Harris Hip Score (HHS), Hip disability and OsteoarthritisOutcome Score (HOOS), Oxford Hip Score (OHS), Lequesne Index of Severity for Osteoarthritis of the Hip (LISOH), and American Academy of Orthopedic surgeons (AAOS) Hip and Knee Questionnaire.”, Arthritis Care Res. (2011), 63 Suppl 1: S200-7 (level 5)
- Klumpp R, Trevisan C., “Aseptic osteonecrosis of the hip in the adult: current evidence on conservative treatment.” Clinical Cases in Mineral and Bone Metabolism. 2015;12(Suppl 1) (level 2a)
- Bentley, George. 2012. European Instructional. Lectures13th EFORT Congress, Berlin,fckLRGermany. Volume 12, p.148 e.v. (level 1a)
- Garino, Jonathan P., and Marvin E. Steinberg. "Total Hip Arthroplasty in Patients withfckLRAvascular Necrosis of the Femoral Head; A 2-to 10-Year Followup." Clinical orthopaedics andfckLRrelated research, 334 (1997): 108-115. (level 2a)
- Neumayr, Lynne D., et al. "Physical therapy alone compared with core decompression and physical therapy for femoral head osteonecrosis in sickle cell disease." J Bone Joint Surg Am 88.12 (2006): 2573-2582. (level 1b)
- Mass general, Total Hip Replacement, Rehabilitation & Physical Therapy Protocols 'http://www.massgeneral.org/ortho-hip-knee/patient-education/pt-ed-hiprehab.pdf' (level 5)
- Paula Miller, Treating Avascular Necrosis, Vol. 21 Issue 17, Page 23 (level 5)
- Wang C.-J., Cheng J.-H., Huang C.-C., Yip H.-K., Russo S., “Extracorporeal shockwave therapy for avascular necrosis of femoral head”, International Journal of Surgery, 2015, 24: 184-187 (level 2a)