Muscle Disorders: Difference between revisions
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'''Original Editor '''- [[User:Elaine Lonnemann]] | '''Original Editor '''- [[User:Elaine Lonnemann|Elaine Lonnemann]] | ||
'''Top Contributors '''-{{Special:Contributors/{{FULLPAGENAME}}}} | |||
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== Introduction == | |||
= | [[Muscle]] Disorders are the diseases and disorders that affect the human muscle system and their main manifestation is skeletal muscle weakness. The terms ‘muscular dystrophy’, ‘neuromuscular conditions’ and ‘neuromuscular disorders’ fall under the umbrella of the term 'Muscle Disorders'. These disorders are a large group of conditions which affect either the muscles, such as those in the arms and legs or heart and lungs, or the nerves which control the muscles<ref name="service" />. Disorders of muscle may cause weakness or paralysis in the presence of an intact nervous system. | ||
== Classification == | |||
Muscle disorders can be classified on the basis of : | |||
# Primary or secondary : Diseases and disorders as a result of direct abnormalities of the muscles are considered primary muscle diseases, Eg. [[Polymyositis]]. And Diseases that are secondary to another condition and may have caused muscle damage, Eg. diseases due to endocrine issues . | |||
# Genetic or Acquired | |||
# [[Neuromuscular Disorders|Neuromuscular]] or [[Myopathies]] | |||
== Etiology == | |||
= | Causes of muscle disorders include<ref name="service">A service of the U.S. National Library of Medicine. From the National Institutes of HealthNational Institutes of Health http://www.nlm.nih.gov/medlineplus/muscledisorders.html</ref>: | ||
*Age, hereditary | |||
*Injury or overuse, such as sprains or strains, cramps or tendinitis | |||
*A genetic disorder, such as muscular dystrophy | |||
*Some cancers | |||
*Inflammation, such as [[Myositis Ossificans of the Quadriceps|myositis]] | |||
*Diseases of nerves that affect muscle | |||
*[[Communicable Diseases|Infectious Diseases]] | |||
*Certain medicines | |||
*[[Metabolic and Endocrine Disorders|Metabolic causes]] and Endocrine causes | |||
*[[Autoimmune Disorders|Autoimmune]] disorders | |||
*Etiology may not be known at times | |||
== Symptoms == | |||
Symptoms vary with the different types of muscular disorder. | |||
'''Symptoms may include:''' | |||
# Muscle weakness that slowly gets worse. | |||
# breathing issues, especially [[Dyspnoea|dyspnea]] (shortness of breath) | |||
# dizziness, | |||
# Fatigue | |||
# Muscle wasting, loss of strength | |||
# high fever, | |||
# a stiff neck. | |||
# Numbness, tingling, or painful sensations | |||
# Double vision | |||
# Droopy eyelids | |||
# Problems with swallowing—dysphagia | |||
# Difficulty using one or more muscle groups, muscle weakness, | |||
# Problems walking, balance and frequent [[falls]]<ref name="HB">Sarnat HB. Muscular dystrophies. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics . 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 601.</ref> | |||
== Types Of Muscle Disorders == | |||
Common types of Muscle Disorders include | |||
#'''[[Myopathies]] eg''' [[Polymyositis|Polymyositis]], [[Dermatomyositis]], [[Duchenne Muscular Dystrophy|Duchenne]] Muscular Dystrophy, [[Myopathy Steroid Induced|Steroid induced myopathy]] | |||
#'''Cramp:''' prolong painful involuntary contraction of skeletal muscles | |||
#'''Fibrositis<nowiki/>:''' Inflammation of fibrous connective tissues in muscles.it also effect muscles of trunk and back.<ref name="ivyrose">ivyrose holistic http://www.ivy-rose.co.uk/HumanBody/Muscles/Muscular_Disorders.php</ref> | |||
#'''[[Myasthenia Gravis]]''' | |||
#'''[[Rhabdomyolysis]]''' | |||
#'''Cardiac Myopathy:''' [[Coronary Artery Disease (CAD)|Coronary Artery Disease]] | |||
#'''[[Amyotrophic Lateral Sclerosis]]''' | |||
#'''[[Muscle Function: Effects of Aging|Sarcopenia]]:''' This muscle disease can be primary or secondary. Sarcopenia causes muscle mass loss and muscle strength loss. | |||
== Diagnosis == | |||
= | Usually it is first suspected because of symptoms: a muscle weakness is noticed by the patient, family or a doctor.<ref name="simple">Individual & Caretaker Workbook Simple and Easy Instructionshttp://myhealth.patient.co.uk/</ref> | ||
Muscle Disorders may be diagnosed using one or more of the following tests: | |||
# An electromyography (EMG) - this is a recording of the electrical activity in a muscle. It can diagnose muscle disorders, nerve and motor problems, and degenerative diseases. | |||
# A [[Blood Tests|blood test]] : measuring specific muscle enzymes and antibodies that may be specific to one disorder or many | |||
# A muscle biopsy - this involves taking a small sample of muscle under local anaesthetic. The sample is examined under the microscope and the muscle chemicals (proteins) may be tested. | |||
# Genetic analysis - this involves testing a person's DNA using a [[Blood Physiology|blood]] sample. It can detect many (not all) cases of MD. | |||
# [[MRI Scans|MRI]]: to show abnormal muscle areas | |||
# Muscle ultrasound is used to look for suspected CMD. | |||
== Treatment == | |||
= | There is currently no cure for muscular disorders, but a variety of treatments can help manage the condition.<ref name="nhs">http://www.nhs.uk/Conditions/Muscular-dystrophy/Pages/Treatment.aspx</ref> The goals of treatment for muscle diseases may include: | ||
# treating symptoms, | |||
# delaying disease progression, and | |||
# improving quality of life. | |||
'''Medical Management''' | |||
[[Corticosteroid Medication|Corticosteroids]] taken by mouth are sometimes prescribed for reducing cramping and spasms. Immunosuppressants—drugs inhibit or prevent the overactivity of the immune system—may be given for some muscle and nerve diseases, and conditions that affect both the nerves and muscles. | |||
* Surgical corrections may be advised if needed. | |||
* The person should be as active as possible. Complete inactivity (such as bedrest) can make the disease worse.<ref name="RF">Bushby RF, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, et al. Diagnosis and management of Duchenne muscular dystrophy. Lancet Neurol . 2010;9:77-93. http://www.nytimes.com/health/guides/disease/muscular-dystrophy/overview.html</ref> | |||
== Physiotherapy Management == | |||
The physical therapist is part of multidisciplinary team and management of such disorders is long-term. | |||
The Physical therapy goals may include: | |||
* Strengthening programme | |||
* [[Pain-Modulation|Pain]] Management | |||
* Management of contractures: [[stretching]], exercises and night splints, if required | |||
* Swimming and [[Aquatherapy|hydrotherapy]] | |||
* Arranging home adaptations | |||
* [[Cardiac Rehabilitation|Cardiac]] and [[Respiratory Muscle Training|Respiratory]] Rehabilitation programme | |||
* [[Balance Training|Balance training]]<br> | |||
== Reference == | |||
<references /> | |||
[[Category:Neurological - Conditions]] | |||
[[Category:Muscular Dystrophy]] | |||
[[Category:Musculoskeletal/ | [[Category:Musculoskeletal/Orthopaedics]] | ||
[[Category:Occupational Health]] | |||
[[Category:Physiology]] | |||
[[Category:Genetic Disorders]] |
Latest revision as of 07:18, 5 March 2022
Original Editor - Elaine Lonnemann
Top Contributors -Andeela Hafeez, Kim Jackson, Rucha Gadgil, Elaine Lonnemann, Evelin Milev, Lucinda hampton, Admin, 127.0.0.1, Anil pratap tanwar, Vidya Acharya, Amrita Patro, Wendy Walker and Evan Thomas
Introduction[edit | edit source]
Muscle Disorders are the diseases and disorders that affect the human muscle system and their main manifestation is skeletal muscle weakness. The terms ‘muscular dystrophy’, ‘neuromuscular conditions’ and ‘neuromuscular disorders’ fall under the umbrella of the term 'Muscle Disorders'. These disorders are a large group of conditions which affect either the muscles, such as those in the arms and legs or heart and lungs, or the nerves which control the muscles[1]. Disorders of muscle may cause weakness or paralysis in the presence of an intact nervous system.
Classification[edit | edit source]
Muscle disorders can be classified on the basis of :
- Primary or secondary : Diseases and disorders as a result of direct abnormalities of the muscles are considered primary muscle diseases, Eg. Polymyositis. And Diseases that are secondary to another condition and may have caused muscle damage, Eg. diseases due to endocrine issues .
- Genetic or Acquired
- Neuromuscular or Myopathies
Etiology[edit | edit source]
Causes of muscle disorders include[1]:
- Age, hereditary
- Injury or overuse, such as sprains or strains, cramps or tendinitis
- A genetic disorder, such as muscular dystrophy
- Some cancers
- Inflammation, such as myositis
- Diseases of nerves that affect muscle
- Infectious Diseases
- Certain medicines
- Metabolic causes and Endocrine causes
- Autoimmune disorders
- Etiology may not be known at times
Symptoms[edit | edit source]
Symptoms vary with the different types of muscular disorder.
Symptoms may include:
- Muscle weakness that slowly gets worse.
- breathing issues, especially dyspnea (shortness of breath)
- dizziness,
- Fatigue
- Muscle wasting, loss of strength
- high fever,
- a stiff neck.
- Numbness, tingling, or painful sensations
- Double vision
- Droopy eyelids
- Problems with swallowing—dysphagia
- Difficulty using one or more muscle groups, muscle weakness,
- Problems walking, balance and frequent falls[2]
Types Of Muscle Disorders[edit | edit source]
Common types of Muscle Disorders include
- Myopathies eg Polymyositis, Dermatomyositis, Duchenne Muscular Dystrophy, Steroid induced myopathy
- Cramp: prolong painful involuntary contraction of skeletal muscles
- Fibrositis: Inflammation of fibrous connective tissues in muscles.it also effect muscles of trunk and back.[3]
- Myasthenia Gravis
- Rhabdomyolysis
- Cardiac Myopathy: Coronary Artery Disease
- Amyotrophic Lateral Sclerosis
- Sarcopenia: This muscle disease can be primary or secondary. Sarcopenia causes muscle mass loss and muscle strength loss.
Diagnosis[edit | edit source]
Usually it is first suspected because of symptoms: a muscle weakness is noticed by the patient, family or a doctor.[4]
Muscle Disorders may be diagnosed using one or more of the following tests:
- An electromyography (EMG) - this is a recording of the electrical activity in a muscle. It can diagnose muscle disorders, nerve and motor problems, and degenerative diseases.
- A blood test : measuring specific muscle enzymes and antibodies that may be specific to one disorder or many
- A muscle biopsy - this involves taking a small sample of muscle under local anaesthetic. The sample is examined under the microscope and the muscle chemicals (proteins) may be tested.
- Genetic analysis - this involves testing a person's DNA using a blood sample. It can detect many (not all) cases of MD.
- MRI: to show abnormal muscle areas
- Muscle ultrasound is used to look for suspected CMD.
Treatment[edit | edit source]
There is currently no cure for muscular disorders, but a variety of treatments can help manage the condition.[5] The goals of treatment for muscle diseases may include:
- treating symptoms,
- delaying disease progression, and
- improving quality of life.
Medical Management
Corticosteroids taken by mouth are sometimes prescribed for reducing cramping and spasms. Immunosuppressants—drugs inhibit or prevent the overactivity of the immune system—may be given for some muscle and nerve diseases, and conditions that affect both the nerves and muscles.
- Surgical corrections may be advised if needed.
- The person should be as active as possible. Complete inactivity (such as bedrest) can make the disease worse.[6]
Physiotherapy Management[edit | edit source]
The physical therapist is part of multidisciplinary team and management of such disorders is long-term.
The Physical therapy goals may include:
- Strengthening programme
- Pain Management
- Management of contractures: stretching, exercises and night splints, if required
- Swimming and hydrotherapy
- Arranging home adaptations
- Cardiac and Respiratory Rehabilitation programme
- Balance training
Reference[edit | edit source]
- ↑ 1.0 1.1 A service of the U.S. National Library of Medicine. From the National Institutes of HealthNational Institutes of Health http://www.nlm.nih.gov/medlineplus/muscledisorders.html
- ↑ Sarnat HB. Muscular dystrophies. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics . 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 601.
- ↑ ivyrose holistic http://www.ivy-rose.co.uk/HumanBody/Muscles/Muscular_Disorders.php
- ↑ Individual & Caretaker Workbook Simple and Easy Instructionshttp://myhealth.patient.co.uk/
- ↑ http://www.nhs.uk/Conditions/Muscular-dystrophy/Pages/Treatment.aspx
- ↑ Bushby RF, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, et al. Diagnosis and management of Duchenne muscular dystrophy. Lancet Neurol . 2010;9:77-93. http://www.nytimes.com/health/guides/disease/muscular-dystrophy/overview.html