Greater Trochanteric Pain Syndrome
- 1 Description
- 2 Clinically Relevant Anatomy
- 3 Aetiology
- 4 Characteristics/Clinical Presentation
- 5 Differential Diagnosis
- 6 Diagnostic Procedures
- 7 Outcome Measures
- 8 Examination
- 9 Management
- 10 Physical Therapy Management
- 11 References
Greater trochanteric pain syndrome (GTPS), also known as Greater Trochanteric Bursitis or Gluteal Tendinopathy, is a syndrome defined by tenderness to palpation over the greater trochanter with the patient in the side-lying position. GTPS refers to a chronic regional pain caused by a number of disorders of the peritrochanteric space, including structures as the trochanteric bursa, the gluteus medius,gluteus minimus tendons and the Iliotibial band. It is a combination of both gluteal (buttock) tendon injuries (tendinopathy) and bursitis (inflammation of the bursa) surrounding the hip joint. Previously, trochanteric bursitis was seen as the main pain source, but recent research indicates tendinopathy of the gluteus medius and minimus tendons are the primary local sources of lateral hip pain.(GTPS)are commonly seen in females between the ages of 40 and 60 and it is considered as cause of hip pain in 10–20% of patients presenting with hip pain to primary care, with an incidence of 1.8 patients per 1000 per year.
Clinically Relevant Anatomy
The greater trochanter is situated on the proximolateral side of the femur, just distal to the hip joint and the neck of the femur. On this bony outgrowth (=apophysis) tendons of the gluteus minimus, medius and maximus and the tensor facia latae attach. The last named muscles keep the Iliotibial band (ITB) tense. The tension could also be raised due to contraction of the Vastus lateralis, which has some fibers on the greater trochanter.
Due to contraction of these muscles there can be a lot of friction generated in the GT area. The ITB moves back and forward a lot when we walk or run. When we flex our hip the tensor fascia latae contracts and pulls the ITB forward over the GT. In the opposite direction when we extend our hip, the ITB goes backwards over the GT due to the contraction of the gluteus maximus.
Friction in the GT area is absorbed by three major bursae (trochanteric bursa, subgluteus medius bursa and subgluteus minimus bursa). These bursae locations vary greatly when observed on cadavers. There can be different amounts, different sizes and different locations of the bursae.
The hip joint is innervated by rami articulares of the obturator nerve, the femoral nerve and the sciatic nerve. Recently, researchers discovered a small sensory nerve, a branch of the n. Femoralis, that supplies the peroisteum and bursa of the greater trochanter. This discovery may be useful to improve therapies, such as interventional denervation of the greater trochanter or anatomically guided injections with corticosteroids and local anesthetics.
Several pathologies can cause greater trochanter pain syndrome.
Greater Trochanteric Pain Syndrome can be caused by direct trauma from a fall onto your side, prolonged pressure to the hip area, repetitive movements (walking/running), commencing unaccustomed vigorous exercise, weight-bearing on the one leg for long periods, hip instability or the result of a sporting injury.
Originally, they thought that an inflammation of the bursa, which is situated in the greater trochanter between the gluteus medius and minimus, was the main cause of greater trochanter pain syndrome. The inflammation of this bursa can be painful in the hip and tenderness over the upper part of the femur can occur.
After some investigation, it was discovered that the main cause of greater trochanteric pain syndrome is a pathology of the tendon of the hip abductors. More specific the gluteus medius but also gluteus minimus and tensor fascia latae can be affected. These tendons can inflame which leads to a secondary inflammation of the bursa.
The tendon pathologies are on the hip abductors which run over the great trochanter. It causes pain because of a tear or inflammation of the tendon. The tendon will degenerate and become weaker.
Another cause is the iliotibial band which also runs over the greater trochanter. Due to the tightness of the iliotibial band it can inflame and irritate the bursa associated with the gluteal tendons.
Overuse and tightness of muscles can have their origin in contact sport or traumas, as for example after a fall.
Oedema between the hip abductors and around the greater trochanter can also cause great trochanter pain syndrome.
GTPS seems to be relatively common it affects 10 to 25 % of the general population. They also concluded there is a higher prevalence of GTPS in women and in adults with ITB pain or knee OA. The syndrome mostly strikes at the age between 40 – 60. Also long distance runners are mostly affected by the syndrome.
The main symptom of GTPS is pain and tenderness along the lateral zone of the thigh. The pain may radiate down the lateral thigh and lower buttocks, but is rarely situated on the posterior thigh or distal to the knee. It can be described as aching and intense at times of greater aggravation, caused by passive, active and resisted hip abduction and external rotation.  It is often characterised by the ‘jump’ sign where palpation of the greater trochanter causes the patient to nearly jump off the bed.
- Pain is usually episodic and will worsen over time with continued aggravation.
- Pain is worse when lying on the affected side especially at night.
- Prolonged standing
- Pain following weight-bearing activities - walking, running.
- Sitting with crossed legs
- Repetitive motions
- There may be hip muscle weakness.
Often the terms Greater Trochanteric Pain Syndrome (GTPS) and Trochanteric Bursitis (TB) are used at the same time. Actually, GTPS is defined as tenderness during palpation over the greater trochanter with the patient in a side-lying position. This does not match with the term Trochanteric Bursitis, which describes the presence of an inflammation.
Even so, this is often referred to as GTPS possible because of two reasons:
- Pain in this region is often not associated with signs of inflammation such as warmth, erythema, or swelling.
- The aetiology is not fully known, this means that it can relate to myofascial pain rather than to an inflammation.
Another diagnosis in this area can make reference to the overlying tissue as the iliotibial band (ITB). This can contribute to trochanteric pain by adding stress to the area.This condition could be mistaken for common causes of hip pain including osteoarthritis of the hip, lumbar spine referred pain, and pelvic pathology.The ‘ability to put shoes and socks on’ is a useful question to differentiate GTPS from hip osteoarthritis as the patients with GTPS will not have difficulty with this task.
Also osteoarthritis of the lumbar spine, hip or knee can contribute to trochanteric pain by adding stress to the area. After investigation by Neil et al (2007), it is significantly associated with GTPS. Lower limb biomechanics can be related witch GTPS.
The diagnosis can be made firstly by physical examination of the greater trochanter. This is done by palpation of the greater trochanter with the patient in side-lying position. GTPS can be diagnosed if there is point tenderness in the posterolateral area. This pain worse with weightbearing activities and side lying at night and may be with associated radiation at lateral thigh to the knee. Pain may progressively worsen over time and be triggered or exacerbated by sudden unaccustomed exercise, falls, prolonged weightbearing, or sporting overuse (commonly long-distance running.
The following tests can be used to diagnose GTPS.
- 30-second single-leg stance test:
Standing during 30 seconds on one leg. When the patient feels pain in the hip area he has to mention it. When there is pain, the test is positive. By a study of Lequesne M. et al. the specificity were 100% and 97.3% respectively. We can conclude this test can be used for the diagnosis of Greater trochanteric pain syndrome.
- Resisted external derotation test:
The patient lies on his back with his hip and knee at a 90° angle. The hip is in external rotation. This is already painful so the patient should be asked to reduce the angle of the external rotation until the pain disappears. The patient is then asked to reposition his leg on the axis of the table whilst applying resistance. The test result is positive when the usual pain is reproduced. By a study of Lequesne M. et al the specificity were 88% and 97.3% respectively. We can conclude this test can be used for the diagnosis of greater trochanteric pain syndrome.
- Single clinical tests for GTPS lack validity however using a combination of tests can increase the diagnostic accuracy.During the consultation two that can be used are direct palpation and the single leg stance test. Direct palpation of the greater trochanter (the ‘jump sign’ as the person can be so tender they jump off the bed) carries a positive predictive value (PPV) of 83% (for positive magnetic resonance imaging [MRI] findings)if there is no pain on palpation the patient is unlikely to have GTPS. The single leg stance test (pain within 30 seconds of standing on one leg) has a very high sensitivity and PPV (100%) for positive MRI findings; if positive the patient is likely to have GTPS
- HOOS - Hip Disability and Osteoarthritis Outcome Score
- HHS - Harris Hip Score
- iHOT - International Hip Outcome Tool
Physical examination reveals point tenderness in the posterolateral area of the greater trochanter. Also, pain with passive and active internal rotation and reproduction of symptoms with resisted hip abduction.
Trendelenburg Test: This test consists of standing on one leg, the test measures the eccentric control of the gluteus medius as stabilizer of the hip and pelvis. A drop of the pelvis on the contralateral side of the stance leg indicates weakness of the ipsilateral hip abductors and results in a positive test. Test administration is demonstrated here. A study by Lequesne et al found the sensitivity and speciﬁcity to be 100% and 97.3%, respectively. This test was found to be a reliable measurement in detecting gluteus medius muscle tears as a contributor to greater trochanteric pain. Study of Hardcastle P. also shows that Trendelenburg test a significant predictor for greater trochanteric pain syndrome.
FABER Test: (flexion, abduction, external rotation): With the patient lying on his back, the physiotherapist places the hip in flexion, abduction and external rotation. A positive test reproduces anterior hip pain. If the pain is posterior, a sacroiliac issue may be the problem. In the study of M. Lequesne, this test was found a Sensitivity of 88% and a speciﬁcity of 97.3 %. Due to this results, we can conclude that the FABER test is a good test for the diagnosis of tendinopathy and bursitis in great trochanteric pain syndrome.
Noble Test: Is used to verify the Iliotibial tightness and to distinguish iliotibial tightness from outside pain of the knee, such as bicipital tendonitis, popliteus tendonitis, lateral collateral ligament strain, lateral meniscal tear or cyst, and osteoarthritis.
The patient is layed on his back in supine position. The patient knee is benched to 90 degrees
The therapist then applies pressure on the lateral femoral epicondyle. During applying of pressure the leg of the patient is extended. If pain occurs on the lateral femoral epicondyle at 30 degrees flexion the test is positive. Test administration is demonstrated here.
Modified Ober’s Test: Used to verify the Iliotibial tightness. The test consists of the patient lying on his non injured side. The therapist raises the upside hip and thigh into slight abduction. With the other hand the pelvis is stabilized to prevent flexion of the pelvis and internal rotation of the tight. Then the therapist allows the thigh to drop vertically into adduction. The test is positive if the tight does not go further than 10 degrees adduction.
Renne’s Test: This test is used to test for the ITB friction syndrome. The patient stands on the affected leg. The patient makes a squat until the knee is in 30° to 40° flexion. As the knee is in flexion, pain will increase, creating a positive result. This was tested by Renne et al (1975).
MRI provides very useful information in relation to bone and cartilage injuries, such as osteoarthritis. MRI allows a more detailed look at soft tissues (like muscles, tendons and bursae), which allows certain injuries to be excluded or confirmed. MRI can also be very effective in patients who tested positive for the Trendelenburg test (as suggested by Bird et al), and determine whether a patient is suitable for surgery.
The management of GTPS remains unclear, but the main goals of treatment are:
- Managing loads on hip joint
- Reducing compressive forces across greater trochanter
- Strengthen gluteal muscles
- Treating comorbidities.
Most of cases of GTPS can be managed in primary care with:
- Weight loss.
- Non-steroidal anti-inflammatory drugs (NSAIDs),
- Targeted physical therapy, load modification, and optimisation of biomechanics.
- Adjunct therapies include shock wave therapy and therapeutic ultrasound. Corticosteroid injection (CSI) can be effective in recalcitrant cases.
- Surgical intervention is reserved only for failed conservative management.
Removal of the bursa (also known as bursectomy):
This intervention used to be carried out by open surgery, but now it is most commonly done arthroscopically. In this operation they first split the tensor fascia latae, because it lies over the greater trochanter. Then the tension on the iliotibial band is released and the inflamed bursa is removed. In a study of Fox et al. they found that arthroscopically performed trochanteric bursectomy is a minimally invasive technique that appears to be both safe and effective for treating recalcitrant pain syndromes as GTPS.
Release of the Tractus iliotibialis:
The surgeon makes an incision at the level of the greater trochanter, and this incision will reduce the tension. This treatment has also been found to be effective but it only works on a short term. After a while the tractus will heal, and there can be a new friction due to the scar tissue.
Reduction-osteotomy of the greater trochanter:
After the incision of the tensor fascia latae, the greater trochanter is reduced by making a longitudinal incision over the greater trochanteric and slicing the bone 5 or 10 mm in thickness. Afterwards the trochanter is repositioned more distally and fixated by means of two cortical lag screws with washers. By doing so, friction between the tractus iliotibialis and the trochanter major will be strongly reduced. A study by Govaert et al., concluded that a trochanteric reduction osteotomy is a safe and effective procedure for patients with refractory GTPS who do not respond to conservative treatment.
Reconstruction of the abductor tendon:
When MRI and clinical findings are consistent with tendon disruption and weakness of the abductor tendons, surgical repair can be an option. A retrospective study by Davies et al. (2013) revealed substantial and durable improvement in strength and clinical performance after surgery in most cases. (Level IV)
Treatment with corticosteroid injections are also possible. Brinks et al. (2011) found a positive short term effect of the corticosteroid injections in primary care patients with GTPS, but on the long-term, these injections no longer had a significant effect. We can conclude that corticosteroid injections are a good solution to give patients an early relief of pain. This is done in order to break the pain cycle, to allow muscle strengthening and stretching, and to make some biomechanical adaptations to the lower extremity. By doing these corrections we are trying to remove or reduce the irritating force on the greater trochanter.
Physical Therapy Management
When GTPS is diagnosed in a patient, it is generally an overuse injury.  Treatment through physiotherapy is possible. The aim of a physical rehabilitation program is to reduce the acute or chronic pain, improve hip range of motion, improve sleep by decreasing pain with side lying and restore the overall function. 
First a wait-and-see policy is recommended. This means that the patient must rest and modify its activities (avoiding lying/sleeping on the affected area, no sitting with the legs crossed). The use of crutches or other walking aids (orthotics) may also be recommended.
The use of therapeutic modalities, manual therapy and therapeutic exercise is described below, as based on Wyss & Petal (2012):
- Ice and heat: During the acute phase, it might be useful to use ice for 20 minutes on the painful side, this every 2 or 3 hours For chronic cases, ultrasound therapy (deep heating) appears to be clinically useful in greater trochanteric pain syndrome. It had a high positive predictive value for gluteal tendon tears (positive predictive value = 1.0). Patients reported high levels of pain relief and function after surgery; tendon and bursa showed pathologic changes. 
- Low-Energy Extracorporal Shock Wave Therapy (ESWT): has been found effective for pain relief in patients witch chronic greater trochanteric pain syndrome. The intervention will not ensure that the syndrome goes away, but will provide effective pain relief. After palpation, the points of pain are localized, and are each applied with 600 shockwaves. More than one intervention is needed, as after one intervention the pain will not be reduced. 
- Iontophoresis, phonophoresis, Transcutaneous Electrical Nerve Stimulation (TENS): and cold laser are all possible therapeutic modalities that could be useful for GTPS but are not yet supported by sufficient evidence.
- Generally taken, manual therapy (deep tissue massage, myofacial release techniques, soft tissue mobilization) can be applicated to any restriction in soft tissue or joint at the hip, lumbar spine, pelvis, knee, ankle or foot in order to improve the gait, restore the normal hip mechanics and diminish the frictional force on the lateral hip. Nevertheless, more research is needed to support manual therapy as one of the additional treatments of GTPS. 
- The objective of therapeutic exercises is to improve the flexibility and strength of the affected hip. By obtaining an appropriate range of motion and muscular strengthening of the hip, the muscular balance and coordination of the buttock and hip muscles will be restored. As a result, the risk of relapsing from Greater Trochanteric Pain Syndrome can be strongly reduced.
- Many patients with GTPS experience hip joint stiffness and restricted ROM on the affected side. Restoring normal hip ROM can be achieved with active, active assisted and passive range of motion as well as stretching.
- To work on the flexibility of the hip, a stretching of the illiotibial band (IT band) and the tensor fascia latae (TFL) is performed. This ensures that the compression and rubbing on the greater trochanter reduces.  Furthermore, stretching exercises can be done to decrease length deficits of the glutei, hamstrings, quadriceps and piriformis.
- It is also needed to focus on strengthening of the hip abductors (especially the gluteus medius), external rotators end extensors, as well as the knee extensors and core muscles to improve gait, hip biomechanics and pelvic stability or control.
Sample Treatment Plan
PHASE I - Pain Relief & Protection
- Management of pain. Pain is the main a patient will seek treatment for GTPS. It is believed that pain is it the final symptom developed but should be the first symptom to improve.
- Managing pain is best achieved through relative rest, ice therapy, and techniques or exercises that unload the injured structures.
- Eliminating the compressive Load is vital to the recovery of GTPS. Encourage and educate a patient to avoid positions that lengthen the affected hip including crossing your legs, lying on either side, walking on angled surfaces and in the initial stages stretching the muscles on the outside of the hip.
- You can use an array of treatment tools to reduce pain and inflammation. These include ice, electrotherapy, acupuncture, unloading taping techniques, soft tissue massage to off-load the affected side.
- If the pain does not resolve, you can consider a local corticosteroid injection.
PHASE II - Restoring Normal ROM, Strength
- As a patients pain and inflammation settles, focus is placed on restoring normal hip joint range of motion, muscle length and resting tension, muscle strengthening and endurance, proprioception, balance and gait (walking pattern).
- Treat comorbidities- osteoarthritis, labral tears can frequently coexist.
PHASE III - Restoring Full Function
The final stage of rehabilitation is aimed at returning to desired activities and functional independence. Specific treatment goals are needed to help a patient acheive their desired outcome and retrun to baseline level of activity.
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