End Organ: Difference between revisions

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'''Original Editor '''- [[User:User Name|User Name]]
'''Original Editor '''- [[User:Lucinda hampton|Lucinda hampton]]


'''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}  &nbsp;   
'''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}  &nbsp;   
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== Introduction ==
== Introduction ==
An end organ is the last  organ affected in a chain of events, for instance a disease process.  
An end organ is the last  organ affected in a chain of events, for instance a disease process. Examples are the [[Liver Disease|liver]], [[Brain Anatomy|brain]], [[kidney]] or [[Anatomy of the Human Heart|heart.]] These organs are ultimately affected by a [[Chronic Disease|chronic]] or progressive disease or condition like [[diabetes]] or [[hypertension]] causing eg [[Chronic Kidney Disease|renal failure.]]


Examples are the liver, brain or kidney, and are ultimately affected by a chronic or progressive disease or condition like diabetes or hypertension.
== Detection ==
Timely detection of end organ damage and secondary diseases are the main determining factors of cardiovascular prognosis in patients suffering from arterial hypertension.  


== Sub Heading 2 ==
Classical pointers for end organ damage include:
A pathological change in the microcirculation plays a pivotal role in promoting end-organ dysfunction that not only predisposes to further organ damage, but also increases the risk for future macrovascular events.


* Arterial hypertensive is a risk factor for end organ damage, and can now be diagnosed early and reversed with specific and aggressive treatment.
* [[Stroke]], vascular and hemorrhagic
* Obesity is a risk factor for development of target organ damage, due to development of hypertension, and needs adressing early for prevention of such.
* Retinopathy
* Similar to arterial hypertension and obesity, type 2 diabetes mellitus is associated with target organ damage
* [[Coronary Artery Disease (CAD)|Coronary heart disease]]/[[Myocardial Infarction|myocardial infarction]] and [[Congestive Heart Failure|heart failure]]
* Proteinuria
* [[Dialysis Case Study|Renal failure]]
* [[Atherosclerosis|Atherosclerotic]] change eg stenoses and aneurysms in the blood vessels.<ref>Schmieder RE. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011179/ End organ damage in hypertension.] Deutsches Ärzteblatt International. 2010 Dec;107(49):866.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011179/ (accessed 9.5.2024)</ref>


== Sub Heading 3 ==
== Risk Factors ==
Hypertension is the largest risk factor globally for morbidity and mortality.. Timely detection of end organ damage and secondary diseases are key determinants of cardiovascular prognosis in patients suffering from arterial hypertension ([[/www.ncbi.nlm.nih.gov/pmc/articles/PMC3011179/#R2|2]]). The classic manifestations of hypertensive end organ damage include the following: vascular and hemorrhagic stroke, retinopathy, coronary heart disease/myocardial infarction and heart failure, proteinuria and renal failure and in the vasculature, atherosclerotic change including the development of stenoses and aneurysms.<ref>Schmieder RE. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011179/ End organ damage in hypertension.] Deutsches Ärzteblatt International. 2010 Dec;107(49):866.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011179/ (accessed 9.5.2024)</ref>
Many and varied and include:


== Resources  ==
# Arterial hypertensive is a risk factor for end organ damage, and can now be diagnosed early and reversed with specific and aggressive treatment.
*bulleted list
# [[Obesity]] is a risk factor for development of target organ damage, due to development of hypertension, and needs adressing early for prevention of such.
*x
# [[Diabetes Mellitus Type 2|Type 2 diabetes mellitus]] is associated with target organ damage
or
 
#numbered list
#x


== Viewing ==
Watch this 1 mi nute video with information tables regarding "Assessing damage to major organs due to hypertension".{{#ev:youtube|v=WVFbsgg1c_Q}}<ref>MediBuddy - Your Health Friend. End organ damage in Hypertension | Hypertension Update | Dr Adrija | CME Session | MediBuddy. Available from: https://www.youtube.com/watch?v=WVFbsgg1c_Q [last accessed 9.5.2024]</ref>
== References  ==
== References  ==


<references />
<references />

Latest revision as of 06:58, 10 May 2024

Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton  

Introduction[edit | edit source]

An end organ is the last organ affected in a chain of events, for instance a disease process. Examples are the liver, brain, kidney or heart. These organs are ultimately affected by a chronic or progressive disease or condition like diabetes or hypertension causing eg renal failure.

Detection[edit | edit source]

Timely detection of end organ damage and secondary diseases are the main determining factors of cardiovascular prognosis in patients suffering from arterial hypertension.

Classical pointers for end organ damage include:

Risk Factors[edit | edit source]

Many and varied and include:

  1. Arterial hypertensive is a risk factor for end organ damage, and can now be diagnosed early and reversed with specific and aggressive treatment.
  2. Obesity is a risk factor for development of target organ damage, due to development of hypertension, and needs adressing early for prevention of such.
  3. Type 2 diabetes mellitus is associated with target organ damage

Viewing[edit | edit source]

Watch this 1 mi nute video with information tables regarding "Assessing damage to major organs due to hypertension".

[2]

References[edit | edit source]

  1. Schmieder RE. End organ damage in hypertension. Deutsches Ärzteblatt International. 2010 Dec;107(49):866.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011179/ (accessed 9.5.2024)
  2. MediBuddy - Your Health Friend. End organ damage in Hypertension | Hypertension Update | Dr Adrija | CME Session | MediBuddy. Available from: https://www.youtube.com/watch?v=WVFbsgg1c_Q [last accessed 9.5.2024]