Fibrosis: Difference between revisions
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== Introduction == | == Introduction == | ||
The term fibrosis relates the development of fibrous connective tissue as a way to repair tissue following injury or damage. Pathophysiologic fibrosis, essentially an excessive accumulation of extracellular matrix components (particularly collagen), is the final result of a cascade of events following tissue injury via inflammation, and resulting in permanent scar formation. | The term fibrosis relates the development of fibrous connective tissue as a way to repair tissue following injury or damage. Pathophysiologic fibrosis, essentially an excessive accumulation of extracellular matrix components (particularly collagen), is the final result of a cascade of events following tissue injury via inflammation, and resulting in permanent scar formation. It is characterized by scarring and hardening of tissues and organs.<ref>Cellsignal Fibrosis Available:https://blog.cellsignal.com/fibrosis-when-wound-healing-turns-to-disease (accessed 18.10.2022)</ref> | ||
Fibrosis can affect all tissues of the body, and left unrestrained, can result in organ failure and death. It is caused by a process that stems from wound healing that has gone awry. Fibrogenesis is becoming increasingly recognized as a major cause of morbidity and death in most chronic inflammatory diseases, with a dearth of treatment strategies available to target the pathogenesis of fibrosis. | Fibrosis can affect all tissues of the body, and left unrestrained, can result in organ failure and death. It is caused by a process that stems from wound healing that has gone awry. Fibrogenesis is becoming increasingly recognized as a major cause of morbidity and death in most chronic inflammatory diseases, with a dearth of treatment strategies available to target the pathogenesis of fibrosis.<ref name=":0">News Medical What is Fibrosis? Available:https://www.news-medical.net/health/What-is-Fibrosis.aspx (accessed 18.10.2022)</ref> | ||
== Main Types of Fibrosis == | == Main Types of Fibrosis == | ||
Fibrosis, the excessive accumulation of fibrous connective tissue, can lead to permanent scarring, organ malfunction and, ultimately, death. This can be seen in as seen in end-stage liver disease, kidney disease, idiopathic pulmonary fibrosis, liver cirrhosis and heart failure (cardiac fibrosis). | Fibrosis, the excessive accumulation of fibrous connective tissue, can lead to permanent scarring, organ malfunction and, ultimately, death. This can be seen in as seen in end-stage liver disease, kidney disease, idiopathic pulmonary fibrosis, liver cirrhosis and heart failure (cardiac fibrosis). Fibrosis is also a. feature in the following conditions. | ||
Many chronic autoimmune | # Many chronic [[Autoimmune Disorders|autoimmune disorders]] (eg [[scleroderma]], [[Rheumatoid Arthritis|rheumatoid arthritis]], [[Crohn's Disease|Crohn’s disease]], myelofibrosis and [[Systemic Lupus Erythematosus|systemic lupus erythematosus]]).<ref name=":1">Wynn TA, Ramalingam TR. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405917/ Mechanisms of fibrosis: therapeutic translation for fibrotic disease]. Nature medicine. 2012 Jul;18(7):1028-40. Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405917/ (accessed 18.10.2022)</ref> | ||
# [[Pulmonary Fibrosis|Pulmonary fibrosis,]] as: Replacement fibrosis (as occurs in response to [[Lung Anatomy|lung]] damage caused by infarction or an infection); focal fibrosis, as occurs in a response to irritation by inhaled substances that are inhaled eg [[Role of Pulmonary Rehabilitation in Silicosis|silica]] or [[Mesothelioma|asbestos]]; diffuse parenchymal lung disease (DPLD).<ref name=":0" /> | |||
Pulmonary fibrosis, as: Replacement fibrosis | # Skeletal [[Muscle Injuries|muscle injuries]]: With minor injuries the muscles are able to regenerate completely and recover their usual capabilities. However, in severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue.<ref>Gardner T, Kenter K, Li Y. [https://www.hindawi.com/journals/jsm/2020/7059057/#conclusion Fibrosis following acute skeletal muscle Injury: mitigation and reversal potential in the clinic]. Journal of Sports Medicine. 2020 Sep 1;2020. Available:https://www.hindawi.com/journals/jsm/2020/7059057/#conclusion (accessed 18.10.2022)</ref> | ||
# Fibrosis is a feature of metastasis, chronic graft rejection and the pathogenesis of many progressive [[myopathies]].<ref name=":1" /> | |||
Skeletal muscle injuries: With minor injuries the muscles are able to regenerate completely and recover their usual capabilities. However, in severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue. | |||
Fibrosis is a feature of | |||
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Revision as of 09:02, 18 October 2022
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton and Vidya Acharya
Introduction[edit | edit source]
The term fibrosis relates the development of fibrous connective tissue as a way to repair tissue following injury or damage. Pathophysiologic fibrosis, essentially an excessive accumulation of extracellular matrix components (particularly collagen), is the final result of a cascade of events following tissue injury via inflammation, and resulting in permanent scar formation. It is characterized by scarring and hardening of tissues and organs.[1]
Fibrosis can affect all tissues of the body, and left unrestrained, can result in organ failure and death. It is caused by a process that stems from wound healing that has gone awry. Fibrogenesis is becoming increasingly recognized as a major cause of morbidity and death in most chronic inflammatory diseases, with a dearth of treatment strategies available to target the pathogenesis of fibrosis.[2]
Main Types of Fibrosis[edit | edit source]
Fibrosis, the excessive accumulation of fibrous connective tissue, can lead to permanent scarring, organ malfunction and, ultimately, death. This can be seen in as seen in end-stage liver disease, kidney disease, idiopathic pulmonary fibrosis, liver cirrhosis and heart failure (cardiac fibrosis). Fibrosis is also a. feature in the following conditions.
- Many chronic autoimmune disorders (eg scleroderma, rheumatoid arthritis, Crohn’s disease, myelofibrosis and systemic lupus erythematosus).[3]
- Pulmonary fibrosis, as: Replacement fibrosis (as occurs in response to lung damage caused by infarction or an infection); focal fibrosis, as occurs in a response to irritation by inhaled substances that are inhaled eg silica or asbestos; diffuse parenchymal lung disease (DPLD).[2]
- Skeletal muscle injuries: With minor injuries the muscles are able to regenerate completely and recover their usual capabilities. However, in severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue.[4]
- Fibrosis is a feature of metastasis, chronic graft rejection and the pathogenesis of many progressive myopathies.[3]
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Resources[edit | edit source]
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References[edit | edit source]
- ↑ Cellsignal Fibrosis Available:https://blog.cellsignal.com/fibrosis-when-wound-healing-turns-to-disease (accessed 18.10.2022)
- ↑ 2.0 2.1 News Medical What is Fibrosis? Available:https://www.news-medical.net/health/What-is-Fibrosis.aspx (accessed 18.10.2022)
- ↑ 3.0 3.1 Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nature medicine. 2012 Jul;18(7):1028-40. Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405917/ (accessed 18.10.2022)
- ↑ Gardner T, Kenter K, Li Y. Fibrosis following acute skeletal muscle Injury: mitigation and reversal potential in the clinic. Journal of Sports Medicine. 2020 Sep 1;2020. Available:https://www.hindawi.com/journals/jsm/2020/7059057/#conclusion (accessed 18.10.2022)
