Evidence-Based Practice in Tendinopathy: Difference between revisions

No edit summary
No edit summary
Line 2: Line 2:


== Introduction ==
== Introduction ==
[[File:EBP.png|thumb]]
[[File:EBP.png|thumb|Figure 1. Components of evidence-based practice.]]
[[Evidence Based Practice (EBP)|Evidence-based practice]] is about integrating the "best research evidence with clinical expertise and client preferences."<ref>Scurlock-Evans L, Upton P, Upton D. [https://www.researchgate.net/profile/Dominic_Upton/publication/260806861_Evidence-Based_Practice_in_Physiotherapy_a_systematic_review_of_barriers_enablers_and_interventions/links/5a17988e0f7e9be37f9590d4/Evidence-Based-Practice-in-Physiotherapy-a-systemat Evidence-based practice in physiotherapy: a systematic review of barriers, enablers and interventions.] Physiotherapy. 2014 Sep 1;100(3):208-19.</ref> Applying an evidence-based practice approach to the management of [[tendinopathy]] is not as simple as applying one set of research findings, from a single article, in a recipe format for a patient.  Every patient presents with a unique clinical picture. The therapist managing the patient should apply a broad base of evidence to clinically reason a comprehensive management plan. It is important that management is not recipe-driven but should be based on the best evidence available at that time. Evidence-based practice is fluid and constantly changes as more evidence is produced.
[[Evidence Based Practice (EBP)|Evidence-based practice]] is about integrating the "best research evidence with clinical expertise and client preferences."<ref>Scurlock-Evans L, Upton P, Upton D. [https://www.researchgate.net/profile/Dominic_Upton/publication/260806861_Evidence-Based_Practice_in_Physiotherapy_a_systematic_review_of_barriers_enablers_and_interventions/links/5a17988e0f7e9be37f9590d4/Evidence-Based-Practice-in-Physiotherapy-a-systemat Evidence-based practice in physiotherapy: a systematic review of barriers, enablers and interventions.] Physiotherapy. 2014 Sep 1;100(3):208-19.</ref> Applying an evidence-based practice approach to the management of [[tendinopathy]] is not as simple as applying one set of research findings from a single article in a recipe format for a patient.
 
Every patient presents with a unique clinical picture. The therapist managing the patient should apply a broad base of evidence to clinically reason a comprehensive management plan. This plan should be based on the best evidence available at that time. Evidence-based practice is fluid and constantly changes as more evidence is produced.


== Tendinopathy ==
== Tendinopathy ==
Painful conditions that emerge around or in tendons in response to overuse is called tendinopathy. The pathology of tendinopathy is multifactoral, complex and remains difficult to treat. <ref>Challoumas D, Biddle M, Millar NL. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886058/ Recent advances in tendinopathy]. Faculty Reviews. 2020;9.</ref>Tendinopathies are delineated as a non-rupture damage in the tendon which is magnified with mechanical loading.  The difference between tendinitis and tendinopathy is the latter generally do not present with inflammation.<ref>Canosa-Carro, L., Bravo-Aguilar, M., Abuín-Porras, V., Almazán-Polo, J., García-Pérez-de-Sevilla, G., Rodríguez-Costa, I., López-López, D., Navarro-Flores, E. and Romero-Morales, C., 2022. [https://www.sciencedirect.com/science/article/pii/S0011502921001905 Current understanding of the diagnosis and management of the tendinopathy: An update from the lab to the clinical practice.] ''Disease-a-Month'', ''68''(10), p.101314.</ref>Tendinopathy presents with chronic pain, decreased physical function, reduced participation in activities and account for up to 50% of all musculoskeletal disorders.<ref>Burton I. Autoregulation in resistance training for lower limb tendinopathy: [https://www.frontiersin.org/articles/10.3389/fphys.2021.704306/full A potential method for addressing individual factors, intervention issues, and inadequate outcomes]. Frontiers in Physiology. 2021;12.</ref>
Painful conditions that emerge around or in tendons in response to overuse are called tendinopathies. In general, tendinopathies are complex and multifaceted. They are associated with pain, decreased function, and reduced exercise tolerance, and they can be difficult to treat.<ref>Millar NL, Silbernagel KG, Thorborg K, Kirwan PD, Galatz LM, Abrams GD et al. Tendinopathy. Nat Rev Dis Primers. 2021 Jan 7;7(1):1.</ref><ref>Challoumas D, Biddle M, Millar NL. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886058/ Recent advances in tendinopathy]. Faculty Reviews. 2020;9.</ref> They are delineated as non-rupture damage in the tendon, which is magnified with mechanical loading.<ref>Canosa-Carro, L., Bravo-Aguilar, M., Abuín-Porras, V., Almazán-Polo, J., García-Pérez-de-Sevilla, G., Rodríguez-Costa, I., López-López, D., Navarro-Flores, E. and Romero-Morales, C., 2022. [https://www.sciencedirect.com/science/article/pii/S0011502921001905 Current understanding of the diagnosis and management of the tendinopathy: An update from the lab to the clinical practice.] ''Disease-a-Month'', ''68''(10), p.101314.</ref>
 
For more information on key features of tendinopathy that can help with a differential diagnosis, please see: [[Differential Diagnosis of Tendinopathy]].


== The Challenge of Evidence-Based Practice in Tendons ==
== The Challenge of Evidence-Based Practice in Tendons ==
Line 12: Line 16:
* In research settings, it is important to control as many variables as possible, so the results can be as accurate as possible.  
* In research settings, it is important to control as many variables as possible, so the results can be as accurate as possible.  
* Researchers often only look at one parameter and measure that parameter over a specific period of time.  
* Researchers often only look at one parameter and measure that parameter over a specific period of time.  
* It is impossible in a research setting to apply an entire rehabilitation programme as an intervention and long term follow up is often difficult.  
* It is impossible in a research setting to apply an entire rehabilitation programme as an intervention, and long-term follow-up is often difficult.
* Strong clinical reasoning skills are required to synthesise all the evidence available into clinically appropriate management strategies.
* Strong clinical reasoning skills are required to synthesise all the evidence available into clinically appropriate management strategies.


== Tailor protocols to the individual patient ==
== Tailor Protocols to the Individual ==
Every patient presents with a unique set of symptoms. It is a physiotherapists responsibility to perform a thorough assessment and then clinically reason the assessment findings to get a complete clinical picture. Because research needs to be specific, it is uncommon that a paper can be directly applied to a patient. Concepts and aspects of protocols within papers need to be modified and tailored for where the patient is at this the point of their journey to recovery.<ref>Rio E. Evidence-Based Practice in Tendinopathy. Plus. 2020</ref>
Every patient presents with a unique set of symptoms. It is the physiotherapist's responsibility to perform a thorough assessment and then clinically reason the assessment findings to get a complete clinical picture. Because research needs to be specific, research papers often cannot be directly applied to a patient. Concepts and aspects of protocols within papers need to be modified and tailored based on where the patient is at this point in their journey to recovery.<ref>Rio E. [https://members.physio-pedia.com/evidence-based-practice-in-tendinopathy-course/ Evidence-Based Practice in Tendinopathy Course]. Plus, 2020.</ref>
* It is important to always consider the person who is in front and to compare that to the demographics of the groups contained within a research paper. Is it applicable that an intervention that worked for older men would be appropriate for younger females?
* A study by Rio et al, in 2015, it all showed that isometric exercises reduced pain in patellar tendinopathy which has promising applications for clinical practice<ref>Ebonie Rio, Dawson Kidgell, Craig Purdam, Jamie Gaida, G Lorimer Moseley, Alan J Pearce, Jill Cook. [http://bjsm.bmj.com/content/49/19/1277.abstract?cited-by=yes&legid=bjsports;49/19/1277 Isometric exercise induces analgesia and reduces inhibition in patellar tendinopathy]. Br J Sports Med 2015;49:1277–1283.</ref>. However, the study was conducted on young athletic men with stringent exclusion criteria and as such, should be applied to a more general population with caution. A situation such as this is where the clinical experience component of evidence-based practice is so important.  A clinician needs to synthesise the best evidence available in research and adapt it into a management plan appropriate for the patient in front of them factoring the patient’s demographics and clinical findings.


== Read outside of tendon literature ==
It is important to always consider the person who is in front of you and to compare that to the demographics of the groups contained within a research paper. For example, is an intervention that worked for older men appropriate for younger females?
* There are many aspects to treating a patient outside of the specific diagnosis.  
 
* In a tendinopathy patient, you are dealing with a person as a whole.
A 2015 study by Rio et al.<ref name=":3" /> found that isometric exercises reduced pain in patellar tendinopathy. While this has promising applications for clinical practice,<ref name=":3">Ebonie Rio, Dawson Kidgell, Craig Purdam, Jamie Gaida, G Lorimer Moseley, Alan J Pearce, Jill Cook. [http://bjsm.bmj.com/content/49/19/1277.abstract?cited-by=yes&legid=bjsports;49/19/1277 Isometric exercise induces analgesia and reduces inhibition in patellar tendinopathy]. Br J Sports Med 2015;49:1277–1283.</ref> the study was conducted on young athletic men with stringent exclusion criteria. Therefore, we need to be cautious when applying these findings to a more general population and also consider the importance of clinical experience in evidence-based practice (see Figure 1). Clinicians need to synthesise the best evidence available in research and adapt it to create a management plan that is appropriate for the patient in front of them. This plan must factor in the patient’s demographics and clinical findings.
* It is useful to look more broadly at the literature around subjects such as: [[Communication Skills|communication]]; [[Pain Neuroscience Education (PNE)|pain neuroscience;]] cross-education; and general [[Strength and Conditioning|strengthening]].
 
* Synthesising all this information will help you to provide a holistically informed evidence-based practice approach
== Reading Outside of Tendon Literature ==
There are many aspects to treating a patient outside of the specific diagnosis. For individuals with tendinopathy, you must consider the person as a whole. It is useful to look more broadly at the literature on subjects such as [[Communication Skills|communication]], [[Pain Neuroscience Education (PNE)|pain neuroscience]], cross-education, and general [[Strength and Conditioning|strengthening]]. Synthesising all this information will help you to provide a holistically-informed evidence-based practice approach.


== Consider Comorbidities ==
== Consider Comorbidities ==
Tendinopathies do not occur in isolation. A person may present with a variety of comorbidities that can affect the outcomes. When applying specific research protocols to a patient, it is important to factor in their comorbidities. eg.
Tendinopathies do not occur in isolation. A person may present with a variety of comorbidities that can affect outcomes. When applying specific research protocols, it is important to factor in their comorbidities. For example:
* A [[Diabetes|diabetic]] patient may not follow the standard trajectory of healing times
* a patient with [[diabetes]] may not follow the standard trajectory of healing times
* A person with a systemic inflammatory condition such as [[Rheumatoid Arthritis|rheumatoid arthritis]] may not respond as positively to a loading protocol.
* a person with a systemic inflammatory condition such as [[Rheumatoid Arthritis|rheumatoid arthritis]] may not respond as positively to a loading protocol
* Even though it may not be very common, symptomatic patellar tendinopathy has been found to sometimes be associated with connective tissue diseases like psoriatic arthritis or diabetes, or metabolic or autoimmune diseases. <ref name=":2">Malliaras P, Cook J, Purdam C, Rio E. [https://www.jospt.org/doi/pdfplus/10.2519/jospt.2015.5987 Patellar tendinopathy: clinical diagnosis, load management, and advice for challenging case presentations]. journal of orthopaedic & sports physical therapy. 2015 Nov;45(11):887-98.</ref>   
* while this is less common, symptomatic patellar tendinopathy can be associated with other conditions like psoriatic arthritis, diabetes, and metabolic or autoimmune diseases.<ref name=":2">Malliaras P, Cook J, Purdam C, Rio E. [https://www.jospt.org/doi/pdfplus/10.2519/jospt.2015.5987 Patellar tendinopathy: clinical diagnosis, load management, and advice for challenging case presentations]. journal of orthopaedic & sports physical therapy. 2015 Nov;45(11):887-98.</ref>   
Patients should be screened during the assessment to rule out systemic comorbidities especially when an increase in load does not form part of the clinical picture.
Patients should be screened during the assessment to rule out systemic comorbidities, especially when an increase in load does not form part of the clinical picture. A referral for medical management alongside physiotherapy is important for these patients.<ref name=":2" />
* Referral for medical management alongside physiotherapy is important with these patients. <ref name=":2" />  
 
== Consider Patient Preferences ==
== Consider Patient Preferences ==
It is important that patients expectations, as well as personal preferences, are taken into account when developing a management plan.  
We must also consider our patients' expectations and personal preferences when developing a management plan.  
* Every person has different goals, and these should be incorporated into the treatment plan.
* Every person has different goals, and these should be incorporated into the treatment plan
* A [[Patient Engagement|patient-centred]] approach is important to ensure patient compliance as well as enhancing the therapeutic relationship.<ref name=":0">Fix GM, VanDeusen Lukas C, Bolton RE, Hill JN, Mueller N, LaVela SL, Bokhour BG. [https://onlinelibrary.wiley.com/doi/pdf/10.1111/hex.12615 Patient‐centred care is a way of doing things: How healthcare employees conceptualize patient‐centred care. Health Expectations]. 2018 Feb;21(1):300-7.</ref>
* A [[Patient Engagement|patient-centred]] approach is important to ensure patient compliance as well as enhancing the therapeutic relationship<ref name=":0">Fix GM, VanDeusen Lukas C, Bolton RE, Hill JN, Mueller N, LaVela SL, Bokhour BG. [https://onlinelibrary.wiley.com/doi/pdf/10.1111/hex.12615 Patient‐centred care is a way of doing things: How healthcare employees conceptualize patient‐centred care. Health Expectations]. 2018 Feb;21(1):300-7.</ref>


== Application of Tendon Research ==
== Application of Tendon Research ==


Applying tendon research to patients doesn't need to be complicated.  
Applying tendon research in clinical practice doesn't need to be complicated.  


Our primary goal should always be to assess for function and functional deficits as well as the patient's ideas, concerns and expectations. A patient-centred approach is always the best management strategy.<ref name=":0" />  
Our primary goal should always be to assess for function and functional deficits, as well as the patient's ideas, concerns and expectations. A patient-centred approach is always the best management strategy.<ref name=":0" />  
* The research consistently shows that rehabilitation of tendinopathies should focus on slow progressive loading.<ref name=":1" /><ref>Muaidi QI. Rehabilitation of patellar tendinopathy. ''J Musculoskelet Neuronal Interact''. 2020;20(4):535-40.</ref><ref>Mascaró A, Cos M, Antoni M, Roig A, Purdam C, Cook J. Load management in tendinopathy: Clinical progression for Achilles and patellar tendinopathy. Apunts. Medicina de l'Esport. 2018; 53:19-27.</ref> The ideal [[Therapeutic Exercise|exercise]] programme and prescription are still to be determined and it is possible that people with varying ages, activity levels, access to equipment and site of tendinopathy will respond to varying protocols. <ref name=":1">Cardoso TB, Pizzari T, Kinsella R, Hope D, Cook JL. [https://www.sciencedirect.com/science/article/pii/S1521694219300233 Current trends in tendinopathy management.] Best Practice & Research Clinical Rheumatology. 2019 Feb 1;33(1):122-40</ref>
* The research consistently shows that rehabilitation of tendinopathies should focus on slow, progressive loading.<ref name=":1" /><ref>Muaidi QI. Rehabilitation of patellar tendinopathy. ''J Musculoskelet Neuronal Interact''. 2020;20(4):535-40.</ref><ref>Mascaró A, Cos M, Antoni M, Roig A, Purdam C, Cook J. Load management in tendinopathy: Clinical progression for Achilles and patellar tendinopathy. Apunts. Medicina de l'Esport. 2018; 53:19-27.</ref> The ideal [[Therapeutic Exercise|exercise]] programme and prescription are still to be determined. People may respond in different ways to protocols based on their age, site of tendinopathy, activity levels and access to equipment.<ref name=":1">Cardoso TB, Pizzari T, Kinsella R, Hope D, Cook JL. [https://www.sciencedirect.com/science/article/pii/S1521694219300233 Current trends in tendinopathy management.] Best Practice & Research Clinical Rheumatology. 2019 Feb 1;33(1):122-40</ref>
* Always consider the patient's individual goals and manage them according to where they are at that exact point of time. A 60-year-old sedentary woman with patellar tendinopathy will have very different goals and expectations compared to a 25-year-old professional volleyball player.
* Always consider the patient's individual goals and manage them according to where they are at that exact point in time. A 60-year-old sedentary woman with patellar tendinopathy will have very different goals and expectations than a 25-year-old professional volleyball player.
* Isolated training towards the rehabilitation of a specific tendon or muscle group may be effective but if a return to sport is the end goal a much more comprehensive rehabilitation programme of the entire kinetic chain is required. <ref>Abat F, Alfredson H, Cucchiarini M, Madry H, Marmotti A, Mouton C, Oliveira JM, Pereira H, Peretti GM, Romero-Rodriguez D, Spang C. [https://www.biomedcentral.com/openurl?doi=10.1186/s40634-017-0092-6 Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach.] Journal of experimental orthopaedics. 2017 Dec;4(1):1-1.</ref><ref name=":1" />
* Isolated training to rehabilitate a specific tendon or muscle group may be effective, but if a return to sport is the end goal, a much more comprehensive rehabilitation programme of the entire kinetic chain is required.<ref>Abat F, Alfredson H, Cucchiarini M, Madry H, Marmotti A, Mouton C, Oliveira JM, Pereira H, Peretti GM, Romero-Rodriguez D, Spang C. [https://www.biomedcentral.com/openurl?doi=10.1186/s40634-017-0092-6 Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach.] Journal of experimental orthopaedics. 2017 Dec;4(1):1-1.</ref><ref name=":1" />


== General Summary of EBP in tendons ==
== General Summary of Evidence-Based Practice in Tendons ==
* Always consider a patient’s functional state
* Always consider a patient’s functional state
* Assess their current capacity as well as current goals and for a treatment plan based around them
* Assess their current capacity as well as current goals and for a treatment plan based around them
* Slow [[Load Management|progressive loading]] (tendons do not like fast changes)
* Slow [[Load Management|progressive loading]] (tendons do not like fast changes)
* Consider their current situation eg are they in-season or out of season
* Consider the patient's current situation (e.g. are they in-season or out-of-season)
* Patient-centred approach - make sure what you are giving them aligns with their values, beliefs, expectations and capacity
* Ensure you adopt a patient-centred approach - make sure that what you are giving them aligns with their values, beliefs, expectations and capacity
{{#ev:youtube| BAPFnUZYMec}}
{{#ev:youtube| BAPFnUZYMec}}



Revision as of 23:49, 31 October 2023

Introduction[edit | edit source]

Figure 1. Components of evidence-based practice.

Evidence-based practice is about integrating the "best research evidence with clinical expertise and client preferences."[1] Applying an evidence-based practice approach to the management of tendinopathy is not as simple as applying one set of research findings from a single article in a recipe format for a patient.

Every patient presents with a unique clinical picture. The therapist managing the patient should apply a broad base of evidence to clinically reason a comprehensive management plan. This plan should be based on the best evidence available at that time. Evidence-based practice is fluid and constantly changes as more evidence is produced.

Tendinopathy[edit | edit source]

Painful conditions that emerge around or in tendons in response to overuse are called tendinopathies. In general, tendinopathies are complex and multifaceted. They are associated with pain, decreased function, and reduced exercise tolerance, and they can be difficult to treat.[2][3] They are delineated as non-rupture damage in the tendon, which is magnified with mechanical loading.[4]

For more information on key features of tendinopathy that can help with a differential diagnosis, please see: Differential Diagnosis of Tendinopathy.

The Challenge of Evidence-Based Practice in Tendons[edit | edit source]

There is a plethora of research available on tendons and tendinopathy, and it can be difficult to translate that evidence directly into clinical practice.

  • In research settings, it is important to control as many variables as possible, so the results can be as accurate as possible.
  • Researchers often only look at one parameter and measure that parameter over a specific period of time.
  • It is impossible in a research setting to apply an entire rehabilitation programme as an intervention, and long-term follow-up is often difficult.
  • Strong clinical reasoning skills are required to synthesise all the evidence available into clinically appropriate management strategies.

Tailor Protocols to the Individual[edit | edit source]

Every patient presents with a unique set of symptoms. It is the physiotherapist's responsibility to perform a thorough assessment and then clinically reason the assessment findings to get a complete clinical picture. Because research needs to be specific, research papers often cannot be directly applied to a patient. Concepts and aspects of protocols within papers need to be modified and tailored based on where the patient is at this point in their journey to recovery.[5]

It is important to always consider the person who is in front of you and to compare that to the demographics of the groups contained within a research paper. For example, is an intervention that worked for older men appropriate for younger females?

A 2015 study by Rio et al.[6] found that isometric exercises reduced pain in patellar tendinopathy. While this has promising applications for clinical practice,[6] the study was conducted on young athletic men with stringent exclusion criteria. Therefore, we need to be cautious when applying these findings to a more general population and also consider the importance of clinical experience in evidence-based practice (see Figure 1). Clinicians need to synthesise the best evidence available in research and adapt it to create a management plan that is appropriate for the patient in front of them. This plan must factor in the patient’s demographics and clinical findings.

Reading Outside of Tendon Literature[edit | edit source]

There are many aspects to treating a patient outside of the specific diagnosis. For individuals with tendinopathy, you must consider the person as a whole. It is useful to look more broadly at the literature on subjects such as communication, pain neuroscience, cross-education, and general strengthening. Synthesising all this information will help you to provide a holistically-informed evidence-based practice approach.

Consider Comorbidities[edit | edit source]

Tendinopathies do not occur in isolation. A person may present with a variety of comorbidities that can affect outcomes. When applying specific research protocols, it is important to factor in their comorbidities. For example:

  • a patient with diabetes may not follow the standard trajectory of healing times
  • a person with a systemic inflammatory condition such as rheumatoid arthritis may not respond as positively to a loading protocol
  • while this is less common, symptomatic patellar tendinopathy can be associated with other conditions like psoriatic arthritis, diabetes, and metabolic or autoimmune diseases.[7]

Patients should be screened during the assessment to rule out systemic comorbidities, especially when an increase in load does not form part of the clinical picture. A referral for medical management alongside physiotherapy is important for these patients.[7]

Consider Patient Preferences[edit | edit source]

We must also consider our patients' expectations and personal preferences when developing a management plan.

  • Every person has different goals, and these should be incorporated into the treatment plan
  • A patient-centred approach is important to ensure patient compliance as well as enhancing the therapeutic relationship[8]

Application of Tendon Research[edit | edit source]

Applying tendon research in clinical practice doesn't need to be complicated.

Our primary goal should always be to assess for function and functional deficits, as well as the patient's ideas, concerns and expectations. A patient-centred approach is always the best management strategy.[8]

  • The research consistently shows that rehabilitation of tendinopathies should focus on slow, progressive loading.[9][10][11] The ideal exercise programme and prescription are still to be determined. People may respond in different ways to protocols based on their age, site of tendinopathy, activity levels and access to equipment.[9]
  • Always consider the patient's individual goals and manage them according to where they are at that exact point in time. A 60-year-old sedentary woman with patellar tendinopathy will have very different goals and expectations than a 25-year-old professional volleyball player.
  • Isolated training to rehabilitate a specific tendon or muscle group may be effective, but if a return to sport is the end goal, a much more comprehensive rehabilitation programme of the entire kinetic chain is required.[12][9]

General Summary of Evidence-Based Practice in Tendons[edit | edit source]

  • Always consider a patient’s functional state
  • Assess their current capacity as well as current goals and for a treatment plan based around them
  • Slow progressive loading (tendons do not like fast changes)
  • Consider the patient's current situation (e.g. are they in-season or out-of-season)
  • Ensure you adopt a patient-centred approach - make sure that what you are giving them aligns with their values, beliefs, expectations and capacity

Additional Resources[edit | edit source]

References[edit | edit source]

  1. Scurlock-Evans L, Upton P, Upton D. Evidence-based practice in physiotherapy: a systematic review of barriers, enablers and interventions. Physiotherapy. 2014 Sep 1;100(3):208-19.
  2. Millar NL, Silbernagel KG, Thorborg K, Kirwan PD, Galatz LM, Abrams GD et al. Tendinopathy. Nat Rev Dis Primers. 2021 Jan 7;7(1):1.
  3. Challoumas D, Biddle M, Millar NL. Recent advances in tendinopathy. Faculty Reviews. 2020;9.
  4. Canosa-Carro, L., Bravo-Aguilar, M., Abuín-Porras, V., Almazán-Polo, J., García-Pérez-de-Sevilla, G., Rodríguez-Costa, I., López-López, D., Navarro-Flores, E. and Romero-Morales, C., 2022. Current understanding of the diagnosis and management of the tendinopathy: An update from the lab to the clinical practice. Disease-a-Month, 68(10), p.101314.
  5. Rio E. Evidence-Based Practice in Tendinopathy Course. Plus, 2020.
  6. 6.0 6.1 Ebonie Rio, Dawson Kidgell, Craig Purdam, Jamie Gaida, G Lorimer Moseley, Alan J Pearce, Jill Cook. Isometric exercise induces analgesia and reduces inhibition in patellar tendinopathy. Br J Sports Med 2015;49:1277–1283.
  7. 7.0 7.1 Malliaras P, Cook J, Purdam C, Rio E. Patellar tendinopathy: clinical diagnosis, load management, and advice for challenging case presentations. journal of orthopaedic & sports physical therapy. 2015 Nov;45(11):887-98.
  8. 8.0 8.1 Fix GM, VanDeusen Lukas C, Bolton RE, Hill JN, Mueller N, LaVela SL, Bokhour BG. Patient‐centred care is a way of doing things: How healthcare employees conceptualize patient‐centred care. Health Expectations. 2018 Feb;21(1):300-7.
  9. 9.0 9.1 9.2 Cardoso TB, Pizzari T, Kinsella R, Hope D, Cook JL. Current trends in tendinopathy management. Best Practice & Research Clinical Rheumatology. 2019 Feb 1;33(1):122-40
  10. Muaidi QI. Rehabilitation of patellar tendinopathy. J Musculoskelet Neuronal Interact. 2020;20(4):535-40.
  11. Mascaró A, Cos M, Antoni M, Roig A, Purdam C, Cook J. Load management in tendinopathy: Clinical progression for Achilles and patellar tendinopathy. Apunts. Medicina de l'Esport. 2018; 53:19-27.
  12. Abat F, Alfredson H, Cucchiarini M, Madry H, Marmotti A, Mouton C, Oliveira JM, Pereira H, Peretti GM, Romero-Rodriguez D, Spang C. Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach. Journal of experimental orthopaedics. 2017 Dec;4(1):1-1.