The Physiotherapy Management of Thalassaemia and Sickle Cell Anaemia: Difference between revisions
No edit summary |
No edit summary |
||
| Line 10: | Line 10: | ||
Thalassemia is derived from the Greek word "Thalassa" which means <nowiki>''sea''. It's also referred to as ''Mediterranean Anaemia''</nowiki>. It mainly affects individuals originating from the Mediterranean area, Middle East, Transcaucasia, Central Asia, Indian subcontinent, and Southeast Asia<ref name=":0">Kora A. The Physiotherapy Management of Thalassaemia and Sickle Cell Anaemia. Physioplus Course 2020</ref>. | Thalassemia is derived from the Greek word "Thalassa" which means <nowiki>''sea''. It's also referred to as ''Mediterranean Anaemia''</nowiki>. It mainly affects individuals originating from the Mediterranean area, Middle East, Transcaucasia, Central Asia, Indian subcontinent, and Southeast Asia<ref name=":0">Kora A. The Physiotherapy Management of Thalassaemia and Sickle Cell Anaemia. Physioplus Course 2020</ref>. | ||
There are two types of Thalassaemia: α- and β- and complex thalassemias depending on the type of the involved globin chain. The incidence rate is about 4.4 of every 10000 live births globally and approximately about 5% of all population<ref name=":0" />. | There are two types of Thalassaemia: α- and β- and complex thalassemias depending on the type of the involved globin chain. Alpha Thalassaemia is developed when the alpha gene is affected and likewise, in beta-thalassemia, the globin chain is affected or the abnormal haemoglobin involved is beta-globin gen<ref name=":1">Aszhari FR, Rustam Z, Subroto F, Semendawai AS. Classification of thalassemia data using random forest algorithm. InJournal of Physics: Conference Series 2020 Mar 1 (Vol. 1490, No. 1, p. 012050). IOP Publishing.</ref>. | ||
The incidence rate is about 4.4 of every 10000 live births globally and approximately about 5% of all population<ref name=":0" />. | |||
It has been estimated that the globally there are 9million carriers of Thalassaemia and Sickle cell anaemia become pregnant each year<ref>Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bulletin of the World Health Organization. 2008;86:480-7.</ref>. | It has been estimated that the globally there are 9million carriers of Thalassaemia and Sickle cell anaemia become pregnant each year<ref>Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bulletin of the World Health Organization. 2008;86:480-7.</ref>. | ||
{{#ev:youtube|JxuupecxHO8}}<ref>What is Thalassemia? . Available from:https://www.youtube.com/watch?v=JxuupecxHO8[last accessed 30/09/2020]</ref> | {{#ev:youtube|JxuupecxHO8}}<ref>What is Thalassemia? . Available from:https://www.youtube.com/watch?v=JxuupecxHO8[last accessed 30/09/2020]</ref> | ||
'''Clinically,''' Thalassemia is classified into three forms<ref name=":1" />: | |||
* Thalassemia major: this is a severe form of anaemia where patients need continuous blood transfusions throughout their lives. | |||
* Thalassemia intermedia: mild to moderate anaemia, patients occasionally need blood transfusions | |||
* Thalassemia minor or trait: patients have mild symptoms and they usually don’t need blood transfusions | |||
== Sickle Cell Anaemia == | == Sickle Cell Anaemia == | ||
Revision as of 16:44, 30 September 2020
Original Editors - Mariam Hashem
Top Contributors - Mariam Hashem, Kim Jackson, Tarina van der Stockt, Lucinda hampton, Jess Bell, Aminat Abolade and Stacy Schiurring
Thalassaemia[edit | edit source]
Thalassaemia is one of the most common inherited diseases worldwide. It is defined as an autosomal recessive blood disorder that results from reduction or absence in the production of globin chains that make up the haemoglobin (Hb) leading to abnormal destruction of erythrocytes and consequently decreased oxygen delivery[1].
Thalassemia is derived from the Greek word "Thalassa" which means ''sea''. It's also referred to as ''Mediterranean Anaemia''. It mainly affects individuals originating from the Mediterranean area, Middle East, Transcaucasia, Central Asia, Indian subcontinent, and Southeast Asia[2].
There are two types of Thalassaemia: α- and β- and complex thalassemias depending on the type of the involved globin chain. Alpha Thalassaemia is developed when the alpha gene is affected and likewise, in beta-thalassemia, the globin chain is affected or the abnormal haemoglobin involved is beta-globin gen[3].
The incidence rate is about 4.4 of every 10000 live births globally and approximately about 5% of all population[2].
It has been estimated that the globally there are 9million carriers of Thalassaemia and Sickle cell anaemia become pregnant each year[4].
Clinically, Thalassemia is classified into three forms[3]:
- Thalassemia major: this is a severe form of anaemia where patients need continuous blood transfusions throughout their lives.
- Thalassemia intermedia: mild to moderate anaemia, patients occasionally need blood transfusions
- Thalassemia minor or trait: patients have mild symptoms and they usually don’t need blood transfusions
Sickle Cell Anaemia[edit | edit source]
References[edit | edit source]
- ↑ Cao A, Kan YW. The prevention of thalassemia. Cold Spring Harbor perspectives in medicine. 2013 Feb 1;3(2):a011775.
- ↑ 2.0 2.1 Kora A. The Physiotherapy Management of Thalassaemia and Sickle Cell Anaemia. Physioplus Course 2020
- ↑ 3.0 3.1 Aszhari FR, Rustam Z, Subroto F, Semendawai AS. Classification of thalassemia data using random forest algorithm. InJournal of Physics: Conference Series 2020 Mar 1 (Vol. 1490, No. 1, p. 012050). IOP Publishing.
- ↑ Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bulletin of the World Health Organization. 2008;86:480-7.
- ↑ What is Thalassemia? . Available from:https://www.youtube.com/watch?v=JxuupecxHO8[last accessed 30/09/2020]
