Muscle Repair
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Skeletal muscle repair requires the activation of satellite cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and extracellular matrix interactions. Immune, fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases
- Destruction phase : distinguished by rupture and necrosis of the myofibers, formation of a hematoma and an critical inflammatory reaction.
- Regeneration phase: phagocytosis of damaged tissue preceding myofibers regeneration, leading to satellite cell activation.
- Remodelling phase: maturation of regenerated myofibers with recovery of muscle functional capacity and fibrosis and scar tissue formation.[1]
Physiopedia has many great muscle repair related pages. Take a look at the following links to get a deeper understanding.
References[edit | edit source]
- ↑ Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)
