Telomere: Difference between revisions
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== Introduction == | == Introduction == | ||
Telomeres are repetitive deoxyribonucleic acid (DNA) sequences which cap the ends of chromosomes, protecting them from degradation, unlike the vital parts of our DNA they not contain information needed to make proteins. With every cell division the telomere shortens. When a critical telomere length (TL) is attained, cellular replication can no longer take place, and it becomes “senescent”. To counter this enter Telomerase. Telomerase is an enzyme found inside our cells (which may be related to the aging process) that adds short, repetitive “caps” to our DNA strands. The telomeres themselves in turn are protected by protein complexes called “shelterins”. These shelterins role is to regulate TA on the telomere and prevent telomerase overactivity to avoid excessive telomere elongation<ref>Haupt S, Niedrist T, Sourij H, Schwarzinger S, Moser O. The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints. Cells 2022, 11, 153. Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750279/ (accessed 23.7.2022)</ref>. | |||
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Revision as of 09:57, 23 July 2022
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton, Vidya Acharya and Tolulope Adeniji
Introduction[edit | edit source]
Telomeres are repetitive deoxyribonucleic acid (DNA) sequences which cap the ends of chromosomes, protecting them from degradation, unlike the vital parts of our DNA they not contain information needed to make proteins. With every cell division the telomere shortens. When a critical telomere length (TL) is attained, cellular replication can no longer take place, and it becomes “senescent”. To counter this enter Telomerase. Telomerase is an enzyme found inside our cells (which may be related to the aging process) that adds short, repetitive “caps” to our DNA strands. The telomeres themselves in turn are protected by protein complexes called “shelterins”. These shelterins role is to regulate TA on the telomere and prevent telomerase overactivity to avoid excessive telomere elongation[1].
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References[edit | edit source]
- ↑ Haupt S, Niedrist T, Sourij H, Schwarzinger S, Moser O. The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints. Cells 2022, 11, 153. Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750279/ (accessed 23.7.2022)
