Muscle Repair: Difference between revisions
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# Remodelling phase: maturation of regenerated myofibers with recovery of muscle functional capacity and fibrosis and [[Scar Management|scar]] tissue formation.<ref>Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)</ref> | # Remodelling phase: maturation of regenerated myofibers with recovery of muscle functional capacity and fibrosis and [[Scar Management|scar]] tissue formation.<ref>Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)</ref> | ||
[[File:Wound healing phases.png|center|thumb|1328x1328px|Wound healing phases]] | [[File:Wound healing phases.png|center|thumb|1328x1328px|Wound healing phases]] | ||
Skeletal muscle injuries can be caused by a multitude of events that may be direct trauma eg muscle lacerations and contusions or indirect eg strains and degenerative diseases. With minor muscle injuries regeneration is naturally repairs eg post quadriceps strain. On the other hand post severe trauma or degeneration, muscle healing is incomplete, often resulting in the fibrotic tissue with reduced functional capacity. | |||
Physiopedia has many great muscle repair related pages. Take a look at the following links to get a deeper understanding. | Physiopedia has many great muscle repair related pages. Take a look at the following links to get a deeper understanding. | ||
Revision as of 06:26, 1 July 2022
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Skeletal muscle repair requires the activation of satellite cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and extracellular matrix interactions. Immune, fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases
- Destruction phase : distinguished by rupture and necrosis of the myofibers, formation of a hematoma and an critical inflammatory reaction.
- Regeneration phase: phagocytosis of damaged tissue preceding myofibers regeneration, leading to satellite cell activation.
- Remodelling phase: maturation of regenerated myofibers with recovery of muscle functional capacity and fibrosis and scar tissue formation.[1]
Skeletal muscle injuries can be caused by a multitude of events that may be direct trauma eg muscle lacerations and contusions or indirect eg strains and degenerative diseases. With minor muscle injuries regeneration is naturally repairs eg post quadriceps strain. On the other hand post severe trauma or degeneration, muscle healing is incomplete, often resulting in the fibrotic tissue with reduced functional capacity.
Physiopedia has many great muscle repair related pages. Take a look at the following links to get a deeper understanding.
References[edit | edit source]
- ↑ Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)
