Muscle Repair: Difference between revisions
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== Introduction == | == Introduction == | ||
[[File:Myogenesis Schematic of satellite cell myogenesis and markers typical of each stage.jpg|right|frameless|489x489px]] | |||
[[Muscle Cells (Myocyte)|Skeletal muscle]] repair requires the activation of [[Satellite Cell|satellite]] cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and [[Extracellular Matrix|extracellular matrix]] interactions. [[Immune System|Immune]], fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases | [[Muscle Cells (Myocyte)|Skeletal muscle]] repair requires the activation of [[Satellite Cell|satellite]] cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and [[Extracellular Matrix|extracellular matrix]] interactions. [[Immune System|Immune]], fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases | ||
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# Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation. | # Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation. | ||
# Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and [[Scar Management|scar]] tissue formation.<ref>Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)</ref> | # Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and [[Scar Management|scar]] tissue formation.<ref>Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)</ref> | ||
Physiopedia has many great muscle repair related pages. Take a look at the following links to get a deeper understanding. | |||
[[Satellite Cell|Satellite Cells]] | * [[Satellite Cell|Satellite Cells]] | ||
* [[Soft Tissue Healing]] | |||
[[Soft Tissue Healing]] | * [[Muscle Injuries: Regeneration Strategies]] | ||
* [[Muscle Injuries]] | |||
[[Muscle Injuries: Regeneration Strategies]] | |||
[[Muscle Injuries]] | |||
== References == | == References == |
Revision as of 02:24, 1 July 2022
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Skeletal muscle repair requires the activation of satellite cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and extracellular matrix interactions. Immune, fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases
- Destruction phase with the initial inflammatory response
- Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation.
- Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and scar tissue formation.[1]
Physiopedia has many great muscle repair related pages. Take a look at the following links to get a deeper understanding.
References[edit | edit source]
- ↑ Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)