Effects of Exercise on Mild Alzheimer's Disease After the First Fall: A Case Study

Original Editor - Stacey Sanchez as part of the Queen's University Neuromotor Function Project
Top Contributors -

Abstract[edit | edit source]

This fictional case study presents an elderly patient with mild Alzheimer’s Disease (AD) who has experienced his first fall. Initial findings included poor balance, decreased strength, forgetfulness, reduced physical fitness and slow gait. The interventions consisted of an exercise-focused treatment program with an emphasis on functional tasks and balance exercises. Final outcomes included small improvements in balance, lower extremity strength, activities of daily living, and no noticeable decline in cognitive function. This case study focus on physical exercise is important as the typical aim for Alzheimer’s revolves around cognitive rehabilitation.

Introduction[edit | edit source]

Alzheimer’s disease (AD) is a chronic syndrome that leads to a significant deterioration of an individual’s cognitive and functional abilities[1]. It is a progressive disease that primarily affects individuals over the age of 65 years old. Older adults often live with a wide range of physical impairments as a part of the aging process, and those with AD must also deal with cognitive impairments that affect their ability to live independently.

There is currently no cure for AD, however, there are treatments that can slow the progression of the disease and improve quality of life for patients[1]. Education on this disease is important for physiotherapists because in Canada, there are an estimated 747,000 people diagnosed with AD and Dementia per year[1]. As the population of older adults increase, this number is projected to reach 1.4 million in 2031[1].

Physiotherapists play an important role in treating patients with AD since exercise has been shown to improve physical function, functional independence, and slow the progression of the disease[1]. This case study outlines the role that physiotherapy plays in the assessment, treatment, and follow-up of a patient with AD.

One of the challenges of dealing with the patient in this case is recognizing that his memory loss and the progressive nature of the disease will often lead to worsening of symptoms over time. The physiotherapist took steps to ensure the patient’s understanding of treatment measures and kept in communication with his wife to ensure proper delivery of the intervention at home.

Client Characteristics[edit | edit source]

Jude is a healthy 72 year old male. He is currently retired and lives at home with his wife. The patient is an active pole-walker and shuffleboard player. Past medical history includes Alzheimer’s Disease, a right knee replacement 10 years ago and controlled hypertension. Patient arrived at the Emergency Department following a recent fall at home and was discharged home with no injuries. Patient was referred to outpatient physiotherapy to address his balance deficits.

Examination Findings[edit | edit source]

Patient states that in the past three months, he and his wife have noticed his Alzheimer's Disease has been progressing quickly. Past diagnostic tests have ruled out other serious neurological conditions. He has been more forgetful lately, and has trouble remembering important dates, and frequently misplaces his keys. It has been difficult to go up stairs and he has been tripping more often. After his most recent fall, he reports no pain. He has been having trouble with walking and therefore has not been as active in the past month due to his fear of falling. Chores such as reaching for dishes and lifting items off the floor are now difficult and simple tasks such as dressing has been becoming increasingly difficult. He feels frustrated about his lack of physical activity and decrease in functional ability. His wife has noticed his mood has been fluctuating lately. He would like to return to pole-walking and be able to help his wife with chores.

Observation: Normal posture

ROM: Within normal limit in all joints

Sensation testing: Normal for light touch, pin prick and temperature.

Myotomes, Dermatomes, Reflexes: Normal

Manual Muscle Testing:

Muscle R L
Quadriceps 3+ 3
Hamstrings 3 3
Gastrocnemius 3- 3
Tibialis Anterior 3 3-

Grip Strength Hand Dynamometer

R: 37 kg L: 34 kg

(slightly weaker than normal for gender and age)

Gait Analysis: Decreased step length, decreased cadence, increased stance time bilaterally.

BERG Balance Scale: Scored 43/56 (At greater risk for fall)

  • Only able to complete 4 steps without aid with supervision (2/4)
  • Only able to lift leg independently and hold >/= 3 seconds (2/4)
  • Able to place feet together independently and stand 1 minute with supervision (3/4)
  • Able to take a small step independently and hold 30 seconds (2/4)
  • Unable to pick up and needs supervision while trying (1/4)
  • Can reach forward 5 cm (2/4)
  • Able to turn 360 degrees safely one side only 4 seconds or less (3/4)

Mini-Mental State Exam: 22/30 (Mild Impairment)

5x Sit to Stand: 13.5 seconds (At risk for fall)

Timed Up and Go: 15 seconds (At risk for fall)

Disability Assessment for Dementia: 68 (mild disability; impairment in completing ADLs and IADLs)

Clinical Impression[edit | edit source]

Patient presents with mild stage Alzheimer’s Disease. Patient shows decline in cognitive capacity as seen in difficulty planning tasks and increased forgetfulness. Patient shows signs of motor impairment (reduced balance, decreased lower extremity strength, slower gait) and is at risk for falls. Patient is a good candidate for physiotherapy and will benefit from balance exercises, aerobic and strength training, and cognitive rehabilitation.

Problem List:


  • Increased risk of falls - poor balance, poor visual spatial abilities
  • Decreased gait speed
  • Decreased upper and lower extremity strength


  • Difficulty planning complex tasks
  • Difficulty with functional memory

Intervention:[edit | edit source]

His goals included returning to physical activity (pole walking & shuffleboard), improving his balance to prevent future falls, walking up stairs safely and maintaining his ability to complete activities of daily living (ADLs) despite memory decline.

In the absence of a cure for Alzheimer’s Disease (AD), there are many interventions that can be used in an attempt to slow down the progression of the disease while maintaining independence and improve quality of life. Exercise therapies has shown to assist in the maintenance of both the physical and cognitive function of individuals with AD. Our intervention plan was aimed to improve his muscular strength and aerobic capacity, with a higher focus on balance training and performance of functional tasks that can translate to ADLs.

Due to the patient’s cognitive impairments, measures were taken to ensure the exercise program was concise and easy to follow. Handouts with step by step instructions and pictures were created for each exercise and reviewed with the patient and his wife.

Intervention Frequency Intensity Duration
Balance Exercises
  • Tandem Stance (can progress to Tandem Walk)
  • Weight Shift Side to Side
Daily As tolerated 1 set of 3 repetitions, 10 seconds hold each side. Progress as needed
Step Ups Daily As tolerated 1 set of 10 repetitions. Progress as needed
Sit to Stands Daily As tolerated 1 set of 10 repetitions. Progress as needed
Glute Bridges Daily As tolerated 1 set of 10 repetitions, hold for 3 seconds at the top. Progress as needed
Walking Daily Light Start at 20 min/day. Progress 5 mins per week or as tolerated
Pushing Exercises
  • Wall Push Ups
  • Chair Dips
3x/week Moderate 1 set of 10 repetitions. Progress as needed
Shoulder Elevation
  • Lifting objects (ex. canned foods, cups, dishes) from table to overhead
  • Resistance band Shoulder Press
3x/week Moderate 1 set of 10 repetitions. Progress as needed

Research Evidence for Management Plan:[edit | edit source]

Exercise Therapy

Balance Training

Falls are a major health concern in elderly populations. There is a strong correlation between fall occurrence and balance, which causes notable concern for people with AD as balance issues can appear early in the diagnosis[2]. Significant deficits in both static and dynamic balance can be noted, with specific difficulties in balance during turning, gait and dual task activities[3]. Both individual and group exercise sessions were found to provide benefit[3]. Specific exercises aimed at people with mild to moderate AD include tandem walks, with and without eye tracking, high side steps and weight shifts[4]. Video game interventions also exist that are likely to play a larger role for future generations that develop AD[5][6]. Specifically, using a Wii-fit intervention was shown to decrease fear of falls and increase Berg Balance Scale scores compared to a walking program[6]. An important criteria of balance programs and exercise programs in general is to be adequately challenging to show noticeable improvements[7]. Therefore, clinicians should continue this protocol even in patients with AD.

Strength Training

Strength Training promotes significant improvements in patients with AD[8]. Studies have shown the improvements were with respect to lower limb strength and balance. Resistance training with ADs not only increases muscle strength by 3-17%, but it also improves ambulatory abilities by increasing gait speed and enhances the individuals ability to perform ADLs[9]. By getting individuals with ADs to perform resistance exercises, we decrease the amount of muscle loss which decreases inactivity and the loss of functional ability. One study showed that with a 60 minute resistance training session 2x a week, balance and muscular endurance improved significantly[9]. Cardiorespiratory improvements were also noted in individuals who performed resistance training which would further promote an active lifestyle in individuals with AD[9].

Exercises that focus on functional tasks demonstrate a medium effect size on slowing the decline of cognitive ability, improving orientation, memory function and performance of functional task in AD patients[10]. These strategies focus on learning compensatory techniques that can be applied to activities of daily living[11].

Aerobic Training

Aerobic Training has been shown to improve an AD’s patients ability to independently perform activities of daily living (ADLs) by improving their overall functional capacity[12]. Studies have also shown that improvements in cardiorespiratory fitness were related to better memory performances[13]. Although currently still unsure of the optimal modality and dosage of aerobic exercise, there is evidence that shows cognitive and physical improvements can occur to help delay the progression of ADs while allowing the patient to live an active life.

A Reducing Disability in Alzheimer Disease (RDAD) program was designed to reduce impairments in independence and behaviour in AD populations. The RDAD has an exercise component that consists of 30min/day of aerobic activities, strength training, balance, and flexibility training. A study that compared the RDAD to normal routine care showed improved physical functioning after 3 months in RDAD patients that exercised at least 60min/wk. This effect lasted 2 years after the study. These patients also were less institutionalized[14].

Outcome[edit | edit source]

At 6 weeks post-intervention, the patient showed slight improvements in balance, strength, and reports improvements in performing ADLs at home. He is able to walk more regularly. He showed no decline in cognitive and disability impairments since the initial assessment.

Manual Muscle Testing:

Muscle R L
Quadriceps 4- 4-
Hamstrings 3+ 3+
Gastrocnemius 3+ 3+
Tibialis Anterior 4- 3+

Grip Strength Hand Dynamometer

R: 40 kg L: 37 kg

(improvement, slightly weaker than normal for age and gender range)

BERG Balance Scale: - Scored 48/56 (Improvement, but still at slight risk for fall)

  • Able to stand independently and complete 8 steps in >20 seconds (3/4)
  • Only able to lift leg independently and hold >/= 3 seconds (2/4)
  • Able to place feet together independently and stand 1 minute with supervision (3/4)
  • Able to place foot ahead independently and hold 30 seconds (3/4)
  • Unable to pick up but reaches 2-5 cm(1-2 inches) from slipper and keeps balance independently (2/4)
  • Can reach forward 12 cm (3/4)
  • Able to turn 360 degrees safely one side only 4 seconds or less (3/4)

Mini-Mental State Exam: 22/30 (Mild Impairment)

5x Sit to Stand: 11 seconds (No longer a fall risk)

Timed Up and Go: 12.35 seconds (Improved score, but still at risk for falls)

Disability Assessment for Dementia: 70 (mild disability; impairment in completing ADLs and IADLs)


  • Refer to Occupational Therapy to address cognitive impairments and to work towards completing ADLs and IADLs independently.
  • Refer to Geriatrician to address and follow up with the progression of the disease as well as normal aging process.
  • Refer to community resources (e.g. exercise programs, Alzheimer’s support group)

Discussion[edit | edit source]

The present case study demonstrates a typical presentation of a patient with mild Alzheimer’s Disease (AD). Signs include memory impairment, personality changes, balance deficiencies, and lost of independence in performing ADLs as the disease progresses. To address these concerns, we created a treatment that focused on an exercise intervention for mild AD. Research on general strength and aerobic exercise programs have demonstrated improvements in strength, balance, memory function and depression. Improvements specific to ADL performance can be optimized by using exercises that incorporate functional task as these are more meaningful. These exercises can also address balance, which with improvement through exercises such as weight shifting and tandem stance, are shown to decrease fall risk.

While these studies have been specific to AD populations, their findings can be implicated to other neurodegenerative conditions with cognitive impairments such as Vascular Dementia, Dementia with Lewy Bodies, Parkinson's, and Stroke. An exercise-focused rehabilitation program may be an effective method to address both physical deficits and cognitive decline. Beginning an exercise program early after symptom-development and diagnosis may bestow a slowing of future regression.

Self-Study Questions[edit | edit source]

Aerobic training has been to shown to improve the following except:

A) Cardiorespiratory health

B) Depression

C) Cognitive Function

D) Flexibility

Which of the following is least likely to be a early symptom for Alzheimer?

A) Decreased BERG score

B) Limited Range of Motion

C) Personality Changes

D) Misplacing items

Which of following types outcome measures would be the least relevant to use with patients with Alzheimer's?

A) Balance


C) Depression

D) Fatigue

References[edit | edit source]

  1. 1.0 1.1 1.2 1.3 1.4 What Is Alzheimer's? [Internet]. Alzheimer's Disease and Dementia. [cited 2019May9]. Available from: https://www.alz.org/alzheimers-dementia/what-is-alzheimers
  2. Pettersson AF, Engardt M, Wahlund LO. Activity level and balance in subjects with mild Alzheimer’s disease.Dement Geriatr Cogn Disord [Internet]. 2002 [cited 2019 May 8];13(4):213-6. Available from: https://www.karger.com/Article/Abstract/57699
  3. 3.0 3.1 Ries JD, Hutson J, Maralit LA, Brown MB. Group balance training specifically designed for individuals with Alzheimer disease: impact on berg balance scale, timed up and go, gait speed, and mini-mental status examination. J Geriatr Phys Ther [Internet]. 2015 Oct 1 [cited 2019 May 8];38(4):183-93. Available from: https://www.ingentaconnect.com/content/wk/jpt/2015/00000038/00000004/art00004
  4. Borges-Machado F, Ribeiro Ó, Sampaio A, Marques-Aleixo I, Meireles J, Carvalho J. Feasibility and Impact of a Multicomponent Exercise Intervention in Patients With Alzheimer’s Disease: A Pilot Study. Am J Alzheimers Dis Other Demen [Internet]. 2019 Mar [cited 2019 May 8];34(2):95-103. Available from: https://journals.sagepub.com/doi/full/10.1177/1533317518813555
  5. Klages K, Zecevic A, Orange JB, Hobson S. Potential of Snoezelen room multisensory stimulation to improve balance in individuals with dementia: a feasibility randomized controlled trial. Clin Rehabil [Internet]. 2011 July [cited 2019 May 8];25(7):607-16.Available from: https://journals.sagepub.com/doi/abs/10.1177/0269215510394221
  6. 6.0 6.1 Padala KP, Padala PR, Lensing SY, Dennis RA, Bopp MM, Roberson PK, Sullivan DH. Home-based exercise program improves balance and fear of falling in community-dwelling older adults with mild Alzheimer’s disease: a pilot study. J Alzheimers Dis[Internet]. 2017 Jan 1 [cited 2019 May 8];59(2):565-74. Available from: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad170120
  7. Sherrington C, Whitney JC, Lord SR, Herbert RD, Cumming RG, Close JC. Effective exercise for the prevention of falls: a systematic review and meta‐analysis. J Am Geriatr Soc [Internet]. 2008 Dec [cited 2019 May 8];56(12):2234-43. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1532-5415.2008.02014.x
  8. Garuffi M, Costa JLR, Hernandez SSS, Vital TM, Stein AM, Gomes dos Santos J, et al. Effects of resistance training on the performance of activities of daily living in patients with Alzheimer's disease. Geriatr Gerontol Int [Internet].2012 [cited 2019 May 8];3(2). Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1447-0594.2012.00899.x
  9. 9.0 9.1 9.2 Ahn N, Kim K. Effects of an elastic band resistance exercise program on lower extremity muscle strength and gait ability in patients with Alzheimer’s disease. J Phys Ther Sci [Internet].2015 [cited 2019 May 8];27(6):1953-5. Available from: https://www.jstage.jst.go.jp/article/jpts/27/6/27_jpts-2015-025/_article/-char/ja/
  10. Sitzer DI, Twamley EW, Jeste DV. Cognitive training in Alzheimer's disease: a meta‐analysis of the literature. Acta Psychiatr Scand [Internet]. 2006 Aug [cited 2019 May 9];114(2):75-90. Available from:https://www.ncbi.nlm.nih.gov/pubmed/16836595/
  11. Choi J, Twamley EW. Cognitive rehabilitation therapies for Alzheimer’s disease: a review of methods to improve treatment engagement and self-efficacy. Neuropsychol Rev [Internet]. 2013 Mar 1 [Cited 2019 May 8];23(1):48-62.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596462
  12. Santana-Sosa E, Barriopedro MI, López-Mojares LM, Pérez M, Lucia A. Exercise training is beneficial for Alzheimer's patients. Int J Sports Med. 2008 Oct;29(10):845-50. Available from: https://www.thieme-connect.com/products/ejournals/html/10.1055/s-2008-1038432
  13. Morris JK, Vidoni ED, Johnson DK, Van Sciver A, Mahnken JD, Honea RA, Wilkins HM, Brooks WM, Billinger SA, Swerdlow RH, Burns JM. Aerobic exercise for Alzheimer's disease: a randomized controlled pilot trial. PloS one [Internet]. 2017 Feb 10 [cited 2019 May 8];12(2):e0170547.Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302785/
  14. Teri L, Gibbons LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, Kukull WA, LaCroix AZ, McCormick W, Larson EB. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. Jama [Internet]. 2003 Oct 15 [cited 2019 May 8];290(15):2015-22.Available from: https://jamanetwork.com/journals/jama/fullarticle/197483