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The principle of mirror therapy (MT) is the use of a mirror to create a reflective illusion of an affected limb in order to trick the brain into thinking movement has occurred without pain. It involves placing the affected limb behind a mirror, which is sited so the reflection of the opposing limb appears in place of the hidden limb . A Mirror box is a device which allows the clinician to easily create this illusion. It' is a box with one mirror in the center where on each side of it, the hands are placed in a manner that the affected limb is kept covered always and the unaffected limb is kept on the other side whose reflection can be seen on the mirror.
Mirror therapy was invented by Vilayanur S. Ramachandran to help alleviate the Phantom limb Pain, in which patients feel they still have a pain in the limb even after having it amputated.
Ramachandran and Rogers-Ramachandran  first devised the technique in an attempt to help those with phantom limb pain resolve what they termed a ‘learned paralysis’ of the painful phantom limb. The visual feedback, from viewing the reflection of the intact limb in place of the phantom limb, made it possible for the patient to perceive movement in the phantom limb. Their hypothesis was that every time the patient attempted to move the paralyzed limb, they received sensory feedback (through vision and Proprioception) that the limb did not move. This feedback stamped itself into the brain circuitry through a process of Hebbian learning, so that, even when the limb was no longer present, the brain had learned that the limb (and subsequent phantom) was paralyzed. To retrain the brain, and thereby eliminate the learned paralysis, Ramachandran and Rogers-Ramachandran created the mirror box.
The patient places the good limb into one side, and the stump into the other. The patient then looks into the mirror on the side with good limb and makes "mirror symmetric" movements, as a symphony conductor might, or as we do when we clap our hands. Because the subject is seeing the reflected image of the good hand moving, it appears as if the phantom limb is also moving. Through the use of this artificial visual feedback it becomes possible for the patient to "move" the phan tom limb, and to unclench it from potentially painful positions.
Principle of Mirror Therapy
- This approach exploits the brain’s preference to prioritise visual feedback over somatosensory/proprioceptive feedback concerning limb position. In conditions such as phantom limb pain (PLP), stroke, or Chronic Regional Pain Syndrome Type 1 (CRPS1) where neuropathic processes cause issues with pain, related or unrelated to movement, this approach is thought to offer potential relief .
- MT has been shown to increase cortical and spinal motor excitability, possibly through the effect on the mirror neuron system . Mirror Neurons accounts for about 20% of all the neurons present in a human brain. These mirror neurons are responsible for laterality reconstruction i.e., ability to differentiate between the left and the right side. When using the Mirror box, these mirror neurons gets activated and helps in the recovery of affected parts.This system is thought to use the observation of movement to stimulate the motor processes which would be involved in that movement. Similarities have been drawn with motor imagery where by the individual will mentally imagine movements rather than observing the reflection of a movement in a mirror . It is thought that the brains natural inclination to prioritise visual feedback over all others would make MT a more powerful tool, however research evidence is currently lacking in support of this hypothesis  . It is to be noted that the major difference in the neuronal reorganisation while using a mirror box is that the ipsilateral hemisphere's neurons gives connection to the same side affected limbs rather than the conventional therapies which targets the neuronal reorganization of the contra-lateral hemisphere.  
Evidence on effectiveness
Most of the evidence since the early work has come from case studies and anecdotal data.
- Chan et al (2007)  allocated 22 patients with Phantom Limb Pain (PLP) into a mirror therapy group, mental imagery group and a covered mirror group (control) . They reported that all patients in the mirror therapy group experienced reduced PLP. This was not the case in the other two groups. The study did not control potential biases and its methodology was not described in detail, so weakening the power of its findings.
- A more robust trial investigated two groups of subjects suffering with PLP . A mirror group were compared to a covered mirror group, however, there were no statistically significant reductions in PLP between groups.
- In 2011 a large scale review of the literature on mirror therapy by Rothgangel  summarized the current research as follows:"For stroke there is a moderate quality of evidence that MT as an additional intervention improves recovery of arm function, and a low quality of evidence regarding lower limb function and pain after stroke. The quality of evidence in patients with complex regional pain syndrome and phantom limb pain is also low. Firm conclusions could not be drawn. Little is known about which patients are likely to benefit most from MT, and how MT should preferably be applied. Future studies with clear descriptions of intervention protocols should focus on standardised outcome measures and systematically register adverse effects".
- A further review  of current approaches in the treatment of PLP concluded that the benefits of mirror therapy appear to be limited to patients who suffer from cramping and muscular-type phantom pain . They noted that despite the findings of one RCT, there was no systematic evidence to support the use of this modality and even some suggestion it could be counterproductive. However, this may be due to study design, choice and size of sample and application of the modality .
- Diers et al (2010)  noted that applying MT as part of a sequence of modalities appeared to produce positive results against applying it in isolation . In an RCT, patients with CRPS1 and PLP showed decreases in pain, and improved function both immediately post treatment and at a 6 month follow-up when using mirror training as part of a sequence of modalities known as Graded Motor Imagery (GMI). Mirrored imagery alone did not, however, activate cortical processes in patients with phantom limb pain. The authors concluded that further research was required to establish the cortical processes underlying MT and motor imagery in order to guide the optimal method of application for these modalities .
These findings appeared to support earlier suggestions that whilst mirrored movements may expose the cortex to sensory and motor input, the therapeutic effect is magnified if cortical networks were gradually activated using limb recognition, motor imagery and finally mirrored movement  .
MT in Stroke
Mirror therapy (MT) has been employed with some success in treating stroke patients. Clinical studies that have combined mirror therapy with conventional rehabilitation have achieved the most positive outcomes. However there is no clear consensus as to its effectiveness. In a recent survey of the published research Rothgangel concluded that "In stroke patients, we found a moderate quality of evidence that MT as an additional therapy improves recovery of arm function after stroke. The quality of evidence regarding the effects of MT on the recovery of lower limb functions is still low, with only one study reporting effects. In patients with CRPS and PLP, the quality of evidence is also low."  A recent Cochrane Review summarised the effectiveness of mirror therapy for improving motor function, activities of daily living, pain and visuospatial neglect in patients after stroke. 14 studies with a total of 567 participants that compared mirror therapy with other interventions were compared. At the end of treatment, mirror therapy improved movement of the affected limb and the ability to carry out daily activities, it reduced pain after stroke, but only in patients with a complex regional pain syndrome and the beneficial effects on movement were maintained for six months, but not in all study groups.
MT IN CPRS
Working with patients with different complex regional pain syndromes can be challenging. Pharmacological therapies are often associated with variety of side effects. Mind-body modalities are thought to play a role; however, the lack of clear consensus and large body of clinical experience makes it hard to provide good evidence-based recommendation to most of our chronic pain patients. Current evidence supports the use of Mirror Box Therapy. 
Graded Motor Imagery
Graded Motor Imagery (GMI) is a rehabilitation process used to treat pain and movement problems related to altered nervous systems by exercising the brain in measured and monitored steps that gradually expose the cortex to sensory and motor input and so enable cortical networks to open up in response.
GMI involves 3 steps as follows:
- Left/right discrimination training
- Motor imagery exercises
- Mirror therapy
These techniques are delivered sequentially but require a flexible approach from the patient and clinician to move forwards, backwards and sideways in the treatment process to suit the individual. 
Clinicians wishing to investigate GMI further can find resources at Www.noigroup.com.
MT is a non-pharmacological and alternative treatment strategy that has been proposed as a means of managing PLP. It is a neuro-rehabilitation technique designed to remodulate cortical mechanisms. With this technique, patients perform movements using the unaffected limb whilst watching its mirror reflection superimposed over the (unseen) affected limb. This creates a visual illusion and provides positive feedback to the motor cortex that movement of the affected limb has occurred. The approach is thought to offer potential relief through the visual dominance upon motor and sensory processes.
Considering the importance of PLP and its management, MT offers clinicians an easy-to-use and low-cost adjuvant therapeutic technique. However, its effectiveness as a stand alone modality largely arises from low quality evidence. Instead, there is a greater weight of evidence in favour of its use as a combined or sequential therapy, such as Graded Motor Imagery .
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Recent Related Research (from Pubmed)
- Observation of limb movements reduces phantom limb pain in bilateral amputees.
- Agency over a phantom limb and electromyographic activity on the stump depend on visuomotor synchrony: a case study.
- Manipulation of visual biofeedback during gait with a time delayed adaptive Virtual Mirror Box.
- Treatment of phantom limb pain (PLP) based on augmented reality and gaming controlled by myoelectric pattern recognition: a case study of a chronic PLP patient.
- An augmented reality home-training system based on the mirror training and imagery approach.
- A realistic implementation of ultrasound imaging as a human-machine interface for upper-limb amputees.
- Inter-individual difference in the effect of mirror reflection-induced visual feedback on phantom limb awareness in forearm amputees.
- Mirror therapy as an alternative treatment for phantom limb pain: a short literature review.
- Postamputation pain: epidemiology, mechanisms, and treatment.
- Mirror therapy for phantom limb pain.
- ↑ 1.0 1.1 1.2 Moseley, GL; Gallace, A; Spence, C (2008), "Is mirror therapy all it is cracked up to be? Current evidence and future directions", PAIN 138 (1): 7–10, doi:10.1016/j.pain.2008.06.026, PMID 18621484
- ↑ Ramachandran, V. S.; Rogers-Ramachandran, D. C. (1996), "Synaesthesia in phantom limbs induced with mirrors", Proceedings of the Royal Society of London (263(1369)): 377–386, doi:10.1098/rspb.1996.0058, PMID 8637922
- ↑ Ramachandran, V. S.; Rogers-Ramachandran, D. C.; Cobb, S. (1995), "Touching the phantom", Nature (377): 489–490
- ↑ 4.0 4.1 4.2 4.3 Diers, M; Christmann, C; Koeppe, C; Ruf, M; Flor, H (2010), "Mirrored, imagined, and executed movements differentially activate sensorimotor cortex in amputees with and without phantom limb pain", PAIN 149 (2): 296–304, doi:10.1016/j.pain.2010.02.020, PMID 20359825
- ↑ Vittorio Gallese and Alvin Goldman, Mirror neurons and the simulation theory of mind-reading, Trends in Cognitive Sciences – Vol. 2, No. 12, December 1998, 1364-6613/98/$
- ↑ Ashu Bhasin, MV Padma Srivastava, Senthil S Kumaran, Rohit Bhatia, Sujata Mohanty, Neural interface of mirror therapy in chronic stroke patients: A functional magnetic resonance imaging study, 2012, Neurology India, 60, 6, 570-576.
- ↑ Chan B, Witt R, Charrow A, et al. Mirror therapy for phantom limb pain. N Engl J Med 2007;357:2206–7.
- ↑ Brodie E, Whyte A, Niven C. Analgesia through the looking glass? A randomized controlled trial investigating the effect of viewing a ‘virtual’ limb upon phantom limb pain, sensation and movement. Eur J Pain 2007;11:428–36.
- ↑ 9.0 9.1 Rothgangel,S, Braun,S, Beurskens,A, Seitz,R, Wade,D, The clinical aspects of mirror therapy in rehabilitation: a systematic review of the literature, Journal of Rehabilitation Research, 34:1-13,2011
- ↑ Giummarra, Melita; Moseley, Lorimer (2011), "Phantom limb pain and bodily awareness:current concepts and future directions", Current Opinions in Anesthesiology 24: 524–531
- ↑ Moseley GL. Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb? A randomised clinical trial. Pain 2005;114:54–61.
- ↑ Moseley GL. Graded motor imagery for pathologic pain: a randomized controlled trial. Neurology 2006; 67:2129–34.
- ↑ /Subeyaz,S, Yavuzer,G, Sezer,N, Koseoglu,F, Mirror Therapy Enhances Lower-Extemity Motor Recovery and Motor Functioning After Stroke: A Randomized Controlled Trial, Archives Physical Medicine and Rehabilitation, Vol 88, May 2007
- ↑ Rothgangel,S, Braun,S, Beurskens,A, Seitz,R, Wade,D, The clinical aspects of mirror therapy in rehabilitation: a systematic review of the literature, Journal of Rehabilitation Research, 34:1-13,2011
- ↑ Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C. Mirror therapy for improving motor function after stroke. The Cochrane Library, 14 March 2012.
- ↑ Lamont K, Chin M, Kogan M., Mirror box therapy: seeing is believing. Explore (NY). 2011 Nov-Dec;7(6):369-72.
- ↑ Bowering KJ, O'Connell NE, Tabor A, Catley MJ, Leake HB, Moseley GL, Stanton TR., The effects of graded motor imagery and its components on chronic pain: a systematic review and meta-analysis. J Pain. 2013 Jan;14(1):3-13. doi: 10.1016/j.jpain.2012.09.007. Epub 2012 Nov 15.
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