Psychedelics and Brain Neuroplasticity
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton, Vidya Acharya and Kim Jackson
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Introduction[edit | edit source]
Psychedelics are psychoactive substances which can alter the way the brain functions and are belong to the ‘hallucinogens' family. More precisely are a type of serotonin (a neurotransmitter) receptor agonist that can lead to intense alterations in perception, cognition and mood[1]. Psychedelics are recently being identified as a possible option to treat a wide range of brain disorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder and possibly even prove to have therapeutic potential for treatment of neurodegenerative disorders.[2]
Action[edit | edit source]
Psychedelics seem to suppress the default network. One likely outcome is the relaxing of the separation of our senses, memories, thoughts and emotions, so they can influence each other more readily. The default mode network (DMN) relies on low-frequency oscillations of about one fluctuation per second, and is uses a small amount of energy being largely. This DMN deactivates when we direct out attention to a task/goal.at rest.
Psychedelics seemingly have the power to suppress the DMN and make asvailable many more pathways between regions of the brain that don't usually "talk" much together, unfastening the separation of our eg. emotions, memories, and senses senses. Recent finding show psychedelics induce molecular and cellular adaptations connected to neuroplasticity, which can then be harnessed for treatment in eg many mental and possible brain injury/degenerative disorders.[3]
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References[edit | edit source]
- ↑ Kwan AC, Olson DE, Preller KH, Roth BL. The neural basis of psychedelic action. Nature Neuroscience. 2022 Nov;25(11):1407-19.Available:https://www.nature.com/articles/s41593-022-01177-4 (accessed 3.10.2023)
- ↑ Saeger HN, Olson DE. Psychedelic‐inspired approaches for treating neurodegenerative disorders. Journal of Neurochemistry. 2022 Jul;162(1):109-27.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126991/ (accessed 3.10.2023)
- ↑ De Vos CM, Mason NL, Kuypers KP. Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics. Frontiers in psychiatry. 2021 Sep 10;12:724606.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461007/ (accessed 3.10.2023)
