Persistent Genital Arousal Disorder (PGAD)
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Introduction[edit | edit source]
Persistent genital arousal disorder (PGAD), restless genital syndrome (ReGS), or genitopelvic dysesthesia (GD) a rare disorder defined as persistatant, unpleasant , distressing sensation of unwanted arousal of genetalia, happens in the absence of any arousal or sexual stimulus, dose not resolve by orgasm or masturbation, may last for hours or days, and usually has a negative impact on individual's life. Symptoms may be triggered by sexual cues, non-sexual cues, or it may be idiopathic. Persistent genital arousal disorder (PGAD) was described for the first time in 2001 by Sandra Leiblum and Sharon Nathan[1].
Mechanism of Injury / Pathological Process[edit | edit source]
As it was described for first time 20 years ago and it difficult to know its prevalence there is limited studies about PGAD that are individual case studies till now there is not RCT or SR studies about PGAD how to diagnose, assess, or treat.
There are different hypotheses for causes of PGAD that may be multifacorial; vascular factors, central and peripheral nervous system factors, pharmacological factors, psychosocial factors, dietary, or even idiopathetic factors.
Pharmacological factors, it was reported in a few case report studies that drugs that contain serotonergic such as antidepressant medication (SSRIs /SNRIs) may induce or worsen PGAD symptoms [2]even at initiation or withdrawal of drug, however, there were cases in which there was a fundamental improvement of PGAD symptoms anticonvulsant or SNRI[3].
Clinical Presentation[edit | edit source]
Pain or discomfort in the genetalia
Tingling around clitoris.
Diagnostic Procedures[edit | edit source]
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Outcome Measures[edit | edit source]
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Management / Interventions
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Differential Diagnosis
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Resources
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References[edit | edit source]
- ↑ Jackowich RA, Pukall CF. Persistent genital arousal disorder: a biopsychosocial framework. Current Sexual Health Reports. 2020 Sep;12:127-35.
- ↑ Leiblum SR, Goldmeier D. Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal. Journal of Sex & Marital Therapy. 2008 Feb 21;34(2):150-9.
- ↑ Kruger TH, Schippert C, Meyer B. The pharmacotherapy of persistent genital arousal disorder. Current Sexual Health Reports. 2020 Mar;12:34-9.
