Palindromic Rheumatism
Original Editor - Pacifique Dusabeyezu
Top Contributors - Pacifique Dusabeyezu, Habibu Salisu Badamasi and Kim Jackson
Introduction[edit | edit source]
Palindromic rheumatism (PR) is an intermittent disease characterized by recurring, self-resolving attacks of inflammation in the articular and periarticular tissues. These attacks usually affect only one joint and can last from a few hours to a few days. Interestingly, during the attacks, patients do not experience any symptoms. The joints most commonly involved in these attacks are the knees, wrists, metacarpophalangeal joints, and proximal interphalangeal (PIP) joints.[1][2]
The key distinguishing feature between PR and Rheumatoid arthritis (RA) is the relapsing-remitting clinical presentation of PR, as opposed to the generally persistent joint involvement in RA that does not remit unless treated.[2]
Etiology[edit | edit source]
The exact cause of Palindromic Rheumatism (PR) is still unknown. However, research indicates that PR is linked to the development of autoimmune rheumatic diseases, particularly rheumatoid arthritis (RA). Studies have shown that after a varying follow-up period, approximately 15% to 66% of patients with PR went on to develop RA.
Several factors predict the progression of psoriatic arthritis (PR) to rheumatoid arthritis (RA), including genetic background, ultrasonographic findings of synovitis, the presence of anti-cyclic citrullinated peptide antibodies (ACPA), positive rheumatoid factor, and hand involvement. Conversely, some genetic backgrounds, like HLA-DRB1, may increase susceptibility to Palindromic Rheumatism(PR) but not RA, indicating that PR is distinct from RA.
Resources[edit | edit source]
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References[edit | edit source]
- ↑ Kavandi H, Hashemi SZ, Khalesi E, Khabbazi A. Treatment of palindromic rheumatism: A systematic review. International Journal of Clinical Practice. 2021 Sep 20;75(11).
- ↑ 2.0 2.1 Corradini D, Di Matteo A, Emery P, Mankia K. How should we treat palindromic rheumatism? A systematic literature review. Semin Arthritis Rheum [Internet]. 2021;51(1):266–77.
