Frontotemporal Dementia: Difference between revisions
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== Description == | == Description == | ||
The term “Pick’s Disease” (PiD) was named after Arnold Pick for his initial description of focal gross atrophy of the frontotemporal lobes in a patient with progressive language and behavioral disturbances <ref>Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM. Deep clinical and neuropathological phenotyping of Pick disease. Annals of neurology. 2016 Feb;79(2):272-87.</ref>. Pick’s disease is a rare neurodegenerative disorder, estimated to be 10 times less frequent than [[Alzheimer's Disease|Alzheimer’s disease,]] even in regions with high prevalence. It was first clinically described by Pick in 1892, a German neurologist, in a woman with lobar brain atrophy who suffered from pre-senile dementia with dysphasia <ref>Dickson DW. Pick's disease: a modern approach. Brain pathology. 1998 Apr;8(2):339-54.</ref>. Current knowledge indicates that PiD is a member of a group of heterogeneous neurodegenerative disorders with similar or related histopathologic and clinical features known as frontotemporal lobal degeneration or dementia (FTD) <ref>Hu W, Luo JJ. Research Advances in Pick’s Disease: A New Biomarker Candidate. J Neurol Neurophysiol. 2013;4:e112.</ref>.[[File:Pick's disease.png|center|674x674px]] | The term “Pick’s Disease” (PiD) was named after Arnold Pick for his initial description of focal gross atrophy of the frontotemporal lobes in a patient with progressive language and behavioral disturbances <ref>Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM. Deep clinical and neuropathological phenotyping of Pick disease. Annals of neurology. 2016 Feb;79(2):272-87.</ref>. Pick’s disease is a rare [[Neurodegenerative Disease|neurodegenerative]] disorder, estimated to be 10 times less frequent than [[Alzheimer's Disease|Alzheimer’s disease,]] even in regions with high prevalence. It was first clinically described by Pick in 1892, a German neurologist, in a woman with lobar brain atrophy who suffered from pre-senile dementia with dysphasia <ref>Dickson DW. Pick's disease: a modern approach. Brain pathology. 1998 Apr;8(2):339-54.</ref>. Current knowledge indicates that PiD is a member of a group of heterogeneous neurodegenerative disorders with similar or related histopathologic and clinical features known as frontotemporal lobal degeneration or dementia (FTD) <ref>Hu W, Luo JJ. Research Advances in Pick’s Disease: A New Biomarker Candidate. J Neurol Neurophysiol. 2013;4:e112.</ref>.[[File:Pick's disease.png|center|674x674px]] | ||
== Causes == | == Causes == | ||
Pick’s disease, along with other FTDs, is caused by abnormal amounts or types of nerve cell proteins, called tau. These proteins are found in all of our nerve cells. They are usually stored in Pick bodies or Pick cells causing the brain tissue to shrink and leading to [[dementia]] <ref>Pick Disease of the Brain: Causes, Symptoms, and Diagnosis. Available from: <nowiki>https://www.healthline.com/health/picks-disease#symptoms</nowiki> (Accessed, 01/08/2021).</ref>. | Pick’s disease, along with other FTDs, is caused by abnormal amounts or types of nerve cell proteins, called tau. These proteins are found in all of our nerve cells. They are usually stored in Pick bodies or Pick cells causing the brain tissue to shrink and leading to [[dementia]] <ref name=":0">Pick Disease of the Brain: Causes, Symptoms, and Diagnosis. Available from: <nowiki>https://www.healthline.com/health/picks-disease#symptoms</nowiki> (Accessed, 01/08/2021).</ref>. | ||
== '''Symptoms''' == | == '''Symptoms''' == | ||
Pick's Disease is a progressive dementia charaterized by prorgressive changes leading to impairment of intellect, memory and language. | Pick's Disease is a progressive dementia charaterized by prorgressive changes leading to impairment of intellect, memory and language <ref name=":0" />. | ||
== References == | == References == | ||
Revision as of 22:26, 2 August 2021
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Description[edit | edit source]
The term “Pick’s Disease” (PiD) was named after Arnold Pick for his initial description of focal gross atrophy of the frontotemporal lobes in a patient with progressive language and behavioral disturbances [1]. Pick’s disease is a rare neurodegenerative disorder, estimated to be 10 times less frequent than Alzheimer’s disease, even in regions with high prevalence. It was first clinically described by Pick in 1892, a German neurologist, in a woman with lobar brain atrophy who suffered from pre-senile dementia with dysphasia [2]. Current knowledge indicates that PiD is a member of a group of heterogeneous neurodegenerative disorders with similar or related histopathologic and clinical features known as frontotemporal lobal degeneration or dementia (FTD) [3].
Causes[edit | edit source]
Pick’s disease, along with other FTDs, is caused by abnormal amounts or types of nerve cell proteins, called tau. These proteins are found in all of our nerve cells. They are usually stored in Pick bodies or Pick cells causing the brain tissue to shrink and leading to dementia [4].
Symptoms[edit | edit source]
Pick's Disease is a progressive dementia charaterized by prorgressive changes leading to impairment of intellect, memory and language [4].
References[edit | edit source]
- ↑ Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM. Deep clinical and neuropathological phenotyping of Pick disease. Annals of neurology. 2016 Feb;79(2):272-87.
- ↑ Dickson DW. Pick's disease: a modern approach. Brain pathology. 1998 Apr;8(2):339-54.
- ↑ Hu W, Luo JJ. Research Advances in Pick’s Disease: A New Biomarker Candidate. J Neurol Neurophysiol. 2013;4:e112.
- ↑ 4.0 4.1 Pick Disease of the Brain: Causes, Symptoms, and Diagnosis. Available from: https://www.healthline.com/health/picks-disease#symptoms (Accessed, 01/08/2021).
