Wallerian Degeneration: Difference between revisions
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== Clinically Relevant Anatomy == | == Clinically Relevant Anatomy == | ||
Wallerian degeneration is an active process of retrograde degeneration of an axon that is | Wallerian degeneration is an active process of retrograde degeneration of an axon that is a result of a nerve lesion. | ||
Usually the rate of degeneration is slower in the Central Nervous System than peripheral Nervoius system due ggto the clearance of mylein sheets.<br> | |||
== Mechanism of Injury / Pathological Process == | == Mechanism of Injury / Pathological Process == | ||
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* regeneration | * regeneration | ||
* | * | ||
<br> | <br>https://www.youtube.com/watch?v=EcX7DWjC-7o | ||
== Clinical Presentation == | == Clinical Presentation == | ||
Most patients have presentations of nerve damage as the nerves are degenerated. | |||
These presentations may include[[Nerve Injury Rehabilitation|[2]]] | |||
* Paralysis of associated structures to denervated nerves | |||
* Gradual onset of numbness, prickling, or tingling in your feet or hands, which can spread upward into your legs and arms | |||
* Sharp, jabbing, throbbing, freezing, or burning pain | |||
* Extreme sensitivity to touch | |||
* Lack of coordination and falling | |||
* Muscle weakness or paralysis if motor nerves are affected | |||
* Neuromatous or causalgia pain | |||
== Diagnostic ProceduresElectromyography == | |||
* Nerve Conduction Studies | |||
** Pain assessment | |||
** Sensation deficit and skin condition | |||
** Muscle strength/loss | |||
** Functional deficits | |||
** Balance deficits | |||
** Joint stiffness | |||
** Emotional stress Outcome M <br> | |||
== Outcome Measures == | == Outcome Measures == | ||
Depends on various criteria but could include: | |||
* [[Muscle Strength|Oxford scale]] | |||
* [[Romberg Test|Romberg]] or [[Berg Balance Scale|Berg]] balance test | |||
* [[Visual Analogue Scale|Visual analogue scale]] | |||
* [[Short-form McGill Pain Questionnaire|Short form McGill]] pain questionnaire | |||
* [[Nine-Hole Peg Test|Nine-hole peg test]] | |||
(see [[Outcome Measures|Outcome Measures Database]]) | |||
== Management / Interventions == | == Management / Interventions == | ||
Cryotherapy<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315870/</ref>, <br> | |||
== Differential Diagnosis == | == Differential Diagnosis == |
Revision as of 22:28, 2 March 2021
Top Contributors - Anthonia Abraham, Kim Jackson, Cindy John-Chu and Lucinda hampton
Clinically Relevant Anatomy[edit | edit source]
Wallerian degeneration is an active process of retrograde degeneration of an axon that is a result of a nerve lesion.
Usually the rate of degeneration is slower in the Central Nervous System than peripheral Nervoius system due ggto the clearance of mylein sheets.
Mechanism of Injury / Pathological Process[edit | edit source]
The pathological process of a walleroian degeneration is in 4 stages;
- Axon Degeneration; Within approximately 30 minutes of injury, there is a separation of the proximal and distal ends of the nerve. After a short latency period of the transected membranes are sealed until degeneration. This is marked by the formation of axonal spheroids. The degeneration process is usually slower in the CNS and shorter in PNS
- mylien Clerance
- regeneration
https://www.youtube.com/watch?v=EcX7DWjC-7o
Clinical Presentation[edit | edit source]
Most patients have presentations of nerve damage as the nerves are degenerated.
These presentations may include[2]
- Paralysis of associated structures to denervated nerves
- Gradual onset of numbness, prickling, or tingling in your feet or hands, which can spread upward into your legs and arms
- Sharp, jabbing, throbbing, freezing, or burning pain
- Extreme sensitivity to touch
- Lack of coordination and falling
- Muscle weakness or paralysis if motor nerves are affected
- Neuromatous or causalgia pain
Diagnostic ProceduresElectromyography[edit | edit source]
- Nerve Conduction Studies
- Pain assessment
- Sensation deficit and skin condition
- Muscle strength/loss
- Functional deficits
- Balance deficits
- Joint stiffness
- Emotional stress Outcome M
Outcome Measures[edit | edit source]
Depends on various criteria but could include:
- Oxford scale
- Romberg or Berg balance test
- Visual analogue scale
- Short form McGill pain questionnaire
- Nine-hole peg test
(see Outcome Measures Database)
Management / Interventions[edit | edit source]
Cryotherapy[1],
Differential Diagnosis[edit | edit source]
add text here relating to the differential diagnosis of this condition
Resources[edit | edit source]
add appropriate resources here