Felty Syndrome: Difference between revisions
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== Case Reports/ Case Studies == | == Case Reports/ Case Studies == | ||
*Felty's Syndrome with hyperthyroidism: A Case Report and Literature Review& | *Felty's Syndrome with hyperthyroidism: A Case Report and Literature Review ([http://eds.b.ebscohost.com/ehost/detail/detail?vid=7&sid=1a706434-0f09-499b-a86b-1dd3362c3092%40sessionmgr111&hid=127&bdata=JmxvZ2luLmFzcCZzaXRlPWVob3N0LWxpdmUmc2NvcGU9c2l0ZQ%3d%3d#AN=94086163&db=a9h view article in ebscohost]) | ||
*A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma | *A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma | ||
*A Case of Adult-onset Felty Syndrome in Juvenile Rheumatoid Arthritis | *A Case of Adult-onset Felty Syndrome in Juvenile Rheumatoid Arthritis | ||
*Surgical Management of Portal Hypertension in Felty's Syndrome: A Case Report and Literature Review | *Surgical Management of Portal Hypertension in Felty's Syndrome: A Case Report and Literature Review | ||
*Diagnosis of Felty's Syndrome, distinguished from hematology cal neoplasm: A Case Report | *Diagnosis of Felty's Syndrome, distinguished from hematology cal neoplasm: A Case Report | ||
Revision as of 18:53, 5 April 2016
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - Abby Janszen, Shannon Stenger, Rucha Gadgil, Uchechukwu Chukwuemeka, WikiSysop, Kim Jackson, Claire Knott, Lucinda hampton, 127.0.0.1, Khloud Shreif and Elaine Lonnemann
Definition/Description[edit | edit source]
Felty Syndrome (FS), a rare complication of rheumatoid arthritis (RA), was first described by Dr. Augustus Felty in 1924. It is characterized by a triad of symptoms: seropositive RA with severe joint involvement, a low white blood cell count (neutropenia), and an enlarged spleen (splenomegaly). However, the triad is not required for diagnosis. Splenomegaly and severe joint involvement are not always present in some people with FS, and some people can even present with no symptoms. Neutropenia is the hallmark symptom of FS and is key for diagnosis. FS can be a potentially life-threatening, serious systemic condition due to its increased risk for infection during an immunosuppressed state of RA.Cite error: Invalid <ref>
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Prevalence[edit | edit source]
The prevalence of FS is an estimate 10 cases per 100,000 people. It is seen in about 1-3% cases of RA, making it a rare rheumatological disorder. Cite error: Invalid <ref>
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FS is three times more common in females than males. However, early occurrence is more common in males. It more commonly affects the Caucasian population, and the mean age of those presenting with FS is between 50-70 years old.Cite error: Invalid <ref>
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Characteristics/Clinical Presentation[edit | edit source]
Aside from the classic triad of characteristics of FS, which are RA, neutropenia, and splenomegaly, other signs and symptoms can also present themselves in this rare disorder, as well.Cite error: Invalid <ref>
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tag; name cannot be a simple integer. Use a descriptive title Some of these other signs and symptoms include: Cite error: Invalid <ref>
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- Painful, stiff, swollen joints (hands, feet, arms)
- Fever
- Weight loss
- Fatigue
- Skin discoloration (especially an abnormal brown pigmentation of the leg)
- Ulcers (especially on the lower leg)
- Enlarged liver (hepatomegaly)
- Possible anemia, thrombocytopenia, or vasculitis
It should also be understood that splenomegaly is not always present in FS, and it could indicate other complications (see Associated Co-morbidities).Cite error: Invalid <ref>
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Associated Co-morbidities[edit | edit source]
Despite the associated signs and symptoms accompanying FS, other associated co-morbidities can occur, as well. Infections are common, especially due to neutropenia, and these infections primarily occur at the skin and pulmonary tracts. Nonetheless, neutropenia in FS can also lead to increased risk for cancers, especially Non-Hodgkins Lymphoma. Cite error: Invalid <ref>
tag; name cannot be a simple integer. Use a descriptive titleFurthermore, hepatomegaly, lymphadenopathy, episcleritis, sicca syndrome, eyelid necrosis, pleuritic, neuropathy, portal hypertension, liver involvement, such as portal fibrosis or cirrhosis, and anemia can also arise from FS. Cite error: Invalid <ref>
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Additionally, splenomegaly, one of the characteristics of FS, can indicate other complications, such as liver cirrhosis, brucellosis, visceral leishmaniasis, bacterial endocarditis, histoplasmosis, amyloidosis, and abdominal pain. Cite error: Invalid <ref>
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports/ Case Studies[edit | edit source]
- Felty's Syndrome with hyperthyroidism: A Case Report and Literature Review (view article in ebscohost)
- A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma
- A Case of Adult-onset Felty Syndrome in Juvenile Rheumatoid Arthritis
- Surgical Management of Portal Hypertension in Felty's Syndrome: A Case Report and Literature Review
- Diagnosis of Felty's Syndrome, distinguished from hematology cal neoplasm: A Case Report
Resources
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Recent Related Research (from Pubmed)[edit | edit source]
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References[edit | edit source]
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