- 1 Definition/Description
- 2 Prevalence
- 3 Characteristics/Clinical Presentation
- 4 Associated Co-morbidities
- 5 Medications
- 6 Diagnostic Tests/Lab Tests/Lab Values
- 7 Etiology/Causes
- 8 Systemic Involvement
- 9 Medical Management (current best evidence)
- 10 Physical Therapy Management (current best evidence)
- 11 Differential Diagnosis
- 12 Case Reports/ Case Studies
- 13 Resources
- 14 References
Purpura is a hemorrhagic condition that occurs when not enough normal platelets are available to plug damaged vessels or prevent leakage from even minor injury to normal capillaries. Purpura is characterized by movement of blood into the surrounding tissue (extravasation), under the skin, and through mucous membranes, producing spontaneous ecchymoses (bruises) and petechiae (small, red patches) on the skin. Purpura measure between 4 and 10 mm (millimeters) in diameter. When purpura spots are less than 4 mm in diameter, they are called petechiae. Purpura spots larger than 1 cm (centimeter) are called ecchymoses. There are many different types of purpura. Their classification depends on the appearance or cause of the condition.
Idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia. ITP has two distinct clinical syndromes, with typical manifestation of an acute condition in children (spontaneous resolution within 2 months) and a chronic condition in adults (lasting longer than 6 months).
- The incidence of ITP in adults is approximately 66 cases per 1,000,000 per year
- An average estimate of the incidence in children is 50 cases per 1,000,000 per year.
- Peak prevalence occurs in adults aged 20-50 years.
- Peak prevalence occurs in children aged 2-4 years.
- Approximately 40% of all patients are younger than 10 years.
Characteristics/Clinical PresentationPhysical signs and symptoms include:
- Easy or excessive bruising (purpura)
- Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs
- Bleeding from the gums or nose
- Blood in urine or stools
- Unusually heavy menstrual flow 
- Non-blanchable lesions 
Idiopathic thrombocytopenic purpura can occur in anyone at almost any age, but these factors increase the risk: 
- Your sex. Women are two to three times more likely to develop ITP than men are.
- Recent viral infection. Many children with ITP develop the disorder after a viral illness, such as mumps, measles, influenza or a respiratory infection.
Image Available from: http://immunethrombocytopenicpurpura.com
ITP is associated with a considerable number of medical conditions including hematological diseases, dermatological conditions, oral conditions, viral infections (such as Hepatitis C, HIV, measles, and mumps), gastrointestinal, bleeding, and autoimmune disorders. One possible cause of associated signs and symptoms could be due to an adverse drug reaction. However, further research is needed to identify the cause and extent of the association between these conditions and ITP 
A detailed description of The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia can be viewed here:
The primary focus of a pharmaceutical approach to the treatment of ITP is to raise the individual’s platelet count. They may also be asked to stop taking medications that impair platelet function, such as aspirin, blood thinners, and ibuprofen .
The doctor may start with a corticosteroid medication, which can help increase the platelet count by decreasing the activity of the immune system. It usually takes about two to six weeks for their platelet count to return to a safe level. When it does, the doctor will discontinue the drug.
If your purpura is causing severe bleeding, your doctor may give you an intravenous medication called intravenous immunoglobulin (IVIG). They may also give you IVIG if you need to increase your platelet count rapidly before surgery. This treatment is usually effective in increasing your platelet count, but the effect is usually only in the short term. It can cause side effects such as headache, nausea, and fever .
Other drug therapies
The latest drugs used to treat purpura are romiplostim (Nplate) and eltrombopag (Promacta). These medications cause bone marrow to produce more platelets, which reduces the risk of bruising and bleeding. Potential side effects include:
- joint or muscle pain
- increased risk of blood clots
- acute respiratory distress syndrome
Biologic therapy, such as the drug rituximad (Rituxan), can help decrease the immune system response. It’s mostly used to treat patients with severe thrombocyotopenic purpura and patients for whom corticosteroid treatment isn’t effective. Side effects may include:
- low blood pressure
- sore throat
- fever 
Diagnostic Tests/Lab Tests/Lab Values
Frequently, the diagnosis can be established on the basis of a careful history and physical examination, and a few key laboratory tests. Indicated tests include a complete blood cell count with platelet count, a peripheral blood smear, and prothrombin and activated partial thromboplastin times 
- A complete blood count. This test checks the number of red blood cells, white blood cells, and platelets in your blood. In ITP, the red and white blood cell counts are normal, but the platelet count is low.
- A blood smear. For this test, some of your blood is put on a slide. A microscope is used to look at your platelets and other blood cells.
- Bone marrow exam. This test may be used to help identify the cause of a low platelet count, though the American Society of Hematology doesn't recommend this test for children with ITP 
Thrombocytopenia can be caused by decreased production or increased destruction of platelets. Historically, ITP was believed to be caused by increased platelet destruction at a rate that exceeded production by a compensating bone marrow. However, new knowledge has questioned this model, providing evidence that platelet production is also decreased in many patients with ITP.
In people with ITP, an unknown cause leads antibodies produced by the immune system to attach themselves to the platelets, marking the platelets for destruction. The spleen, which helps the body fight infection, recognizes the antibodies and removes the platelets from your system. The result of this case of mistaken identity is a lower number of circulating platelets than is normal.
Image Available from: www.nplate.com
ITP directly affects the dermatologic and hematologic systems. It does not directly have any other systemic involvement. However, the section above titled "Associated Co-morbidities" includes some of the co-morbidities associated with ITP that may have systemic involvement including the gastrointestinal or endocrine systems.
Medical Management (current best evidence)
Treatments include medications and sometimes a splenectomy to remove the spleen.
See above section titled "Medications".
If medications aren’t effective in treating your purpura, your doctor may recommend a splenectomy. Removing the spleen is a fast way of increasing your platelet count. This is because the spleen is the main body part responsible for eliminating platelets.
Physical Therapy Management (current best evidence)
Physical therapists are not able to treat or diagnose idiopathic thrombocytopenic purpura, but are able to recognize differences in skin pigmentation and can refer the patient to a suitable specialist.
If you are cleared through a physician to treat associated impairments such as general weakness, it is recommended that low-impact activities be performed over high-impact activities. Patients can have increased risk of injury, bruising, and bleeding.
Other differential diagnoses for ITP include disorders such as:
- Autoimmune disorders: SLE, antiphospholipid antibody syndrome
- Infections: HIV, HCV, EBV
- Neoplastic: CLL, lymphoma, large granular lymphocytic leukemia,
- MDS Drug effect: Heparin, quinidine, sulfa, gold
- Isolated thrombocytopenia of pregnancy
- Congenital (Wiskott-Aldrich, Bernard-Soulier, Fanconi’s anemia, etc)
- Rare: Pure megakaryocyte aplasia 
Case Reports/ Case Studies
add links to case studies here (case studies should be added on new pages using the case study template)
American Autoimmune Related Diseases Association (AARDA)
22100 Gratiot Avenue Eastpointe
East Detroit, MI 48201-2227
E-mail: [email protected]
30 Old Kings Hwy South, Suite 275
Darien, CT 06820
E-mail: [email protected]
Platelet Disorder Support Association
8751 Brecksville Road
Cleveland, OH 44141
Toll-free: 87-PLATELET (1-877-528-3538)
E-mail: [email protected]
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- Medscape [Internet]. WebMD LLC; 1994. Idiopathic Thrombocytopenic Purpura; 2016 July 22. [cited 2017 Mar 27]; [about 8 screens]. Available from: http://emedicine.medscape.com/article/779545-overview#a6
- Mayo Clinic [Internet]. Mayo Foundation for Medical Education and Research (MFMER); 1998. Idiopathic thrombocytopenic purpura (ITP) [Internet]. 2016 April 23. [cited 2017Mar27]. [about 8 screens]. Available from: http://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/home/ovc-20201208
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- Feudjo-Tepie MA, Le Roux G, Beach KJ, Bennett D, and Robinson NJ. Comorbidities of Idiopathic Thrombocytopenic Purpura: A Population-Based Study. Advances in Hematology [Internet]. 2009 [cited 2017 March 27]; 2009. Available from: https://www.hindawi.com/journals/ah/2009/963506/ DOI:10.1155/2009/963506
- Neunert C, Lim W, Cohen A, Solberg L, Crowther M. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. BLOOD [Internet]. 2011 April 21 [cited 2017 March 27]; 117(16): 4190-4207. Available from: http://www.bloodjournal.org/content/bloodjournal/117/16/4190.full.pdf
- Healthline [Internet]. Healthline Media; 2005. Purpura; 2016 June 30. [cited 2017 Mar 27]; [about 6 screens]. Available from: http://www.healthline.com/health/purpura?s_con_rec=false&r=0#Overview1
- NHLBI [Internet]. National Institutes of Health; How is Immune Thrombocytopenia Diagnosed?; 2012 March 14. [cited 2017 March 27]; [1 screen]. Available from: https://www.nhlbi.nih.gov/health/health-topics/topics/itp/diagnosis
- Kayal L, Jayachandran S, Singh K. Idiopathic thrombocytopenic purpura. Contemp Clin Dent [serial online] 2014 [cited 2017 Mar 27];5:410-4. Available from: http://www.contempclindent.org/text.asp?2014/5/3/410/137976
- Platelet Disorder Support Association. What are the Challenges of Treating and Managing ITP? [web streaming video].Youtube, 2008 December 17 [cited 2017 March 27]. Available from: https://www.youtube.com/watch?v=w82Tivwc1dE
- University of California San Francisco Department of Medicine [Internet]. San Francisco: The Regents of the University of California; 2017. Idiopathic Thrombocytopenic Purpura; 2003 December [2017 March 27]; [2 pages]. Available from: https://medicine.ucsf.edu/education/resed/Chiefs_cover_sheets/itp_update.pdf
- Mayo Clinic. Jude’s Story: A Toddlers Battle with ITP [web streaming video]. Youtube, 2014 September 24 [cited 2017 March 27]. Available from: https://www.youtube.com/watch?v=qm6-rU_Hunk
- PDSA. Platelet Disorder Support Association for People with ITP [Internet]. Cleveland, OH. Platelet Disorder Support Association; 1997. [updated 2017]. Available from https://www.pdsa.org
- ITP Foundation. ITP Foundation Helping Children with Immune Thrombocytopenic Purpura, a Rare Bleeding Disorder [Internet]. ITP Foundation; 2014 [cited 2017 March 27]. Available from: www.itpfoundation.org
- AARDA [Internet]. American Autoimmune Related Diseases Association, Inc. Eastpointe, MI. American Autoimmune Related Diseases Association, Inc. 2004 [updated 2017]. Available from: https://www.aarda.org
- National Blood Clot Alliance. Stop the Clot [Internet]. Vienna, VA: [cited 2017 March 27] Available from: https://www.stoptheclot.org
- Vascular Cures. Vascular Disease [Internet]. Redwood City, CA: Vascular Cures; [updated 2017; cited 2017 March 27]. Available from: http://www.vasculardisease.org
- Genetic and Rare Diseases Information Center (GARD) [Internet]. Gaithersburg, MD: National Center for Advancing Translational Sciences; [cited 2017 March 27]; [screen 6]. Available from: https://rarediseases.info.nih.gov/diseases/5194/idiopathic-thrombocytopenic-purpura