Original Editors - Michelle Quill from Bellarmine University's Pathophysiology of Complex Patient Problems project.
- 1 Definition/Description
- 2 Prevalence
- 3 Characteristics/Clinical Presentation
- 4 Associated Comorbidities
- 5 Medications
- 6 Diagnostic Tests/Lab Tests/Lab Values
- 7 Causes
- 8 Systemic Involvement
- 9 Medical Management (current best evidence)
- 10 Physical Therapy Management (current best evidence)
- 11 Case Reports
- 12 Resources
- 13 References
A benign osteoblastic tumor consisting of vascular osteoid tissue centrally called the Nidus and sclerotic bone peripherally. Osteoid Osteoma does not grow or behave in a locally aggressive manner, and it has no potential for malignant transformation. May initially appear on a radiograph as a small sclerotic bone island within a circular lucency.It is classified as a stage I (latent) bone tumor. In >50% of cases, the lesion occurs in the metaphysis and diaphysis of the long bones, particularly the femur and tibia. Other anatomic sites of involvement include the spine, upper extremity, pelvis, sacrum, ribs, hands, and feet.
Osteoid osteomas account for 1/8 to 1/10 of symptomatic bone tumors and 5% of all primary bone tumors. Osteoid osteomas are the 2nd most common benign primary bone tumors resulting in 10-12% of all benign tumors.
Osteoid osteomas occur in children and young adults between the ages of 7 and 25. All ages can be effected but 75-80% of patients are less than 25 years of age. The male to female ratio is 2-3:1 putting boys and young males at the greatest risk for developing osteoid osteomas.
• Local pain that is typically more frequent and severe at night
• Pain that is relieved by aspirin within 30 minutes (75% of cases)
• Pain that increases with activity and alcohol consumption
• Local swelling and point tenderness
• Most commonly found in diaphysis of long bones 70% of the time, the femur/tibia accounting for 55%, phalanges of hands and feet 20%, and the spine 10% (lamina and spinous processes)
• Around 1.5 cm in size
• Central Nidus, with circular lucency
• Osteoid Osteomas and osteoblastomas are histologically similar but differ in size, pain intensity, location, aggressiveness, and neural staining patterns
• Osteoid Osteomas are classified by their relative position to the bone: cortical, cancellous, intraarticular, and subperiosteal
Classifications (based on location)
•Most common location (80%)
•Radiolucent nidus seen within the bone cortex and surrounded by fusiform cortical thickening/laminated periosteal formation
•Intramedullary lesion; mild reactive sclerosis & difficult to identify, significantly delaying the diagnosis
•Common sites: femoral neck, posterior spine, hands & feet
•Joint effusion or synovitis
•Round mass adjacent to cortex
•Absent periosteal reaction
Due to the age of onset osteoid osteomas can easily be mis-diagnosed as a musculoskeletal disorder because when someone in their twenties reports pain, the vast majority of people assume the pain is musculoskeletal in nature. The true diagnosis is easily overlooked because epiphyseal lesions mimic intra-articular derangement and pain is typically localized to the site of the lesion, so the location of pain can be anywhere, and may coincide with common sites of musculoskeletal inflammation or strain.Another reason diagnosis is easily misled is that pain usually occurs before the lesions are visible on radiographs and in the early stages can be easily missed on a radiograph.Finally, these lesions may be associated with proliferative synovitis due to prostaglandin secretion that decreases range of motion, creates joint effusion, and can mimic inflammatory arthritis.
No known causes
Pain caused by osteoid osteomas can be relieved with aspirin and NSAIDS, which inhibit the prostaglandins released by the tumor cells. Prostaglandins cause changes in vascular pressure, which stimulates sensory nerve endings locally, causing pain. Inhibition of these prostaglandins relieves pain. . Few studies have shown lasting affects of syptom relief after long term use of NSAIDS, some studies have shown without surigical management there is a probablity of evoltion into a osteoblastoma.
Diagnostic Tests/Lab Tests/Lab Values
Osteoid osteomas can be detected on an MRI and CT scan, which are often used to identify the location of the nidus when the tumor is intra-articular. A CT scan will reveal the nidus as a small area of low attenuation surrounded by reactive bone formation, seen as a larger area of higher attenuation. 
Radiograph reveals a well demarcated area of translucency (nidus) inside the bone, often times with a central calcified dot. This is surrounded by bony sclerosis. Usually less than 1 cm in size
An osteoid osteoma can also be detected with bone scan, or scintigraphy, which will show a focal uptake of the radiotracer by the tumor.Scintigraphy is often used to detect an osteoid osteoma that is not easily seen on a radiograph, such as a vertebral tumor.
Overall, CT scans are the best imaging tool for diagnosing osteoid osteomas.
•This is an X-ray of an osteoid osteoma of the thigh(femur) with increased bone formation and subtle lucency(arrow).
•This is a CT scan of an osteoid osteoma of the thigh(femur), a small, round lytic focus(arrow) surrounded by dense bone is demonstrated.
• This is an MRI of an osteoid osteoma of the thigh(femur). There is increased bone formation(dark)surrounding a brighter spot. The bright spot represents the nidus(arrow)of the osteoid osteoma.
The actual cause of osteiod osteomas is unknown. The nidus has been found to contian abundant nerve fibers within its matrix, adjacent to areas rich in arterioles. Prostoglanden synthesis has been shown to occur in the nidus. These reports suggest an important pathophysiologic role for prostaglandins both as mediators of pain and vasodilation that may stimulate the nerve endings by increasing the blood flow within the tumor. An osteoid osteoma is a vascular lesion consisting of an area of immature bone surrounded by osteoblasts and osteoclasts. The tumor starts with the nidus, or nest of vascular osteoid tissue in the center of the tumor. The nidus then becomes surrounded by reactive bone sclerosis. After the removal of the nidus, the secondary bone sclerosis generally disappears gradually.
Systemic involvement is uncommon with an osteoid osteoma.
Stomach ulcers, heartburn and bleeding problems can occur due to the prolonged use of NSAIDs in pain management. 
Medical Management (current best evidence)
Surgical (three most common operations)
1.Open Excision- intraoperatively cut out tumor, difficult for surgeon, hard to see. Can result in longer hospital stay for patient with activity and weight bearing restrictions. Oldest method.
2. CT-guided Percutaneous Excision-CT image guidance to remove nidus with excision
3. CT-guided Radiofrequency Ablation-CT image guidance to remove nidus with heat using probe (quick recovery, most common procedure today)
Physical Therapy Management (current best evidence)
This is a link to a slide show containing three examples of different presentations of Osteoid Osteomas.
Great review of the literature specific to osteoid osteoma of the foot and ankle.
- Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H. Osteoid osteoma and osteoblastoma. The Journal of the American Academy of Orthopaedic Surgeons. https://www.ncbi.nlm.nih.gov/pubmed/22052644. Published November 2011.
- Leung, Albert HMS III. Osteoid Osteoma. http://eradiology.bidmc.harvard.edu/LearningLab/musculo/Leung.pdf
- Goodman, Snyder. Differential Diagnosis for Physical Therapists: 5th Edition. Screening for Referral. St. Louis, Missouri: Saunders Elsevier; 2013.
- Goodman CG, Fuller KS. Pathology: Implications for the Physical Thearpist, 4th Edition. St. Louis, Missouri: Saunders Elsevier; 2014.
- Atar D, Lehman WB, Grant AD. Tips of the trade. Computerized tomography--guided excision of osteoid osteoma. Orthop Rev. Dec 1992;21(12):1457-8.
- ctisus. Osteoid Osteoma Tibia on X ray. YouTube. https://www.youtube.com/watch?v=mL4H3Qzz7Bc#action=share. Published March 31, 2016. Accessed April 10, 2017.fckLR
- Lenke LG, Sutherland CJ, Gilula LA.Osteoid osteoma of the proximal femur: CT-guided preoperative localization. Orthopedics. Mar 1994;17(3):289-92 fckLR
- Osteoid Osteoma: Symptoms, Causes & Treatment. UCSF Radiology. https://radiology.ucsf.edu/patient-care/services/osteoid-osteoma#accordion-imaging-of-osteoid-osteoma. Published February 23, 2016. Accessed April 10, 2017.
- Lenke LG, Sutherland CJ, Gilula LA. Osteoid osteoma of the proximal femur: CT-guided preoperative localization. Orthopedics. Mar 1994;17(3):289-92 fckLR
- Pettine KA, Klassen RA. Osteoid-osteoma and osteoblastoma of the spine. J Bone Joint Surg Am. Mar 1986;68(3):354-61.
- Frassica FJ, Waltrip RL, Sponseller PD, et al. Clinicopathologic features and treatment of osteoid osteoma and osteoblastoma in children and adolescents. Orthop Clin North Am. Jul 1996;27(3):559-74.
- Baggat M, Robbin M. emedicine.medscape.com/article/392850-media Case Eighty Four - Osteoid Osteoma retrieved from Musculoskeletal Imaging Teaching Files at http://www.uhrad.com/msiarc/msi084.htm
- P. osteoid osteoma. YouTube. https://www.youtube.com/watch?v=G4JJv1dhEa0. Published July 30, 2016. Accessed April 10, 2017.