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Neurogenic inflammation (NI) is a physiological process in which mediators are released directly from the cutaneous nerves to initiate an inflammatory reaction in response to tissue damage or a painful stimuli. This results in the production of local inflammatory responses including erythema, swelling, temperature increase, tenderness, and pain.
Neurogenic inflammation has also been implicated in the pathophysiology of numerous diseases, including complex regional pain syndrome, migraine, and irritable bowel and bladder syndromes. However,in the setting of wound healing, neurogenic inflammation helps maintain tissue integrity and facilitate tissue repair.
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- Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation – the peripheral nervous system’s role in host defense and immunopathology. Nat Neurosci. 2012;15:1063-1067.