Wrist and Hand Osteoarthritis

Original Editor - Kristin Johnson and Yuliya Bugera as part of the Temple University EBP Project Top Contributors - Yuliya Bugera, Johnathan Fahrner, Lucinda hampton, Admin, Rachael Lowe, Kristin Johnson, Kim Jackson, Venugopal Pawar, Anas Mohamed, Scott A Burns, WikiSysop, Evan Thomas, Shaimaa Eldib and Amrita Patro  

Introduction

Hand osteoarthritis (OA) is a common chronic condition involving one or more joints of the thumb and fingers. It is associated with pain, reduced grip strength, loss of range of motion (ROM), and joint stiffness, leading to impaired hand function and difficulty with daily activities.

• Estimates of the prevalence of symptomatic hand OA range from 13% to 26% and are greater in women

Evidence suggests the following:

• Long-term use of a night splint offers significant benefits to improve pain, hand function, strength, and ROM for patients with OA;
• Programs of joint protection, advice, and home exercises are effective at improving grip strength and hand function;
• Low-level laser therapy is effective at improving ROM
• No rehabilitation interventions were found to improve stiffness.

Clinically Relevant Anatomy

The wrist and hand are composed of 27 bones: 8 bones of the wrist, 5 metacarpals and 14 bones of the phalanges.

In this degenerative disorder, the articular cartilage wears away, exposing the bones. Cartilage is an elastic connective tissue whose purpose is to allow for a smooth, gliding motion between joints.

Epidemiology

Epidemiologic studies of hand osteoarthritis, especially symptomatic hand osteoarthritis, are limited.

• Symptomatic hand osteoarthritis is a common disorder among this elderly Caucasian population, especially among women. Most common musculoskeletal disorder worldwide affecting the hands
• The most commonly involved joints were the distal interphalangeal and proximal interphalangeal joints, followed by the base of thumb joint.
• The symptomatic hand osteoarthritis is associated with weak grip strength and limits several daily functional activities.
• Age: Incidence increases after 55 in women; Rate of progression increases with age

• Gender: More common and more severe in women; Observed sex differences become evident after menopause;The typical locations of degeneration in patients with osteoarthritis are the distal and interphalangeal joints of the hand 
• Genetics: Women; Gene mutations that code for collagen II may increase the risk of developing early OA; Role of human leukocyte antigen (HLA) types regarding the risk of OA remains much debated
• Handedness: HOA mostly occurs on the dominant hand
• Continuing to increase as the majority of our population increases
  

Many people may think that symptomatic hand osteoarthritis is not a common disease, because patients with hand osteoarthritis seldom seek medical care.

A 2002 study found that 13.2 percent of men and 26.2 percent of women aged 70 or more years had at least one joint with symptomatic osteoarthritis.

Among subjects within the same age range in the study also reported the prevalence of symptomatic hand osteoarthritis was higher than that of symptomatic knee osteoarthritis and many subjects with symptomatic hand osteoarthritis in the elderly population do not seek medical care

Pathological Process

Osteoarthritis is a disorder of the entire synovial joint organ and involves more structures than articular cartilage. The tissue changes that occur in the hand and wrist are a result of imbalance between catabolic and anabolic repair activity. Current evidence states that the subchondral bone may be the primary etiologic agent in osteoarthritis and joint cartilage is simply the final target of the process. Periarticular bone changes occur very early in the development of OA and these changes can be segregated into distinct patterns based on the anatomic location and pathogenic mechanisms. There is a progressive increase in subchondral plate thickness, alterations in the architecture of subchondral trabecular bone, formation of new bone at joint margins (osteophytes), and development of sub chondral bone cysts. Once the pathology reaches the articular cartilage, the cartilage thins and the joint space narrows. This causes sclerosis of the subchondral bone due to the new mechanical load placed on the affected joint.

Clinical Presentation

• Swelling
• Stiffness, particularly in the mornings
• Pain, swelling and stiffness primarily targeted to DIP, PIP, thumb base, index and middle MCP joints.
• Muscle weakness
• Difficulty gripping and twisting objects (doorknobs)
• Presence of Heberden (on distal IP joints) or Bouchard nodes (on proximal IP joints) or bony enlargements.
    clinical hallmark*
  
  

                 

Diagnostic Procedures

Diagnosis difficult to make due to the number of joints involved, the broad spectrum of severity and possible subsets of criteria which may exist. As well as laboratory tests there are also other factors that are used to aid the diagnosis of hand OA, such as imaging, risk factors and clinical criteria.

Laboratory Tests

Laboratory markers such as rheumatoid factor (RF) and erythrocyte sedimentation rate (ESR) may be suggestive of rheumatoid arthritis but blood tests are not required to diagnose hand OA but recommended to exclude potential coexisting diseases

Imaging

Radiographs (gold standard). Note joint space narrowing; osteophytes; subchondral bone: sclerosis, cysts, erosion. Kellgren-Lawrence grading allows a wide range of interpretations for each grade, reducing inter-observer reliability. Verbruggen and colleagues suggest an easy and reproducible scoring method, using numeric scores for radiographs

MRI and Scintigraphy are often used in the early diagnosis of hand OA but their efficacy is yet to be established.

Risk Factors

There are many risk factors associated with hand OA and the presence of these (see list below) will help to support a diagnosis

• Female gender
• Increasing age over 40
• Menopausal status
• Family history
• Obesity
• Joint laxity
• Prior hand injury
• Occupational and recreation-related usage

Clinical Diagnostic Criteria

A study by Altman et al in 1990 developed clinical criteria for the diagnosis of OA of the hand based on data collected from multi-centred studies

• Presence of hand pain, aching, or stiffness plus
• Hard tissue enlargement of at least 2 of 10 selected joints
• Plus less than 3 swollen metacarpophalangeal joint
• Plus either hard tissue enlargement of at least 2 distal interphalangeal
• Joints or deformity of at least 1 of 10 selected joints

Outcome Measures

Outcome measures are a useful tool for determining the efficacy of physiotherapy interventions, especially the benefits of exercise and patient education.

• Score for Assessment and quantification of Chronic Rheumatic Affections of the Hands (SACRAH)
• Functional Index for Osteoarthritis of the Hand (FIHOA)
• DASH/QuickDash
  

Conservative Treatment

A Systematic Review of Conservative Interventions for Osteoarthritis of the Hand
          

                                                                Summary of Key Evidence

Intervention	Results	Level of Evidence
Hand Exercises	Increased Grip Strength Improved Function Improved ROM Pain Reduction	Moderate
Joint Protection Exercises and Provision of Adaptive Equipment	Increased Hand Function Pain Reduction	Moderate
Paraffin	Pain Reduction Improved ROM Improved Function	Weak
Low-level Continuous Heat Wrap	Pain Reduction Increased Grip Strength	Moderate
CMC Orthotics (splints)	Hand Pain Redcution Improved Hand Function Increased Grip Strength	Moderate

Pharmacological Treatment

There is no pharmacological intervention to treatment to cure OA but instead, this intervention is indicated to improve function by providing temporary relief of symptoms

• Intra-articular steroid injections
• Analgesics
• Non-steroidal anti-inflammatory drugs (NSAIDs)

Surgery    

The main indication for surgery is pain relief but it is very rarely the first option as it.can result in reduced function. When indicated the most common types of surgery are:

• Arthrodesis of the digits and wrist, this can be either partial or full
• Arthoplasty of the the knuckles or wrist
  

Differential Diagnosis

There are many conditions that are similar to Hand OA and definite diagnosis is based on a combination of findings such as, clinical manifestations, risk factors, radiographic changes and laboratory tests. Other conditions that have similar symptoms include:

• Psoriatic arthritis (one ray or just DIP joints targeted)
• Rheumatoid arthritis (targets MCP, PIP, wrist joints)
• gout (elevated serum urate levels)
• hemochromatosis (targets MCP and wrist joints)
• Reiter’s arthritis

Key Evidence

• Diagnosing hand osteoarthritis:
  Zhang W, Doherty M, Leeb BF, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009; 68:8-17.

• Conservative treatment for hand osteoarthritis:
  Valdes K, Marik T. A systematic review of conservative interventions for osteoarthritis of the hand. Journal of Hand Therapy. 2010; 23: 334–351. Walker MJ. Manual Physical Therapy Examination and Intervention of a Patient with Radial Wrist Pain: A Case Report. Journal of Orthopaedic and Sports Physical Therapy. 2004; 34 (12): 761-769.

Resources

• Arthritis Foundation
• Arthritis - Centers for Disease Control and Prevention
• Arthritis - The American Academy of Orthopaedic Surgeons

Case Studies

Walker et al. (2004) used an impairment based manual physical therapy approach in which the intervention included manual physical therapy in the clinic and self-mobilizations as part of a home exercise program. This impairment based approach appears to be beneficial in the treatment of CMC joint dysfunction and lead to the expeditious resolution of pain and return to full activity. Results demonstrate the clinically significant differences on the PSFS and NPRS and can be seen on the diagram below.