Hepatitis A, B, C

Original Editors -Emily Schmidt Allyson Simmonds  from Bellarmine University's Pathophysiology of Complex Patient Problems project.

Top Contributors - Allyson Simmonds, Emily Schmidt, Vidya Acharya, Lucinda hampton, Kim Jackson, Admin, Elaine Lonnemann, Rujuta Naik, WikiSysop, Karen Wilson, Nupur Smit Shah, 127.0.0.1, Wendy Walker and Evan Thomas  

Introduction

Hepatitis is defined as inflammation of the liver.

• The condition can be self-limiting or can progress to fibrosis (scarring), cirrhosis or liver cancer.
• Hepatitis viruses are the most common cause of hepatitis in the world (infections, toxic substances, and autoimmune diseases can also cause hepatitis)

The most common types of viral hepatitis are Hepatitis A, Hepatitis B, and Hepatitis C. The other types of viral hepatitis are hepatitis D and E and are less frequently encountered. Based on the etiology of hepatitis, the severity can range from mild and self-limiting to severe illness requiring liver transplantation.

Hepatitis can be further classified

• Acute - inflammation of the liver lasts for less than 6 months; usually self-resolving but can cause fulminant liver failure depending on the etiology
• Chronic - inflammation/insult of the liver lasts longer than 6 months; can cause liver damage that includes liver fibrosis, cirrhosis, hepatocellular carcinoma, and features of portal hypertension leading to significant morbidity and mortality

Epidemiology

Viral Hepatitis is considered a major public health issue. Viral hepatitis infects millions of people annually causing significant morbidity and mortality.

• Chronic Hepatitis B and C infection can cause liver damage that includes liver fibrosis, cirrhosis, hepatocellular carcinoma, and features of portal hypertension.
• Viral hepatitis ends up causing 1.4 million deaths annually, and hepatitis B and C viruses are responsible for about 90% of those deaths.
• The World Health Organization (WHO) estimated that 1.3 million people have died due to hepatitis in 2015, and 1 in 3 people in the world have had infections with either hepatitis B or hepatitis C virus.
• Reportedly, infection rates show that 2 billion people infected with the hepatitis B virus, 185 million with the hepatitis C virus, and 20 million with the hepatitis E virus. 
• Hepatitis A virus affects 90% of children in high endemic regions. 
  

Characteristics/Clinical Presentation

Viral Hepatitis

Can be different in every individual depending on the type of virus causing the infection. Patients can be entirely asymptomatic or only mildly symptomatic at presentation. A small number of patients can present with rapid onset of fulminant hepatic failure.

Typically patients with viral hepatitis go through 4 phases.

• Phase 1 (viral replication phase) - Patients are usually asymptomatic in this phase, and laboratory studies are positive for markers of hepatitis.
• Phase 2 (prodromal phase) - Patients in this phase usually present with anorexia, nausea, vomiting, malaise, pruritus, urticaria, arthralgias, and fatigue. Many times these patients are misdiagnosed as having gastroenteritis or viral infection.
• Phase 3 (jaundice phase) - Patients in this phase present with dark-colored urine and pale-colored stool. Some patients develop jaundice and right upper quadrant pain with liver enlargement.
• Phase 4 (convalescent phase) - Patients typically start noticing the resolution of symptoms, and laboratory studies show liver enzymes returning to normal levels.

Hepatitis A - Usually present with symptoms similar to gastroenteritis or viral respiratory infection, including symptoms of fatigue, nausea, vomiting, fever, jaundice, anorexia, and dark urine. Symptoms usually start after the incubation period is over, and they resolve spontaneously in a majority of patients

Hepatitis B - Enter the prodromal phase after the incubation period and have symptoms of anorexia, malaise, and fatigue which are the most common initial clinical symptoms.  Some patients may experience right upper quadrant pain due to hepatic inflammation.  Once these patients progress to the jaundice phase, they develop jaundice and painful hepatomegaly.  dark-colored urine and pale-colored stools. After this phase, clinical course can be variable, some patients experience rapid improvement in the symptoms, and others can develop a prolonged illness with a slow resolution with periodic flareups.  A small number of patients can have rapid progression of the disease that can lead to fulminant hepatic failure over a few days to weeks.

Hepatitis C - Develop similar symptoms after the incubation period to those of hepatitis B virus infection during the acute infection phase with symptoms of anorexia, malaise, and fatigue.  However, 80% of patients remain asymptomatic and do not develop jaundice

Associated Co-morbidities

Some co-morbidities that may be associated with Hepatitis A, B, C include:

• Diabetes
• Obesity
• HIV
• ESRD
• Maladaptive lifestyle habits
• Poor quality of life
• Liver disease
• Disorders of lipid metabolism
• Non-traumatic joint disorders
• GI disorders
• Alcoholism
• Blood-clotting disorders
• Hypertension

Causes

• Hepatitis A and E are typically caused by ingestion of contaminated food or water. Hepatitis B, C and D usually occur as a result of parenteral contact with infected body fluids. Common modes of transmission for these viruses include receipt of contaminated blood or blood products, invasive medical procedures using contaminated equipment and for hepatitis B transmission from mother to baby at birth, from family member to child, and also by sexual contact.
• Most of the time, hepatitis results from hepatitis viruses A, B, C, D, and E. Hepatitis A, B, and C are endemic to the United States with hepatitis A, B, and C viruses causing 90% of acute viral hepatitis in the United States and Hepatitis C being the most common cause of chronic hepatitis.

Systemic Involvement

Variable systemic involvement can occur with Hepatitis due to the nature of the virus causing a widespread infection in the body.  Most predominantly the infection involves the liver and lymphatic system.  Other systemic areas of involvement include progression into renal, endocrine, dermatological, cardiovascular, rheumatologic, and central nervous system diseases.

Diagnostic Tests

Depending on the cause and how advanced the disease is, hepatitis typically is diagnosed with some combination of blood tests, imaging tests, and liver biopsy.

1. Blood tests are run to

• Detect the presence of a specific hepatitis virus or for antibodies produced by the immune system to fight the virus
• May include- Liver Function Tests, Antibody Tests,Antibody Tests.
• Look for signs of liver damage .

2. Imaging tests - cannot detect a viral infection of the liver, but can reveal inflammation, changes in size, and tumors that can be consequences of chronic infection or liver disease caused by hepatitis.

3. Liver biopsy - a section of tissue taken from the liver and evaluated under a microscope to look for identifying features disease.The most common type of liver biopsy is a percutaneous biopsy,

Management

The most effective treatment plan for viral hepatitis uses a multifaceted approach and varies depending on the specific type of viral hepatitis. Treatment plans are individualized to best fit the patient's age, medical history, and type and stage of the disease. The goal of treatment is to stop or slow the progression of damage to the liver and minimize and quickly treat any complications, such as such as chronic hepatitis, cirrhosis of the liver, liver failure, liver cancer and death.

The first step in treatment is prevention.

With all three of the diseases preventing contraction of the virus, and therefore the infection is key. Prevention can help avoid passing on the disease or contracting the illness. The risk of infection can be reduced by:

• Receiving Hepatitis A and B vaccines
• Avoiding unnecessary and unsafe injections
• Avoiding unsafe blood products
• Avoiding unsafe sharps and waste collection and disposal
• Avoiding the use of illicit drugs and sharing injection equipment
• Avoiding unprotected sex with infected individuals
• Avoiding the sharing of sharp personal items that may be contaminated with infected blood
• Avoiding tattoos, piercings, and acupuncture performed with contaminated equipment

Viral hepatitis is not treated with antibiotics because it is caused by a virus and antibiotics are not effective in treating viral infections. Some forms of viral hepatitis are treated with antiviral medications. General treatment of viral hepatitis also includes rest and ensuring good nutrition.

People with viral hepatitis should not drink alcohol or take any supplements, over-the-counter medications or prescription drugs without consulting their health care provider, because they can cause liver damage.

For serious cases of viral hepatitis eg if liver damage, hospitalization may be necessary. Treatment in the hospital may include medications, a liver biopsy, and other diagnostic testing and treatment.

Complications of viral hepatitis are also treated as appropriate. Treatment of the life-threatening complications of liver failure may include liver transplant for some people. This major surgical procedure involves using a healthy donor liver to replace a severely diseased liver.

Vaccines - Immunisation for prevention of hepatitis A and B.

Physical Therapy Management

A multifaceted approach is needed in the treatment of Hepatitis A, B, and C. No specific physical therapy intervention is appropriate for the specific infection of Hepatitis, but Hepatitis may likely be a comorbidity of a patient seen in physical therapy. With any other medical condition, it is important to educate patients on their disease and risk factors to promote awareness and improvement in their healthy lifestyle.  In physical therapy, an emphasis on proper musculoskeletal health will be an important foundation for the patient's overall health. Stretching to improve flexibility could help alleviate symptoms of muscle pain. It is also important for the patient to remain physically active in order to maintain the healthiest lifestyle possible and prevent the patient from developing secondary co-morbidities due to inactivity. General strengthening and aerobic activity might be appropriate for a deconditioned patient. Individualizing a physical therapy program focusing on the impairments of the patient is of utmost importance for any patient.

During physical activity, it is important to monitor the patient for signs and symptoms of fatigue. For Hepatitis A bed rest is the recommended form of treatment and being aware of the acuteness of the Hepatitis infection is important when screening for physical therapy. Supportive therapy and patient education are used to ensure the patient is comfortable and has an adequate nutritional balance for all three infections. It is also important to remind the patient to refrain from the use of alcohol or intake of fatty substances.

Complications

Complications of viral hepatitis include chronic infection with chronic active hepatitis, acute or subacute hepatic necrosis, cirrhosis, liver failure, hepatocellular carcinoma in patients with hepatitis B or C infection.

Patients who have hepatitis B infection

• Are at high risk of developing chronic infection.
• Also at significant risk of developing hepatocellular carcinoma, which is responsible for 45% of primary liver cancer worldwide.
• About 1% of patients can also develop fulminant hepatic failure, and the mortality rate is about 80% in those patients.

Patients who have hepatitis C infection

• About 75 to 85% of patients with hepatitis C end up developing chronic infection and about 20% of those patients end up developing cirrhosis and eventually hepatocellular carcinoma.
• Cirrhosis developing from hepatitis C infection is a leading cause of liver transplantation in the United States.
• Also have a high risk of developing extrahepatic complications including cryoglobulinemia which can lead to rash, vasculitis, and glomerulonephritis secondary to deposition of immune complexes in the small vessels, non-Hodgkin lymphoma, focal lymphocytic sialadenitis, autoimmune thyroiditis,

Case Reports/ Case Studies

Hepatitis C Case Study