Liver Function Tests: Difference between revisions

No edit summary
No edit summary
Line 6: Line 6:
== Components of Liver Function Tests ==
== Components of Liver Function Tests ==
{| class="wikitable"
{| class="wikitable"
!'''Alanine Transaminase;''' Normal value: 0-45 IU/L
!'''Alanine Transaminase (ALT);''' Normal value: 0-45 IU/L
'''Aspartate Transaminase;''' Normal value: 0-35 IU/L<ref>Lala V, Goyal A, Bansal P, Minter D. [https://www.ncbi.nlm.nih.gov/books/NBK482489/ Liver function tests]. StatPearls. 2020 Apr 28.</ref>
'''Aspartate Transaminase (AST);''' Normal value: 0-35 IU/L<ref name=":0">Lala V, Goyal A, Bansal P, Minter D. [https://www.ncbi.nlm.nih.gov/books/NBK482489/ Liver function tests]. StatPearls. 2020 Apr 28.</ref>
|-
|-
|'''Causes of raised transaminases:'''
|'''Causes of raised transaminases:'''
Line 22: Line 22:
* Endocrine disease: hypothyroidism, Addison's disease.
* Endocrine disease: hypothyroidism, Addison's disease.
* Diseases of striate muscle.
* Diseases of striate muscle.
* Glycogen storage diseases.<ref>Limdi JK, Hyde GM. [https://pmj.bmj.com/content/79/932/307.full Evaluation of abnormal liver function tests]. Postgraduate medical journal. 2003 Jun 1;79(932):307-12.</ref>
* Glycogen storage diseases.<ref name=":1">Limdi JK, Hyde GM. [https://pmj.bmj.com/content/79/932/307.full Evaluation of abnormal liver function tests]. Postgraduate medical journal. 2003 Jun 1;79(932):307-12.</ref>
|}
|}
 
{| class="wikitable"
== Sub Heading 3 ==
!'''Alkaline phosphatase (ALP):''' 30–120 IU/l<ref name=":0" />
|-
|'''Causes of raised ALP'''
* Physiological
** Women in the third trimester of pregnancy.
** Adolescents.
** Benign, familial (due to increased intestinal ALP).
* Pathological
** Bile duct obstruction.
** Primary biliary cirrhosis.
** Primary sclerosing cholangitis.
** Drug induced cholestasis—for example, anabolic steroids.
** Adult bile ductopenia.
** Metastatic liver disease.
** Bone disease.<ref name=":1" />
|} 


== Resources  ==
== Resources  ==

Revision as of 11:18, 29 November 2020

This article or area is currently under construction and may only be partially complete. Please, come back soon to see the finished work. Thank you! (29/11/2020)

Introduction[edit | edit source]

Groups of blood tests performed to know the condition of a liver of a patient are known as liver function tests (LFT) or liver panel or hepatic function panel or hepatic panel.[1]

Components of Liver Function Tests[edit | edit source]

Alanine Transaminase (ALT); Normal value: 0-45 IU/L

Aspartate Transaminase (AST); Normal value: 0-35 IU/L[2]

Causes of raised transaminases:
  • Alcohol.
  • Medications: non-steroidal anti-inflammatory drugs, antibiotics, HMG Co-A-reductase inhibitors, antiepileptic drugs, antituberculous drugs, herbal medications, illicit drug use.
  • Non-alcoholic steatohepatosis.
  • Chronic hepatitis B and C.
  • Autoimmune diseases.
  • Hemochromatosis.
  • Wilson's disease.
  • Congestive cardiac failure and ischaemic hepatitis.
  • ɑ1-Antitrypsin deficiency.
  • Coeliac disease.
  • Endocrine disease: hypothyroidism, Addison's disease.
  • Diseases of striate muscle.
  • Glycogen storage diseases.[3]
Alkaline phosphatase (ALP): 30–120 IU/l[2]
Causes of raised ALP
  • Physiological
    • Women in the third trimester of pregnancy.
    • Adolescents.
    • Benign, familial (due to increased intestinal ALP).
  • Pathological
    • Bile duct obstruction.
    • Primary biliary cirrhosis.
    • Primary sclerosing cholangitis.
    • Drug induced cholestasis—for example, anabolic steroids.
    • Adult bile ductopenia.
    • Metastatic liver disease.
    • Bone disease.[3]

Resources[edit | edit source]

  • bulleted list
  • x

or

  1. numbered list
  2. x

References[edit | edit source]

  1. ↑ Teshome G, Ambachew S, Fasil A, Abebe M. Prevalence of liver function test abnormality and associated factors in type 2 diabetes mellitus: a comparative cross-sectional study. Ejifcc. 2019 Oct;30(3):303.
  2. ↑ 2.0 2.1 Lala V, Goyal A, Bansal P, Minter D. Liver function tests. StatPearls. 2020 Apr 28.
  3. ↑ 3.0 3.1 Limdi JK, Hyde GM. Evaluation of abnormal liver function tests. Postgraduate medical journal. 2003 Jun 1;79(932):307-12.
Retrieved from "https://www.physio-pedia.com/index.php?title=Liver_Function_Tests&oldid=260750"