Lhermitte's Sign: Difference between revisions
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== Introduction == | == Introduction == | ||
Lhermitte's Sign is also known as "Lhermitte's Phenomenon", or also referred to as "Barber Chair Phenomenon". It is described as a transient sensation of an electric shock extending down the spine and/or extremities upon flexion of the neck, often a sequela of neurologic disease.<ref>Teoli D, Rocha Cabrero F, Ghassemzadeh S. [https://pubmed.ncbi.nlm.nih.gov/29630289/ Lhermitte Sign]. 2021 Jun 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 29630289. </ref> In this condition, upon the flexion of the nape, the | Lhermitte's Sign is also known as "Lhermitte's Phenomenon", or also referred to as "Barber Chair Phenomenon". It is described as a transient sensation of an electric shock extending down the spine and/or extremities upon flexion of the neck, often a sequela of neurologic disease.<ref>Teoli D, Rocha Cabrero F, Ghassemzadeh S. [https://pubmed.ncbi.nlm.nih.gov/29630289/ Lhermitte Sign]. 2021 Jun 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 29630289. </ref> In this condition, upon the flexion of the nape, electric shock like trigger or paresthesia<ref>Koehler PJ. Lhermitte, Jean. [https://www.sciencedirect.com/science/article/pii/B9780123851574009453 Encyclopedia of the Neurological Sciences (Second Edition)] 2014, Page 884</ref>, radiates down the spine, often into the upper and lower extremities, and sometimes to the trunk.<ref name=":0">Khare S, Seth D. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445188/ Lhermitte's sign: the current status]. Annals of Indian Academy of Neurology. 2015 Apr;18(2):154.</ref> It only lasts for short period of time. It results from the stimulation of irritated nerves or the [[Spinal cord anatomy|spinal cord]] and causes a similar sensation/irritation to hitting the elbow.<ref>Eske Jamie, Hammond Nancy, MD. [https://www.medicalnewstoday.com/articles/323889 What is Lhermitte's sign?] MedicalNewsToday. March 17 2021</ref> Lhermitte's sign can also be described as a symptom, as it is spontaneously explained by patients, on their own.<ref>Garcia-Moreno JM, Izquierdo G. [https://europepmc.org/article/med/11927103 Lhermitte's sign]. Neurologia (Barcelona, Spain). 2002 Mar 1;17(3):143-50.</ref> It is often one of the symptoms that people mention when they’re first diagnosed with [[MS Multiple Sclerosis|multiple sclerosis]].<ref>Brown Tracy, Melinosky Christopher. [https://www.webmd.com/multiple-sclerosis/lhermittes-sign-what-is-how-treat Lhermitte’s Sign: What Is It? How Do You Treat It?] WebMD. July 23 2020</ref> | ||
== History == | == History == | ||
Lhermitte's sign was first described by Marie and Chatelin in 1917. The first reference to the symptom was described by Beriel and Devic in 1918 in [[MS Multiple Sclerosis|multiple sclerosis (MS)]]. In 1924, Lhermitte ''et al.'' described in detail a patient with MS and electric dysesthesias.<ref name=":0" /> Jacques Jean Lhermitte, a forefather of modern clinical neurology, was a French neurologist conducting the majority of his research between 1908 and 1957. Lhermitte was famously recognized for his eponymously named “Lhermitte’s sign.”<ref>Chu DT, Hautecoeur P, Santoro JD. [https://journals.sagepub.com/doi/10.1177/1352458518820628 Jacques Jean Lhermitte and Lhermitte’s sign.] Multiple Sclerosis Journal. 2020 Apr;26(4):501-4.</ref> Lhermitte's sign has been associated with the intensity-modulated radiotherapy (IMRT) for head and neck cancer patients. It is one of the late term effects following IMRT in these patients.<ref>Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A. [https://pubmed.ncbi.nlm.nih.gov/22284690/ Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms.] International Journal of Radiation Oncology* Biology* Physics. 2012 Aug 1;83(5):1528-33.</ref> | Lhermitte's sign was first described by Marie and Chatelin in 1917. The first reference to the symptom was described by Beriel and Devic in 1918 in [[MS Multiple Sclerosis|multiple sclerosis (MS)]]. In 1924, Lhermitte ''et al.'' described in detail a patient with MS and electric dysesthesias.<ref name=":0" /> Jacques Jean Lhermitte, a forefather of modern clinical neurology, was a French neurologist conducting the majority of his research between 1908 and 1957. Lhermitte was famously recognized for his eponymously named “Lhermitte’s sign.”<ref>Chu DT, Hautecoeur P, Santoro JD. [https://journals.sagepub.com/doi/10.1177/1352458518820628 Jacques Jean Lhermitte and Lhermitte’s sign.] Multiple Sclerosis Journal. 2020 Apr;26(4):501-4.</ref> Lhermitte's sign has been associated with the intensity-modulated radiotherapy (IMRT) for head and neck cancer patients. It is one of the late term effects following IMRT in these patients.<ref>Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A. [https://pubmed.ncbi.nlm.nih.gov/22284690/ Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms.] International Journal of Radiation Oncology* Biology* Physics. 2012 Aug 1;83(5):1528-33.</ref> | ||
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== Causes == | == Causes == | ||
There are several conditions that exhibits the Lhermitte's sign: | |||
== | # '''Disease/Condition'''<ref name=":0" /> | ||
#* Multiple Sclerosis | |||
#* Head Trauma | |||
#* Cervical Spondylosis | |||
#* Transverse Myelitis | |||
#* Sub-acute combined degeneration of the cord | |||
#* Arnold-Chiari Malformation | |||
#* Arachnoiditis | |||
#* Syringomyelia | |||
#* Spinal Cord Compression/Herniation/Injury | |||
#* Spinal Cord Tumors | |||
#* Vitamin B12 Deficiency | |||
#* Systemic Lupus Erythematosus | |||
#* Bechet's disease | |||
# '''Radiation'''<ref name=":0" /> | |||
#* Radiation Myelopathy | |||
# '''Chemotherapy''' | |||
#* High dose | |||
#* Nitric Oxide Toxicity | |||
#* Oxaliplatin-Induced<ref>Amaraneni A, Seth A, Itawi EA, Chandana SR. [https://www.sciencedirect.com/science/article/abs/pii/S1533002814000966 Oxaliplatin-induced Lhermitte sign. A case report and review of literature.] Clinical colorectal cancer. 2014 Dec 1;13(4):257-9.</ref> | |||
# '''Parasitic'''<ref name=":0" /> | |||
#* Parasitic invasion of Spinal Cord | |||
#* Herpes Zoster Infection | |||
== Validity == | == Validity == | ||
== Review == | |||
== Conclusion == | |||
Revision as of 11:48, 25 November 2021
Original Editor - Shristi Maharjan
Top Contributors - Shristi Maharjan and Kim Jackson
This article is currently under review and may not be up to date. Please come back soon to see the finished work! (25/11/2021)
Introduction[edit | edit source]
Lhermitte's Sign is also known as "Lhermitte's Phenomenon", or also referred to as "Barber Chair Phenomenon". It is described as a transient sensation of an electric shock extending down the spine and/or extremities upon flexion of the neck, often a sequela of neurologic disease.[1] In this condition, upon the flexion of the nape, electric shock like trigger or paresthesia[2], radiates down the spine, often into the upper and lower extremities, and sometimes to the trunk.[3] It only lasts for short period of time. It results from the stimulation of irritated nerves or the spinal cord and causes a similar sensation/irritation to hitting the elbow.[4] Lhermitte's sign can also be described as a symptom, as it is spontaneously explained by patients, on their own.[5] It is often one of the symptoms that people mention when they’re first diagnosed with multiple sclerosis.[6]
History[edit | edit source]
Lhermitte's sign was first described by Marie and Chatelin in 1917. The first reference to the symptom was described by Beriel and Devic in 1918 in multiple sclerosis (MS). In 1924, Lhermitte et al. described in detail a patient with MS and electric dysesthesias.[3] Jacques Jean Lhermitte, a forefather of modern clinical neurology, was a French neurologist conducting the majority of his research between 1908 and 1957. Lhermitte was famously recognized for his eponymously named “Lhermitte’s sign.”[7] Lhermitte's sign has been associated with the intensity-modulated radiotherapy (IMRT) for head and neck cancer patients. It is one of the late term effects following IMRT in these patients.[8]
Pathophysiology[edit | edit source]
Causes[edit | edit source]
There are several conditions that exhibits the Lhermitte's sign:
- Disease/Condition[3]
- Multiple Sclerosis
- Head Trauma
- Cervical Spondylosis
- Transverse Myelitis
- Sub-acute combined degeneration of the cord
- Arnold-Chiari Malformation
- Arachnoiditis
- Syringomyelia
- Spinal Cord Compression/Herniation/Injury
- Spinal Cord Tumors
- Vitamin B12 Deficiency
- Systemic Lupus Erythematosus
- Bechet's disease
- Radiation[3]
- Radiation Myelopathy
- Chemotherapy
- High dose
- Nitric Oxide Toxicity
- Oxaliplatin-Induced[9]
- Parasitic[3]
- Parasitic invasion of Spinal Cord
- Herpes Zoster Infection
Validity[edit | edit source]
Review[edit | edit source]
Conclusion[edit | edit source]
References[edit | edit source]
- ↑ Teoli D, Rocha Cabrero F, Ghassemzadeh S. Lhermitte Sign. 2021 Jun 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 29630289.
- ↑ Koehler PJ. Lhermitte, Jean. Encyclopedia of the Neurological Sciences (Second Edition) 2014, Page 884
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Khare S, Seth D. Lhermitte's sign: the current status. Annals of Indian Academy of Neurology. 2015 Apr;18(2):154.
- ↑ Eske Jamie, Hammond Nancy, MD. What is Lhermitte's sign? MedicalNewsToday. March 17 2021
- ↑ Garcia-Moreno JM, Izquierdo G. Lhermitte's sign. Neurologia (Barcelona, Spain). 2002 Mar 1;17(3):143-50.
- ↑ Brown Tracy, Melinosky Christopher. Lhermitte’s Sign: What Is It? How Do You Treat It? WebMD. July 23 2020
- ↑ Chu DT, Hautecoeur P, Santoro JD. Jacques Jean Lhermitte and Lhermitte’s sign. Multiple Sclerosis Journal. 2020 Apr;26(4):501-4.
- ↑ Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A. Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms. International Journal of Radiation Oncology* Biology* Physics. 2012 Aug 1;83(5):1528-33.
- ↑ Amaraneni A, Seth A, Itawi EA, Chandana SR. Oxaliplatin-induced Lhermitte sign. A case report and review of literature. Clinical colorectal cancer. 2014 Dec 1;13(4):257-9.
