Hereditary Hypertension
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Hypertension (HPT) is known to be a complex heterogeneous condition controlled by many genes. The factors that regulate HPT have a strong genetic component, but the precise genes involved in HTN development are not well known. The drug therapy available for HPT do not always prevent the occurrence of high BP.
- 18 genotype/phenotype groups have been found to be linked nearly 1/2 of the primary HPT populations, giving a pathway to discover treatment/prevention better individual primary HPT treatments.[1]
- Novel drug treatment approaches are needed that use this genetic approach and personalized medicine.[2]
Controlling Factors[edit | edit source]
HPT is controlled by complex, not well understood genetic, and epigenetic mechanisms, working through both heritable and environmental factors. The regulatory control mechanisms of HPT is regulated complicated molecular and pathophysiological systems, suggesting that genetic determinants and epigenetic factors control our gene regulation, expression, and function, which in turn influence our vulnerability to the development of HPT.
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References[edit | edit source]
- ↑ Manosroi W, Williams GH. Genetics of human primary hypertension: focus on hormonal mechanisms. Endocrine reviews. 2019 Jun;40(3):825-56.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936319/ (7.5.2024)
- ↑ Pandey KN. Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction. Hypertension. 2024 Mar 28.Available:https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.124.22072 (accessed 7.5.2024)
