Enteropathic Spondylitis: Difference between revisions
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<div class="editorbox"> '''Original Editor '''- [[User:Lucinda hampton|Lucinda hampton]] '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div> | <div class="editorbox"> '''Original Editor '''- [[User:Lucinda hampton|Lucinda hampton]] '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div> | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
== Introduction == | == Introduction == | ||
Enteropathic spondylitis, or | [[File:Body complications.jpg|right|frameless|482x482px]] | ||
Enteropathic spondylitis, or EA, is a form of chronic, inflammatory [[arthritis]] associated with the occurrence of an inflammatory bowel disease ([[Irritable Bowel Syndrome|IBD]]), the two best-known types of which are ulcerative colitis and [[Crohn's Disease|Crohn’s disease]]. | |||
* About one in five people with Crohn’s or ulcerative colitis will develop enteropathic arthritis. | * About one in five people with Crohn’s or ulcerative colitis will develop enteropathic arthritis. | ||
* The most common areas affected by EnA are the peripheral (limb) joints and, in some cases, the entire spine can become involved, as well<ref>SAA [https://spondylitis.org/about-spondylitis/types-of-spondylitis/enteropathic-arthritis/ Enteropathic spondylitis] Available from:https://spondylitis.org/about-spondylitis/types-of-spondylitis/enteropathic-arthritis/ (last accessed 3.7.2020)</ref>. | * The most common areas affected by EnA are the peripheral (limb) joints and, in some cases, the entire spine can become involved, as well<ref>SAA [https://spondylitis.org/about-spondylitis/types-of-spondylitis/enteropathic-arthritis/ Enteropathic spondylitis] Available from:https://spondylitis.org/about-spondylitis/types-of-spondylitis/enteropathic-arthritis/ (last accessed 3.7.2020)</ref>. | ||
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== Mechanism of Injury / Pathological Process == | == Mechanism of Injury / Pathological Process == | ||
* The pathogenesis of EA is not fully understood - observationally joint inflammation occurs in genetically predisposed subjects with bacterial gut infections (providing important evidence for a possible relationship between inflammation of the gut mucosa and arthritis). | |||
* More than two-third of patients with SpA (spondyloarthritis) show microscopic inflammatory changes of gut mucosa without clinical signs of gastrointestinal disease. | |||
* Current theories prepose that genetically predisposed subjects have an aberrant migration of intestinal lymphocytes or macrophages from inflamed gut mucosa to joints. | |||
* A dysfunctional interaction between the mucosal immune system and gut bacteria could result in an abnormal state of immunological tolerance toward flora by alterations in mucosal effector cells or by affecting regulatory cells.<ref>Peluso R, Di Minno MN, Iervolino S, Manguso F, Tramontano G, Ambrosino P, Esposito C, Scalera A, Castiglione F, Scarpa R. [https://www.hindawi.com/journals/jir/2013/631408/ Enteropathic spondyloarthritis: from diagnosis to treatment.] Clinical and Developmental Immunology. 2013 Jan 1;2013.Available from:https://www.hindawi.com/journals/jir/2013/631408/ (last accessed 3.7.2020)</ref> | |||
== Clinical Presentation == | == Clinical Presentation == | ||
Revision as of 07:28, 3 July 2020
Original Editor - Lucinda hampton Top Contributors - Lucinda hampton, Rachael Lowe, Admin, Kim Jackson and Kirenga Bamurange Liliane
Introduction[edit | edit source]
Enteropathic spondylitis, or EA, is a form of chronic, inflammatory arthritis associated with the occurrence of an inflammatory bowel disease (IBD), the two best-known types of which are ulcerative colitis and Crohn’s disease.
- About one in five people with Crohn’s or ulcerative colitis will develop enteropathic arthritis.
- The most common areas affected by EnA are the peripheral (limb) joints and, in some cases, the entire spine can become involved, as well[1].
Clinically Relevant Anatomy[edit | edit source]
add text here relating to clinically relevant anatomy of the condition
Mechanism of Injury / Pathological Process[edit | edit source]
- The pathogenesis of EA is not fully understood - observationally joint inflammation occurs in genetically predisposed subjects with bacterial gut infections (providing important evidence for a possible relationship between inflammation of the gut mucosa and arthritis).
- More than two-third of patients with SpA (spondyloarthritis) show microscopic inflammatory changes of gut mucosa without clinical signs of gastrointestinal disease.
- Current theories prepose that genetically predisposed subjects have an aberrant migration of intestinal lymphocytes or macrophages from inflamed gut mucosa to joints.
- A dysfunctional interaction between the mucosal immune system and gut bacteria could result in an abnormal state of immunological tolerance toward flora by alterations in mucosal effector cells or by affecting regulatory cells.[2]
Clinical Presentation[edit | edit source]
add text here relating to the clinical presentation of the condition
Diagnostic Procedures[edit | edit source]
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Outcome Measures[edit | edit source]
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Management / Interventions[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Key Evidence[edit | edit source]
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Resources[edit | edit source]
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Case Studies[edit | edit source]
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References[edit | edit source]
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- ↑ SAA Enteropathic spondylitis Available from:https://spondylitis.org/about-spondylitis/types-of-spondylitis/enteropathic-arthritis/ (last accessed 3.7.2020)
- ↑ Peluso R, Di Minno MN, Iervolino S, Manguso F, Tramontano G, Ambrosino P, Esposito C, Scalera A, Castiglione F, Scarpa R. Enteropathic spondyloarthritis: from diagnosis to treatment. Clinical and Developmental Immunology. 2013 Jan 1;2013.Available from:https://www.hindawi.com/journals/jir/2013/631408/ (last accessed 3.7.2020)
