Cryoglobulinemia
Original Editor - User Name Temitope Olowoyeye
Top Contributors - Temitope Olowoyeye, Kirenga Bamurange Liliane and Vidya Acharya
Introduction[edit | edit source]
Cryoglobulinemia is an autoimune disorder that is characterised by the persistent presence of a cryoglobulin (Igs) in the serum.[1] [2] Cryoglobulins are proteins that precipitate from an individual’s serum or plasma at temperatures lower than 37 °C, leading to cryoprecipitate. They can be a mixture of immunoglobulin (Ig) and complement components or immunoglobulins alone. Cryoglobulins, which accumulate in blood vessels, can cause endothelial injury and end-organ damage, resulting in cryoglobulinemia.[2]The disease mainly affects small to medium-sized blood vessels[3] and causes vasculitis, which leads to a systemic inflammatory syndrome characterised by fatigue, arthralgia, purpura, neuropathy, and glomerulonephritis [1]
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References[edit | edit source]
- ↑ 1.0 1.1 Naciri Bennani H, Banza AT, Terrec F, Noble J, Jouve T, Motte L, Malvezzi P, Rostaing L. Cryoglobulinemia and double‐filtration plasmapheresis: Personal experience and literature review. Therapeutic Apheresis and Dialysis. 2023 Feb;27(1):159-69.
- ↑ 2.0 2.1 Bhandari J, Awais M, Aeddula NR. Cryoglobulinemia.reasure Island (FL): StatPearls Publishing; 2023 Jan-.
- ↑ Muchtar E, Magen H, Gertz MA. How I treat cryoglobulinemia. Blood, The Journal of the American Society of Hematology. 2017 Jan 19;129(3):289-98.
