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<div class="editorbox"> '''Original Editor '''- [[User:Elaine Lonnemann|Elaine Lonnemann]] '''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}}</div>
<div class="noeditbox">Welcome to [[Pathophysiology of Complex Patient Problems|PT 635 Pathophysiology of Complex Patient Problems]] This is a wiki created by and for the students in the School of Physical Therapy at Bellarmine University in Louisville KY. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!</div><div class="editorbox">
'''Original Editors '''- [[Pathophysiology of Complex Patient Problems|Students from Bellarmine University's&nbsp;Pathophysiology of Complex Patient Problems project.]]  
== Introduction ==
[[File:Cervix.jpeg|right|frameless]]
Cervicitis is inflammation of the cervix, the donut-shaped opening that connects the vagina to the uterus. It can be acute or chronic; with chronic occurring due to inadequate treatment or recurrent inflammation<ref name="Singh">Singh N, Arora A. An Extreme Case of Chronic Cervicitis Mimicking Cervical Cancer and Causing Third-Degree Prolapse. Journal Of Gynecologic Surgery [serial online]. December 2014;30(6):380-382. Available from: Academic Search Complete, Ipswich, MA. Accessed February 23, 2017.</ref> Non-specific cervicitis is the most common; meaning that it is unrelated to an STI like chlamydia or gonorrhea&nbsp;<ref name="Pollett et al">Pollett S, Calderon M, Heitzinger K, Solari V, Montano S, Zunt J. Prevalence and predictors of cervicitis in female sex workers in Peru: an observational study. BMC Infectious Diseases [serial online]. April 30, 2013;13:195. Available from: MEDLINE, Ipswich, MA. Accessed February 23, 2017.</ref> A single instance or acute cervicitis is usually due to an infection like chlamydia or gonorrhea, while chronic is typically due to a non-infectious source<ref name="Efosa et al">Efosa O, Uwadiegwu A. Cytopathological Examination and Epidemiological Study of Cervicitis in Commercial Sex Workers (Csws) in Coal City (Enugu), Nigeria. Ethiopian Journal Of Health Sciences [serial online]. July 2015;25(3):225-230. Available from: Academic Search Complete, Ipswich, MA. Accessed April 4, 2017.</ref> If left untreated cervicitis can lead to pelvic inflammatory disease<ref name="Pollett et al" />


'''Top Contributors''' - {{Special:Contributors/{{FULLPAGENAME}}}} &nbsp;
== Etiology ==
</div>
The etiology is broadly classified into infectious and non-infectious.
== Definition/Description  ==


*Cervicitis is defined as the inflammatory response of the cervix to a particular stimuli<ref name="Singh">Singh N, Arora A. An Extreme Case of Chronic Cervicitis Mimicking Cervical Cancer and Causing Third-Degree Prolapse. Journal Of Gynecologic Surgery [serial online]. December 2014;30(6):380-382. Available from: Academic Search Complete, Ipswich, MA. Accessed February 23, 2017.</ref>
# Infectious agents include Neisseria gonorrhea, Chlamydia trachomatis, and less commonly, herpes simplex, Trichomonas vaginalis, and Mycoplasma genitalium.  
*Can be acute or chronic; with chronic occurring due to inadequate treatment or recurrent inflammation<ref name="Singh" />
# Non-infectious causes include mechanical and chemical irritants. Surgical instruments or foreign objects like pessaries, condoms, diaphragms, cervical caps, or tampons can cause mechanical trauma. Chemical irritants cause allergic reactions and include soaps, laundry products, spermicides, latex, vaginal douches, and contraceptive creams.<ref name=":0">Iqbal U, Wills C. Cervicitis. [Updated 2022 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK562193/ (accessed 12.5.2022)</ref>
*Non-specific cervicitis is the most common; meaning that it is unrelated to an STI like chlamydia or gonorrhea&nbsp;<ref name="Pollett et al">Pollett S, Calderon M, Heitzinger K, Solari V, Montano S, Zunt J. Prevalence and predictors of cervicitis in female sex workers in Peru: an observational study. BMC Infectious Diseases [serial online]. April 30, 2013;13:195. Available from: MEDLINE, Ipswich, MA. Accessed February 23, 2017.</ref>
*A single instance or acute cervicitis is usually due to an infection like chlamydia or gonorrhea, while chronic is typically due to a non-infectious source<ref name="Efosa et al">Efosa O, Uwadiegwu A. Cytopathological Examination and Epidemiological Study of Cervicitis in Commercial Sex Workers (Csws) in Coal City (Enugu), Nigeria. Ethiopian Journal Of Health Sciences [serial online]. July 2015;25(3):225-230. Available from: Academic Search Complete, Ipswich, MA. Accessed April 4, 2017.</ref>
*If left untreated cervicitis can lead to pelvic inflammatory disease<ref name="Pollett et al" />


&nbsp;<br>
== Epidemiology ==
The exact prevalence of cervicitis is difficult to determine as there is a lack of a standard definition and variation by population. Sexual activity is the main risk factor for the infectious causes with it possibly affecting about 30%-40% of the patients seen in sexually transmitted infection (STI) clinics.


== Prevalence  ==
* The highest incidence is in sexually active women aged 15 to 24.
 
* It is more common in human immunodeficiency virus (HIV) positive women, with an estimate of 7400 per 100,000 women diagnosed with HIV<ref name=":0" />.<br>
Cervicitis is currently rarely reported to epidemiologists making true numbers for prevalence roughly estimated from about 8%-40%&nbsp;<ref name="Singh" />
 
*About 61% of cervicitis cases are of unknown etiology&nbsp;<ref name="Taylor">Taylor S, Lensing S, Lee J, et al. Prevalence and treatment outcome of cervicitis of unknown etiology. Sexually Transmitted Diseases [serial online]. May 2013;40(5):379-385. Available from: CINAHL with Full Text, Ipswich, MA. Accessed February 23, 2017.</ref><br><br>


== Characteristics/Clinical Presentation  ==
== Characteristics/Clinical Presentation  ==
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*If symptomatic, person may experience vaginal discharge, dyspareunia, intermenstrual bleeding, or postcoital bleeding&nbsp;<ref name="Singh" />  
*If symptomatic, person may experience vaginal discharge, dyspareunia, intermenstrual bleeding, or postcoital bleeding&nbsp;<ref name="Singh" />  
*Occasionally will present in an abnormal fashion, such as a cervical growth or uterovaginal prolapse, but that is rare and usually due to delayed or no treatment&nbsp;<ref name="Singh" /><br><br>
*Occasionally will present in an abnormal fashion, such as a cervical growth or uterovaginal prolapse, but that is rare and usually due to delayed or no treatment&nbsp;<ref name="Singh" />


== Associated Co-morbidities  ==
== Associated Co-morbidities  ==


In many cases, Mycoplasma Genitalium bacteria occurs simultaneously with cervicitis <ref name="Taylor" /><br><br>
In many cases, Mycoplasma Genitalium bacteria occurs simultaneously with cervicitis. Gonorrhea and chlamydia is also commonly found in correlation with cervicitis&nbsp;<ref name="Taylor">Taylor S, Lensing S, Lee J, et al. Prevalence and treatment outcome of cervicitis of unknown etiology. Sexually Transmitted Diseases [serial online]. May 2013;40(5):379-385. Available from: CINAHL with Full Text, Ipswich, MA. Accessed February 23, 2017.</ref><ref name="Sheeder et al">Sheeder J, Stevens-Simon C, Lezotte D, Glazner J, Scott S. Cervicitis: To Treat or Not To Treat? The Role of Patient Preferences and Decision Analysis. Journal Of Adolescent Health [serial online]. December 2006;39(6):887-892. Available from: PsycINFO, Ipswich, MA. Accessed March 22, 2017</ref> Untreated, cervicitis can lead to pelvic inflammatory disease (PID) <ref name="Sheeder et al" />
 
*Gonorrhea and chlamydia is also commonly found in correlation with cervicitis&nbsp;<ref name="Taylor" /><ref name="Sheeder et al ">Sheeder J, Stevens-Simon C, Lezotte D, Glazner J, Scott S. Cervicitis: To Treat or Not To Treat? The Role of Patient Preferences and Decision Analysis. Journal Of Adolescent Health [serial online]. December 2006;39(6):887-892. Available from: PsycINFO, Ipswich, MA. Accessed March 22, 2017</ref>
 
== Medications  ==
 
Antibiotics are frequently given once cervicitis is found <br><br>
 
*No other medications are usually prescribed to help with this condition<ref name="Liu et al ">Liu C, Zhang Y, Kong S, Tsui I, Yu Y, Han F. Applications and therapeutic actions of complementary and alternative medicine for women with genital infection. Evidence-Based Complementary And Alternative Medicine: Ecam [serial online]. 2014;2014:658624. Available from: MEDLINE, Ipswich, MA. Accessed April 4, 2017.</ref>
 
== Diagnostic Tests/Lab Tests/Lab Values  ==
== Diagnostic Tests/Lab Tests/Lab Values  ==


In order to diagnose a culture is taken to look for mucopurulent discharge <ref name="Lusk et al ">Lusk M, Garden F, Rawlinson W, Naing Z, Cumming R, Konecny P. Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics. Sexually Transmitted Infections [serial online]. May 2016;92(3):175-181. Available from: MEDLINE, Ipswich, MA. Accessed February 23, 2017.</ref><br><br>
In order to diagnose a culture is taken to look for mucopurulent discharge <ref name="Lusk et al">Lusk M, Garden F, Rawlinson W, Naing Z, Cumming R, Konecny P. Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics. Sexually Transmitted Infections [serial online]. May 2016;92(3):175-181. Available from: MEDLINE, Ipswich, MA. Accessed February 23, 2017.</ref> A culture is taken to look for specific bacteria like chlamydia, gonorrhea, or mycoplasma genitalium&nbsp;<ref name="Lusk et al" />
 
== Treatment ==
*A culture is taken to look for specific bacteria like chlamydia, gonorrhea, or mycoplasma genitalium&nbsp;<ref name="Lusk et al " />
Treatment may not be needed for cervicitis if a sexually transmitted infection is not the cause.
 
== Etiology/Causes  ==
 
*Cervicitis can be associated with preterm childbirth and pelvic inflammatory disease<ref name="Lusk et al " />
*Chlamydia, gonorrhea, trichomonas, bacterial vaginosis and mycoplasma genitalium are all seen to contribute to acute, infectious cervicitis&nbsp;<ref name="Lusk et al" />
*Decreased use of condoms with sexual activity are shown to increase the risk for acquiring cervicitis&nbsp;<ref name="Pollett et al " />
*Lower education and multiple sexual partners were also seen to contribute to the condition&nbsp;<ref name="Pollett et al " />
*Cytomegalovirus has recently been shown to lead to cervicitis as well&nbsp;<ref name="Abou">Abou M, Dällenbach P. Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus. BMJ Case Reports [serial online]. April 19, 2013;2013 Available from: MEDLINE, Ipswich, MA. Accessed March 22, 2017.</ref><br><br>
 
== Systemic Involvement  ==
 
Untreated, cervicitis can lead to pelvic inflammatory disease (PID) <ref name="Sheeder et al " /><br>
 
*Postcoital bleeding is also a common occurrence when cervicitis in inadequately or not treated<ref name="Liu et al " />
 
== Medical Management (current best evidence)  ==
 
Best evidence, is currently antibiotic therapies <ref name="Taylor et al " /><br>
 
*Complementary and Alternative Medicine is now being introduced to treat this diagnosis&nbsp;<ref name="Liu et al " />
 
== Physical Therapy Management (current best evidence)  ==
 
*Electrotherapy
*Magnet therapy
*Heat therapy
*Light therapy
*External high frequency calorimetry
*Low frequency pulsed ultrasound therapy
*Iontophoresis
*Shortwave ultrasound combined with intermediate frequency electrical stimulation
*Ozone therapy
*Shortwave diathermy<br>
 
== Differential Diagnosis  ==
 
*Cystic cervicitis
*Vaginosis
*Vulva vaginitis
*Herpes Simplex Virus<br>
 
== Case Reports/ Case Studies  ==
 
Singh N, Arora A. An Extreme Case of Chronic Cervicitis Mimicking Cervical Cancer and Causing Third-Degree Prolapse. Journal Of Gynecologic Surgery [serial online]. December 2014;30(6):380-382. Available from: Academic Search Complete, Ipswich, MA. Accessed February 23, 2017.
 
(case studies should be added on new pages using the [[Template:Case Study|case study template]])<br>


== Resources <br>  ==
If an infection is suspected, the main goal of treatment is to eliminate the infection and prevent it from spreading to the uterus and fallopian tubes, or if pregnant, to the baby. Depending on what organism is causing the infection the following may be prescribed:


https://www.plannedparenthood.org
* [[Antibiotics]]
* Antifungal medications
* Antiviral medications


== Recent Related Research (from [http://www.ncbi.nlm.nih.gov/pubmed/ Pubmed])  ==
The partner may be treated to make sure client does not get infected again. Sex should not be resumed till client and partner have finished treatment. Cervicitis increases the amount of virus that is shed from the cervix,  increasing the chances of infecting a partner.  


see tutorial on [[Adding PubMed Feed|Adding PubMed Feed]]
Nondrug treatments like douches or yogurt-based therapy do not work for cervicitis and may actually worsen symptoms. They are not recommended<ref>Web md Cervicitis Available:https://www.webmd.com/women/guide/cervicitis (accessed 12.5.2022)</ref>.
<div class="researchbox">
<rss>addfeedhere|charset=UTF-8|short|max=10</rss>
</div>  
== References  ==


see [[Adding References|adding references tutorial]].
== References ==


<references />  
<references />  


<br>
<br>  


[[Category:Bellarmine_Student_Project]]
[[Category:Bellarmine_Student_Project]]
[[Category:Womens Health]]
[[Category:Global Health]]
[[Category:Communicable Diseases]]

Latest revision as of 23:44, 13 May 2022

Original Editor - Elaine Lonnemann Top Contributors - Rachael Lewin, Victoria Loving, Lucinda hampton, Elaine Lonnemann, Kim Jackson, 127.0.0.1 and WikiSysop

Introduction[edit | edit source]

Cervix.jpeg

Cervicitis is inflammation of the cervix, the donut-shaped opening that connects the vagina to the uterus. It can be acute or chronic; with chronic occurring due to inadequate treatment or recurrent inflammation[1] Non-specific cervicitis is the most common; meaning that it is unrelated to an STI like chlamydia or gonorrhea [2] A single instance or acute cervicitis is usually due to an infection like chlamydia or gonorrhea, while chronic is typically due to a non-infectious source[3] If left untreated cervicitis can lead to pelvic inflammatory disease[2]

Etiology[edit | edit source]

The etiology is broadly classified into infectious and non-infectious.

  1. Infectious agents include Neisseria gonorrhea, Chlamydia trachomatis, and less commonly, herpes simplex, Trichomonas vaginalis, and Mycoplasma genitalium.
  2. Non-infectious causes include mechanical and chemical irritants. Surgical instruments or foreign objects like pessaries, condoms, diaphragms, cervical caps, or tampons can cause mechanical trauma. Chemical irritants cause allergic reactions and include soaps, laundry products, spermicides, latex, vaginal douches, and contraceptive creams.[4]

Epidemiology[edit | edit source]

The exact prevalence of cervicitis is difficult to determine as there is a lack of a standard definition and variation by population. Sexual activity is the main risk factor for the infectious causes with it possibly affecting about 30%-40% of the patients seen in sexually transmitted infection (STI) clinics.

  • The highest incidence is in sexually active women aged 15 to 24.
  • It is more common in human immunodeficiency virus (HIV) positive women, with an estimate of 7400 per 100,000 women diagnosed with HIV[4].

Characteristics/Clinical Presentation[edit | edit source]

In many case cervicitis remains asymptomatic

  • If symptomatic, person may experience vaginal discharge, dyspareunia, intermenstrual bleeding, or postcoital bleeding [1]
  • Occasionally will present in an abnormal fashion, such as a cervical growth or uterovaginal prolapse, but that is rare and usually due to delayed or no treatment [1]

Associated Co-morbidities[edit | edit source]

In many cases, Mycoplasma Genitalium bacteria occurs simultaneously with cervicitis. Gonorrhea and chlamydia is also commonly found in correlation with cervicitis [5][6] Untreated, cervicitis can lead to pelvic inflammatory disease (PID) [6]

Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]

In order to diagnose a culture is taken to look for mucopurulent discharge [7] A culture is taken to look for specific bacteria like chlamydia, gonorrhea, or mycoplasma genitalium [7]

Treatment[edit | edit source]

Treatment may not be needed for cervicitis if a sexually transmitted infection is not the cause.

If an infection is suspected, the main goal of treatment is to eliminate the infection and prevent it from spreading to the uterus and fallopian tubes, or if pregnant, to the baby. Depending on what organism is causing the infection the following may be prescribed:

  • Antibiotics
  • Antifungal medications
  • Antiviral medications

The partner may be treated to make sure client does not get infected again. Sex should not be resumed till client and partner have finished treatment. Cervicitis increases the amount of virus that is shed from the cervix, increasing the chances of infecting a partner.

Nondrug treatments like douches or yogurt-based therapy do not work for cervicitis and may actually worsen symptoms. They are not recommended[8].

References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 Singh N, Arora A. An Extreme Case of Chronic Cervicitis Mimicking Cervical Cancer and Causing Third-Degree Prolapse. Journal Of Gynecologic Surgery [serial online]. December 2014;30(6):380-382. Available from: Academic Search Complete, Ipswich, MA. Accessed February 23, 2017.
  2. ↑ 2.0 2.1 Pollett S, Calderon M, Heitzinger K, Solari V, Montano S, Zunt J. Prevalence and predictors of cervicitis in female sex workers in Peru: an observational study. BMC Infectious Diseases [serial online]. April 30, 2013;13:195. Available from: MEDLINE, Ipswich, MA. Accessed February 23, 2017.
  3. ↑ Efosa O, Uwadiegwu A. Cytopathological Examination and Epidemiological Study of Cervicitis in Commercial Sex Workers (Csws) in Coal City (Enugu), Nigeria. Ethiopian Journal Of Health Sciences [serial online]. July 2015;25(3):225-230. Available from: Academic Search Complete, Ipswich, MA. Accessed April 4, 2017.
  4. ↑ 4.0 4.1 Iqbal U, Wills C. Cervicitis. [Updated 2022 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK562193/ (accessed 12.5.2022)
  5. ↑ Taylor S, Lensing S, Lee J, et al. Prevalence and treatment outcome of cervicitis of unknown etiology. Sexually Transmitted Diseases [serial online]. May 2013;40(5):379-385. Available from: CINAHL with Full Text, Ipswich, MA. Accessed February 23, 2017.
  6. ↑ 6.0 6.1 Sheeder J, Stevens-Simon C, Lezotte D, Glazner J, Scott S. Cervicitis: To Treat or Not To Treat? The Role of Patient Preferences and Decision Analysis. Journal Of Adolescent Health [serial online]. December 2006;39(6):887-892. Available from: PsycINFO, Ipswich, MA. Accessed March 22, 2017
  7. ↑ 7.0 7.1 Lusk M, Garden F, Rawlinson W, Naing Z, Cumming R, Konecny P. Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics. Sexually Transmitted Infections [serial online]. May 2016;92(3):175-181. Available from: MEDLINE, Ipswich, MA. Accessed February 23, 2017.
  8. ↑ Web md Cervicitis Available:https://www.webmd.com/women/guide/cervicitis (accessed 12.5.2022)


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