Bed Rest And Skeletal Muscle
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Muscle atrophy and muscle strength losses very rapidly occur with prolonged bed rest. Hospitalization of ≤5 days, being disuse/immobilization/ or prolonged time in the supine position bed, causes significant decreases in muscle mass and size. This in turn leads to functional decline.
- There is a logarithmic disuse-induced loss of strength and muscle atrophy.
- In the first 2 wks of bed rest, muscle strength decline is much faster than muscle atrophy.
Bed Rest: Metabolic Muscle Changes[edit | edit source]
The main matabolic musclular changes are insulin sensitivity and metabolic flexibility decrease in response to bed rest.
- Muscle glycogen build-up in bed rest decreases insulin sensitivity and storage of glycogen
- Lipid overload in muscles leads to lipotoxicity causing inflammation develop during bed rest
- Muscle metabolism from changes from fatty acid to glucose oxidation
- With long term bed rest internal mitochondrial alterations occur
Sub Heading 3[edit | edit source]
Exercise interventions significantly attenuated loss of muscle mass. This was the findings of a recent study.
The exercise interventions included resistive exercise (RE), resistive vibration exercise (RVE), flywheel resistive exercise, treadmill exercise with lower body negative pressure (LBNP) and a zero-gravity locomotion simulator (ZLS).
With exercise intervention, high rates of bone loss were still observed.[1]
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References[edit | edit source]
- ↑ Konda NN, Karri RS, Winnard A, Nasser M, Evetts S, Boudreau E, Caplan N, Gradwell D, Velho RM. A comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss. npj Microgravity. 2019 May 8;5(1):12.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506471/ (accessed 16.4.2024)