Bed Rest And Skeletal Muscle: Difference between revisions
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== Introduction == | == Introduction == | ||
Muscle atrophy and muscle strength losses very rapidly occur with prolonged bed rest. Hospitalization of ≤5 days, incorporating disuse/immobilization/ or prolonged time in the supine position bed causes significant decreases in muscle mass and size. This in turn leads to functional decline. | |||
== | There is a logarithmic disuse-induced loss of strength and muscle atrophy. | ||
In the first 2 wks of bed rest, muscle strength decline is much faster than muscle atrophy. | |||
== Bed Rest: Metabolic Muscle Changes == | |||
* Muscle glycogen build-up in bed rest decreases insulin sensitivity and storage of glycogen | |||
* Lipid overload in muscles leads to lipotoxicity causing inflammation develop during bed rest | |||
* Muscle metabolism from changes from fatty acid to glucose oxidation | |||
* With long term bed rest internal mitochondrial alterations occur | |||
== Sub Heading 3 == | == Sub Heading 3 == |
Revision as of 08:23, 16 April 2024
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton
Introduction[edit | edit source]
Muscle atrophy and muscle strength losses very rapidly occur with prolonged bed rest. Hospitalization of ≤5 days, incorporating disuse/immobilization/ or prolonged time in the supine position bed causes significant decreases in muscle mass and size. This in turn leads to functional decline.
There is a logarithmic disuse-induced loss of strength and muscle atrophy.
In the first 2 wks of bed rest, muscle strength decline is much faster than muscle atrophy.
Bed Rest: Metabolic Muscle Changes[edit | edit source]
- Muscle glycogen build-up in bed rest decreases insulin sensitivity and storage of glycogen
- Lipid overload in muscles leads to lipotoxicity causing inflammation develop during bed rest
- Muscle metabolism from changes from fatty acid to glucose oxidation
- With long term bed rest internal mitochondrial alterations occur
Sub Heading 3[edit | edit source]
Resources[edit | edit source]
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