Bed Rest And Skeletal Muscle

Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton  

Introduction

Muscle atrophy and muscle strength losses very rapidly occur with prolonged bed rest. Hospitalization of ≤5 days, incorporating disuse/immobilization/ or prolonged time in the supine position bed causes significant decreases in muscle mass and size. This in turn leads to functional decline.

There is a logarithmic disuse-induced loss of strength and muscle atrophy.

In the first 2 wks of bed rest, muscle strength decline is much faster than muscle atrophy.

Bed Rest: Metabolic Muscle Changes

• Muscle glycogen build-up in bed rest decreases insulin sensitivity and storage of glycogen
• Lipid overload in muscles leads to lipotoxicity causing inflammation develop during bed rest
• Muscle metabolism from changes from fatty acid to glucose oxidation
• With long term bed rest internal mitochondrial alterations occur

Resources

• bulleted list
• x

or

1. numbered list
2. x