Sleep Disorders and Cancer
Original Editor - Sehriban Ozmen
Top Contributors - Sehriban Ozmen, Kapil Narale, Rujuta Naik and Lucinda hampton
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Introduction[edit | edit source]
There is a bidirectional correlation between cancer and sleep disorders. This means that having a sleep disorder may increase the risk of developing cancer in the future, and those with cancer are likely to experience sleep disorders during diagnosis, treatment and even ten years of survivorship. [1] [2] On this page, this correlation will be detailed for various sleep and cancer diseases. Underlying causes as well as preventive and curative treatment methods will also be included since sleep disorders decrease the quality of life by affecting the physical and mental health of people with cancer/tumors [1] [2].
Underlying Mechanism[edit | edit source]
Sleep disorders in people with cancer are associated with the following: [3]
- Activation of the inflammatory response (even during chemotherapy: Cytokines activate microglia, thus astrocyte neurotoxic reaction.
- Production of interleukins by tumours: Interleukin-1 beta (IL-1 β) inhibits REM (rapid eye movement) sleep and affects the neurotransmitters involved in sleep (adenosine, prostaglandins, nitric oxide, GABA). Interleukin-6 (IL-6) produced in high quantities in breast, lung, liver and prostate cancer also seems to reduce REM sleep and increase slow-wave sleep.
- The factors activating the hypothalamic orexin (also called hypocretin) neurons: Ghrelin (correlated with an increase in tumour), leptin (produced in breast, prostate, pancreas, ovary, lung and colorectal cancer and involved in the proliferation of cancer cells), a reduction in pH, hypoglycemia and some amino acids.
- Changes in the serotonergic, dopaminergic, GABAergic and noradrenergic circuits induced by tumours
Sleep Disorders As a Risk Factor in Cancer[edit | edit source]
Cancer Induced Sleep Disorders[edit | edit source]
Treatment Options[edit | edit source]
Resources[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 Mogavero MP, DelRosso LM, Fanfulla F, Bruni O, Ferri R. Sleep disorders and cancer: State of the art and future perspectives. Sleep Medicine Reviews. 2021 Apr 1;56:101409.
- ↑ 2.0 2.1 Büttner-Teleagă A, Kim YT, Osel T, Richter K. Sleep disorders in cancer—a systematic review. International journal of environmental research and public health. 2021 Nov 7;18(21):11696.
- ↑ Walker WH, Borniger JC. Molecular mechanisms of cancer-induced sleep disruption. International journal of molecular sciences. 2019 Jun 6;20(11):2780.
