Inflammaging
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton and Tolulope Adeniji
Introduction[edit | edit source]
Old age is typified by an atypical low-grade, chronic, and "sterile" inflammatory state, now termed as "inflammaging." These changes are associated with a loss of physical and immune resilience, amplifying the risk of being malnourished and frail and significantly contributes to the pathogenesis of many age-related diseases and to the progression of the ageing process.[1][2]
This 2 minute video gives a simple introduction to the topic.
The Role Diet Plays[edit | edit source]
The kind of diet adhered to affects inflammation directly. Healthy diets that include a higher intake of whole grains, vegetables and fruits, nuts and fish appear to counteract the low grade age-related inflammation, for example the Mediterranean diet. Such diets are associated with lower concentrations of inflammatory mediators, like C-reactive protein (CRP) and Tumor Necrosis Factor-α (TNF-α), that are hallmarks of inflammaging.
An emerging area of research is the microbiome-ageing interaction. Studies show dysbiosis plays a role in sub-optimal metabolism, immune function and brain function, which all contribute to the poor health and impaired well-being associated with ageing. Modulation of the gut microbiota is showing promising results in some disorders[1].
Contributors to inflammaging: adipose tissue and dietary fat.
- Excessive intake of lipids can modify the gut microbiota contributing to metabolic endotoxemia, whilst omega 3 fatty acids (in eg fish oils) seem to attenuate this change.
- The aging-related increase and redistribution of body fat stand (higher fat content) allows the infiltration of M1 macrophages and T lymphocytes. These immune cells, and the adipocytes themselves, release cytokines and chemokines increasing the inflammatory profile.[4]
Sub Heading 3[edit | edit source]
It is known that decreased physical activity has a detrimental role in muscle quality, and inappropriate nutritional habits favor the acceleration of immunosenescence and inflammaging (129).
Physical activity can alter the systemic inflammation of older adults regardless of their level of intensity, reducing blood fibrinogen and C-reactive protein levels. It should be noted that all significant influences on fibrinogen and C-reactive protein by displacement of different physical activity behaviors remained after adjustment for metabolic risk status among participants.
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References[edit | edit source]
- ↑ 1.0 1.1 Di Giosia P, Stamerra CA, Giorgini P, Jamialahamdi T, Butler AE, Sahebkar A. The role of nutrition in inflammaging. Ageing Research Reviews. 2022 Feb 24:101596. Available:https://pubmed.ncbi.nlm.nih.gov/35219904/ (accessed 29.7.2022)
- ↑ Padilha de Lima A, Macedo Rogero M, Araujo Viel T, Garay-Malpartida HM, Aprahamian I, Ribeiro SM. Interplay between Inflammaging, Frailty and Nutrition in Covid-19: Preventive and Adjuvant Treatment Perspectives. The journal of nutrition, health & aging. 2021 Dec 28:1-0. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713542/ (accessed 29.7.2022)
- ↑ LIV Health. What is Inflammaging. Available from: https://www.youtube.com/watch?app=desktop&v=aDEAXa9JSBs [last accessed 29/7/2022]
- ↑ Padilha de Lima A, Macedo Rogero M, Araujo Viel T, Garay-Malpartida HM, Aprahamian I, Ribeiro SM. Interplay between Inflammaging, Frailty and Nutrition in Covid-19: Preventive and Adjuvant Treatment Perspectives. The journal of nutrition, health & aging. 2021 Dec 28:1-0. Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713542/ (accessed 29.7.2022)
