Parkinsonism

Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton, Aminat Abolade and Mason Trauger  

Introduction[edit | edit source]

Parkinsonism is a constellation of signs and symptoms that are characteristically observed in Parkinson’s disease (PD), but that are not necessarily due to PD[1]. Parkinsonism is the primary type of hypokinetic movement disorder, manifesting as rigidity, tremors, and bradykinesia.

Early in the disease process, it is often hard to know whether a person has idiopathic Parkinson’s disease or a syndrome that mimics it. These syndromes tend to progress more rapidly than Parkinson’s, present with additional symptoms such as early falling, dementia or hallucinations, and do not respond or respond only for a short time to levodopa therapy[2].

Parkinsonism syndromes includes idiopathic Parkinson disease (PD), Parkinson-plus Syndromes, and vascular Parkinsonism (VaP), among other rarer causes of parkinsonism.[3][4]

Following are descriptions of some of the most common Parkinsonism disorders, known as Parkinson Plus Synsromes. Remember many people will not exhibit the cardinal symptoms necessary for a diagnosis of a specific disorder and will simply be labeled “parkinsonism”. For these people a definite diagnosis will only come if the family requests a brain autopsy at time of death[2].

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References[edit | edit source]

  1. Singer HS, Mink J, Gilbert DL, Jankovic J. Movement disorders in childhood. Academic Press; 2015 Oct 27. Available:https://www.sciencedirect.com/science/article/pii/B9780124115736000152 (accessed 17.3.2022)
  2. 2.0 2.1 Parkinson org PD vs parkinsonism Available: https://www.parkinson.org/sites/default/files/attachments/Parkinsons-Disease-vs-Parkinsonisms.pdf (accessed 17.3.2022)
  3. Shrimanker I, Tadi P, Sánchez-Manso JC Sept 2021. Parkinsonism.Available: https://www.ncbi.nlm.nih.gov/books/NBK542224/(accessed 17.3.2022)
  4. Williams DR, Litvan I. Parkinsonian syndromes. Continuum: lifelong learning in neurology. 2013 Oct;19(5 Movement Disorders):1189.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234134/ (accessed 17.3.2022)