Wallerian Degeneration

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Top Contributors - Anthonia Abraham, Kim Jackson, Cindy John-Chu and Lucinda hampton

Clinically Relevant Anatomy[edit | edit source]

Wallerian degeneration is an active process of retrograde degeneration of an axon that is as a result of a nerve lesion.

Mechanism of Injury / Pathological Process[edit | edit source]

The pathological process of a walleroian degeneration is in 4 stages;

  • Axon Degeneration; Within approximately 30 minutes of injury, there is a separation of the proximal and distal ends of the nerve. After a short latency period of the transected membranes are sealed until degeneration. This is marked by the formation of axonal spheroids. The degeneration process is usually slower in the CNS and shorter in PNS
  • mylien Clerance
  • regeneration


Clinical Presentation[edit | edit source]

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Diagnostic Procedures[edit | edit source]

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Outcome Measures[edit | edit source]

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Management / Interventions[edit | edit source]

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Differential Diagnosis[edit | edit source]

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Resources[edit | edit source]

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References[edit | edit source]