Fertility: Difference between revisions

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* Unexplained – 28 percent
* Unexplained – 28 percent
* Male factor (hypogonadism, post-testicular defects, seminiferous tubule dysfunction) – 26 percent
* Male factor (hypogonadism, post-testicular defects, seminiferous tubule dysfunction) – 26 percent
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!Issues
!Information
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|Ovary
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* Ovulatory disorders: Infrequent ovulation (oligoovulation) or absent ovulation (anovulation) results in infertility because an oocyte is not available every month for fertilization
* Oocyte aging: The decrease in fecundability with aging is likely due to a decline in both the quantity and quality of the oocytes<ref>Faddy MJ, Gosden RG. Physiology: A mathematical model of follicle dynamics in the human ovary. Human Reproduction. 1995 Apr 1;10(4):770-5.</ref>
* Ovarian cysts: can have a negative affect on fertility<ref>Legendre G, Catala L, Morinière C, Lacoeuille C, Boussion F, Sentilhes L, Descamps P. Relationship between ovarian cysts and infertility: what surgery and when?. Fertility and sterility. 2014 Mar 1;101(3):608-14.</ref>
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|Fallopian tube abnormalities / Pelvic adhesions
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* Tubal disease and pelvic adhesions prevent normal transport of the oocyte and sperm through the fallopian tube
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|Uterus
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* Uterine leiomyomata
* Uterine anomalies
* Intrauterine adhesions
* Luteal phase defect
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|Endometerosis
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|Cervical factors
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|Inherited thrombophilia
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|Immune factors
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* Antiphospholipid syndrome
* Antibodies unrelated to APS
* Celiac disease
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|Genetic causes
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|Lifestyle factors
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* See below
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|Unexplained
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Modifiable lifestyle factors affecting fertility
Modifiable lifestyle factors affecting fertility

Revision as of 18:33, 23 May 2019

This article is currently under review and may not be up to date. Please come back soon to see the finished work! (23/05/2019)

Definition[edit | edit source]

The World Health Organization calculated that over 10% of women are affected by infertility and subfertility.[1]

Fertility: refers to the capacity to conceive and produce offspring

Infertility: is the inability to conceive despite frequent coitus. Infertility refers to a state in which the capacity for fertility is diminished, but not necessarily absent

Etiology[edit | edit source]

Pathology affecting fertility[2]

  • Ovulatory dysfunction – 21 percent
  • Tubal damage – 14 percent
  • Endometriosis – 6 percent
  • Coital problems – 6 percent
  • Cervical factor – 3 percent
  • Unexplained – 28 percent
  • Male factor (hypogonadism, post-testicular defects, seminiferous tubule dysfunction) – 26 percent

Modifiable lifestyle factors affecting fertility

Factors affecting fertility Information
Tobacco use
  • has been associated with subfertility
Weight
Exercise
Alcohol intake
Diet
Caffiene
Stress
Environmental factors
Recreational drug use
Sexual behaviour

Management[edit | edit source]

Physiotherapy

Medical Interventions

The following tests are useful in most couples with infertility:[3]

  • Semen analysis to assess male factors.
  • Menstrual history, assessment of luteinizing hormone surge in urine prior to ovulation, and/or luteal phase progesterone level to assess ovulatory function.
  • Hysterosalpingogram or sonohysterogram with a test of tubal patency such as hysterosalpingo-contrast-sonography to assess tubal patency and the uterine cavity.
  • Assessment of ovarian reserve with day 3 serum follicle-stimulating hormone and estradiol levels, anti-Müllerian hormone, and/or antral follicle count.
  • Thyroid-stimulating hormone.

In select couples, the following additional tests may be warranted:

  • Pelvic ultrasound to assess for uterine myomas and ovarian cysts
  • Laparoscopy to identify endometriosis or other pelvic pathology

Resources[edit | edit source]

References[edit | edit source]

  1. World Health Organization. Sexual and reproductive health. Available from https://www.who.int/reproductivehealth/topics/infertility/perspective/en/
  2. Hull MG, Glazener CM, Kelly NJ, Conway DI, Foster PA, Hinton RA, Coulson C, Lambert PA, Watt EM, Desai KM. Population study of causes, treatment, and outcome of infertility. Br Med J (Clin Res Ed). 1985 Dec 14;291(6510):1693-7.
  3. Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile female: a committee opinion. Fertility and sterility. 2012 Aug 1;98(2):302-7.