Extracellular Matrix: Difference between revisions
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== Introduction == | == Introduction == | ||
The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, providing a essential physical scaffolding for the cellular constituents (components of the ECM linking together to form a structurally stable composite). ECM components not only provide a scaffold for the tissue but also give tensile strength and limit overstretch of the organ. The ECM holds water, ensures suitable hydration of the tissue, and participates in a selective barrier to the external environment. The ECM also initiates crucial biochemical and biomechanical cues for tissue morphogenesis, differentiation and homeostasis<ref>Simona Pompili, Giovanni Latella, '''Eugenio Gaudio,''' Roberta Sferra'''and''' Antonella Vetuschi The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.610189/full (accessed 28.6.2022)</ref><ref>Christian Frantz,Kathleen M. Stewart,Valerie M. Weaver The extracellular matrix at a glance Available: https://journals.biologists.com/jcs/article/123/24/4195/31378/The-extracellular-matrix-at-a-glance (accessed 28.7.2022)</ref>. | The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, providing a essential physical scaffolding for the cellular constituents (components of the ECM linking together to form a structurally stable composite). ECM components not only provide a scaffold for the tissue but also give tensile strength and limit overstretch of the organ. The ECM holds water, ensures suitable hydration of the tissue, and participates in a selective barrier to the external environment. The ECM also initiates crucial biochemical and biomechanical cues for tissue morphogenesis, differentiation and homeostasis<ref>Simona Pompili, Giovanni Latella, '''Eugenio Gaudio,''' Roberta Sferra'''and''' Antonella Vetuschi The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.610189/full (accessed 28.6.2022)</ref><ref>Christian Frantz,Kathleen M. Stewart,Valerie M. Weaver The extracellular matrix at a glance Available: https://journals.biologists.com/jcs/article/123/24/4195/31378/The-extracellular-matrix-at-a-glance (accessed 28.7.2022)</ref>. | ||
The role of the extracellular matrix depends on its nature and composition. eg, the matrix may be mineralised in bone to resist compression), dominated by tension resisting fibers in tendon. | |||
In human, the main components of the extracellular matrix are the fibrous elements (e.g. [[collagen]], elastin, reticulin), link proteins (e.g. fibronectin, laminin), and space filling molecules (e.g. [[proteoglycans]], glycosaminoglycans)<ref>Biology on line Extracellular matrix Available: https://www.biologyonline.com/dictionary/extracellular-matrix (accessed 28.6.22)</ref> | |||
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Revision as of 02:51, 28 June 2022
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton and Tolulope Adeniji
Introduction[edit | edit source]
The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, providing a essential physical scaffolding for the cellular constituents (components of the ECM linking together to form a structurally stable composite). ECM components not only provide a scaffold for the tissue but also give tensile strength and limit overstretch of the organ. The ECM holds water, ensures suitable hydration of the tissue, and participates in a selective barrier to the external environment. The ECM also initiates crucial biochemical and biomechanical cues for tissue morphogenesis, differentiation and homeostasis[1][2].
The role of the extracellular matrix depends on its nature and composition. eg, the matrix may be mineralised in bone to resist compression), dominated by tension resisting fibers in tendon.
In human, the main components of the extracellular matrix are the fibrous elements (e.g. collagen, elastin, reticulin), link proteins (e.g. fibronectin, laminin), and space filling molecules (e.g. proteoglycans, glycosaminoglycans)[3]
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References[edit | edit source]
- ↑ Simona Pompili, Giovanni Latella, Eugenio Gaudio, Roberta Sferraand Antonella Vetuschi The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.610189/full (accessed 28.6.2022)
- ↑ Christian Frantz,Kathleen M. Stewart,Valerie M. Weaver The extracellular matrix at a glance Available: https://journals.biologists.com/jcs/article/123/24/4195/31378/The-extracellular-matrix-at-a-glance (accessed 28.7.2022)
- ↑ Biology on line Extracellular matrix Available: https://www.biologyonline.com/dictionary/extracellular-matrix (accessed 28.6.22)
