Liver Function Tests: Difference between revisions
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!'''Alkaline phosphatase (ALP) | !'''Alkaline phosphatase (ALP);''' Normal value: 30–120 IU/l<ref name=":0" /> | ||
|- | |- | ||
|'''Causes of raised ALP''' | |'''Causes of raised ALP:''' | ||
* Physiological | * Physiological | ||
** Women in the third trimester of pregnancy. | ** Women in the third trimester of pregnancy. | ||
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** Metastatic liver disease. | ** Metastatic liver disease. | ||
** Bone disease.<ref name=":1" /> | ** Bone disease.<ref name=":1" /> | ||
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== | !'''Gammaglutamyl transferase (GGT)'''; Normal value: 0 to 30 IU/L<ref name=":0" /> | ||
* | |- | ||
* | |'''Causes of raised GGT:''' | ||
* Hepatobiliary disease (often with other liver enzyme abnormalities). | |||
* Pancreatic disease. | |||
# | * Alcoholism. | ||
# | * Chronic obstructive pulmonary disease. | ||
* Renal failure. | |||
* Diabetes. | |||
* Myocardial infarction. | |||
* Drugs—for example, carbamazepine, phenytoin, and barbiturates.<ref name=":1" /> | |||
|} | |||
{| class="wikitable" | |||
!'''Bilirubin'''; Normal value: 2 to 17 micromoles/L<ref name=":0" /> | |||
|- | |||
|'''Causes of isolated hyperbilirubinemia:''' | |||
* Unconjugated | |||
*# Increased bilirubin production. | |||
*#* Haemolysis. | |||
*#* Ineffective erythropoiesis. | |||
*#* Blood transfusion. | |||
*#* Resorption of haematomas. | |||
*# Decreased hepatic uptake. | |||
*#* Gilbert’s syndrome. | |||
*#* Drugs—for example, rifampicin. | |||
*# Decreased conjugation. | |||
*#* Gilbert’s syndrome. | |||
*#* Criggler-Najjar syndrome. | |||
*#* Physiological jaundice of the newborn. | |||
* Conjugated | |||
*# Dubin-Johnson syndrome. | |||
*# Rotor’s syndrome.<ref name=":1" /> | |||
|} | |||
== References == | == References == |
Revision as of 11:29, 29 November 2020
Introduction[edit | edit source]
Groups of blood tests performed to know the condition of a liver of a patient are known as liver function tests (LFT) or liver panel or hepatic function panel or hepatic panel.[1]
Components of Liver Function Tests[edit | edit source]
Alanine Transaminase (ALT); Normal value: 0-45 IU/L
Aspartate Transaminase (AST); Normal value: 0-35 IU/L[2] |
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Causes of raised transaminases:
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Alkaline phosphatase (ALP); Normal value: 30–120 IU/l[2] |
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Causes of raised ALP:
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Gammaglutamyl transferase (GGT); Normal value: 0 to 30 IU/L[2] |
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Causes of raised GGT:
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Bilirubin; Normal value: 2 to 17 micromoles/L[2] |
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Causes of isolated hyperbilirubinemia:
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References[edit | edit source]
- ↑ Teshome G, Ambachew S, Fasil A, Abebe M. Prevalence of liver function test abnormality and associated factors in type 2 diabetes mellitus: a comparative cross-sectional study. Ejifcc. 2019 Oct;30(3):303.
- ↑ 2.0 2.1 2.2 2.3 Lala V, Goyal A, Bansal P, Minter D. Liver function tests. StatPearls. 2020 Apr 28.
- ↑ 3.0 3.1 3.2 3.3 Limdi JK, Hyde GM. Evaluation of abnormal liver function tests. Postgraduate medical journal. 2003 Jun 1;79(932):307-12.