Rheumatoid Arthritis Disease Activity Index (RADAI)

Original Editor - Ravi kumar

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Objective[edit | edit source]

The Rheumatoid Arthritis Disease Activity Index (RADAI-5)[1] is a simple and low-cost self-administered questionnaire that assesses disease activity in patients with Rheumatoid arthritis (RA). It aims to measure disease activity based on various patient-reported symptoms and experiences. The RADAI asks patients to rate pain in eight joint groups on a scale of 0–3. The total score ranges from 0–48. A score of 0–2.8 indicates remission, 2.9–10 indicates low disease activity, 10.1–22 indicates moderate disease activity, and a score over 22 indicates high disease activity.

Intended Population[edit | edit source]

RADAI is intended for use in individuals diagnosed with rheumatoid arthritis (RA), helping healthcare professionals assess disease activity and monitor treatment effectiveness.

Method of Use[edit | edit source]

Patients self-report their symptoms and experiences using a structured questionnaire. The questionnaire covers domains such as joint tenderness, joint swelling, pain, physical function, and overall well-being. The RADAI was comprises five items in a Likert format from 0 to 10 which is as followes-

How active was your arthritis in general during the past 6 months? 
How active is your arthritis today in terms of pressure sensitivity and swelling of the joints?
How severe is your arthritis pain today? 
How would you describe your general health? 
Were your joints stiff when you woke up today? If so, how long did this stiffness last? 

Each item is rated on a scale of 0 to 10, For items 1 and 2, 0 = “completely inactive” and 10 = “extremely active.” For item 3, 0 = “no pain” and 10 = “unbearable pain.” For item 4, 0 = “very good” health status and 10 = “very bad” health status. For item 5, 0 = “no stiffness” and 10 = “stiffness the whole day.” with higher scores indicating greater disease activity.

The result can be easily calculated: (Q1+Q2+Q3+Q4+Q5)/5

Cut-off points-[edit | edit source]

0.0–1.4 = a remission‐like state, 1.6–3.0 = mild disease activity, 3.2–5.4 = moderate disease activity, 5.6–10.0 = high disease activity

Reliability[edit | edit source]

Cronbach’s alpha Score of RADAI was 0.917[2]

Validity[edit | edit source]

The RADAI has been validated in several studies and has shown good correlation with other measures of disease activity, such as the Disease Activity Score 28 (DAS28), the Clinical Disease Activity Index (CDAI), and the Simplified Disease Activity Index (SDAI). The RADAI has also demonstrated good reliability, sensitivity to change, and responsiveness to treatment.

Responsiveness[edit | edit source]

The RADAI has shown good responsiveness to change over time and to treatment effects. The RADAI can detect clinically meaningful changes in disease activity and can reflect changes in other outcome measures.

Links[edit | edit source]

The RADAI‐5 is available free of charge. If the questionnaire is intended to be applied for scientific reasons or in a clinical trial, it is recommended to contact the developers.[3]

References[edit | edit source]

  1. Fransen J, Langenegger T, Michel BA, Stucki G. Feasibility and validity of the RADAI, a self‐administered rheumatoid arthritis disease activity index. Rheumatology. 2000 Mar 1;39(3):321-7.
  2. Leeb BF, Haindl PM, Maktari A, Nothnagl T, Rintelen B. Patient-centered rheumatoid arthritis disease activity assessment by a modified RADAI. The Journal of Rheumatology. 2008 Jul 1;35(7):1294-9.
  3. Stucki G, Liang MH, Stucki S, Brühlmann P, Michel BA. A self‐administered rheumatoid arthritis disease activity index (RADAI) for epidemiologic research. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 1995 Jun;38(6):795-8. https://pubmed.ncbi.nlm.nih.gov/7779122/