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...therapy. 2011 Oct 1;91(10):1542-50. </ref> [[Central Sensitisation|Central sensitization]] is characterized by amplification or increased sensory perception, where *Tizanidine may improve the inhibitory function in the central nervous system and can provide pain relief. Therapy with tizanidine is not

...lting from vertebral collapse due to bony metastatic disease involving the central nervous system<ref name=":2" />. ...mechanisms. There is increased sensitivity of higher-order neurons of the central nervous system, which causes pain in the absence of a peripheral nociceptiv

...ed both locally and distally in the upper and lower limbs, suggesting that central changes occur with chronic cervical pain. ...js J. [https://link.springer.com/article/10.1007/s10067-006-0433-9 Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with

...le from: [https://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1698#Sensitization https://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1698#Pain] (acc ...holds for excitation and sensitization, thereby potentially maximizing the central effects of tissue-damaging inputs.<ref name=":0" />

...by a "gatelike" process in the dorsal horn before being transferred to the central nervous system. <ref>Galik, E., Fukudo, S., Tanaka, Y., Gidron, Y., Campbel * Slight improvement in central sensitization

** can lead to the development of central sensitisation ...=":2">Volcheck MM, Graham SM, Fleming KC, Mohabbat AB, Luedtke CA. Central sensitization, chronic pain, and other symptoms: Better understanding, better management.

...nsity, duration and direction. It is the [[Central Nervous System Pathways|central nervous system (CNS)]] which interprets the activity of the different recep * Sensitization exercises (temperature, vibration, textures etc.)

...ID 18583048</ref>&nbsp;Nociception&nbsp;refers to a signal arriving at the central nervous system as a result of the stimulation of specialised sensory recept ...ude of the response for a given stimulus, a phenomenon known as peripheral sensitization. Of particular interest is the heat responsive, but mechanically insensitiv

...sitisation|Central Sensitization]] is sensitization of the dorsal horn and central structures that causes secondary hyperalgesia in the uninjured tissue aroun ...omplex system that includes the [[balance]] component of the inner ear and central nervous system structures. It's primary functions are to sense linear and a

...en, L., Simons, D. G., Pareja, J. A. (2007). Myofascial trigger points and sensitization: an updated pain model for tension‐type headache. Cephalalgia, 27(5), 383 ...o the active trigger point location. This is explained by the effects of [[Central Sensitisation]] and each trigger point has its own referral zone.

...that there is damage/disruption to the central inhibitory pathways and/or sensitization of peripheral nerves within the detrusor that trigger the micturition refle

* Central sensitisation ...|peripheral sensitisation]] may eventually lead to [[Central Sensitisation|central sensitisation]]. Therefore, detecting and managing peripheral sensitisation

...ary afferent nociceptors can be active without experiencing pain. When the central or peripheral neural systems have been damaged, several occurrences take pl ==== Central nervous system pain pathways ====

#Central sensitization with mainly positive symptoms such as hyperalgesia #Peripheral nerve sensitization with enhanced nerve trunk mechanosensitization

...rigger points suggestive of peripheral and [[Central Sensitisation|central sensitization]]<ref>Ortiz-Comino L, Fernández-Lao C, Castro-Martín E, Lozano-Lozano M,

.... Bilateral widespread mechanical pain hypersensitivity as sign of central sensitization in patients with cluster headache. Headache [Internet]. 2011 Mar [cited 201 ...es in a way that indicates autonomic (parasympathetic and sympathetic) and central nervous system involvement in CH.<ref name="Goodman" /><br>

...pread pressure pain hyperalgesia in patients after surgery, which suggests central spreading sensitisation, there were no significant differences between pati ...e]. BMC neurology. 2012;12(1):1-9.</ref> found that 27 of 40 patients with central post-stroke pain had MPS (i.e. 67.5%).

...i.com/1422-0067/23/20/12164 Pain Management and Rehabilitation for Central Sensitization in Temporomandibular Disorders: A Comprehensive Review.] International Jour

...lso sedatives and tranquillizers can be used. Those can lessen the central sensitization of the biomechanical stress. They can also help relieving the night pain wh

...’s understanding of pain neurophysiology including nociception and central sensitization, as well as, understanding their thoughts and beliefs regarding their sympt