Medication and Falls: Difference between revisions

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== What is a Fall?  ==
== What is a Fall?  ==


== What is Polypharmacy? ==
== What is Polypharmacy? ==


== Medications Associated with Increased Risk of Falls  ==
== Medications Associated with Increased Risk of Falls  ==


{| border="1" cellspacing="1" summary="Adapted from The FallSafe Project" cellpadding="1" width="900" align="left"
|+ Psychotropic Drugs and Falls Risk<ref name="FallSafe">Darowski A. Dwight J. Reynolds J. Medicines and Falls in Hospital: Guidance Sheet [ONLINE] available from https://www.rcplondon.ac.uk/sites/default/files/documents/medicines-and-falls2.pdf date accessed 14/01/2015</ref>
|-
| '''Medication Group'''
| '''Overall Risk Category'''
| '''Commonly Used Medications'''
| '''Effects on Risk'''
|-
| Sedatives
|
<u>'''''HIGH&nbsp;RISK'''''</u>
Can cause falls alone
|
Lorazepam, Temazepam, Nitrazepam
similar '''''-epam'''''suffix
| Drowsiness, slows reactions, impaired balance.
|-
| Sedating Antidepressants
|
'''<u>''HIGH&nbsp;RISK''</u>'''
Can cause falls alone
| Amitriptyline, Nortriptyline
| Orthostatic hypotension, drowsiness, slow reactions. '''DOUBLE&nbsp;THE&nbsp;RATE&nbsp;OF&nbsp;FALLS'''
|-
| Monoamine Oxidase Inhibitors
|
'''<u>''HIGH&nbsp;RISK''</u>'''
Can cause falls alone
| Phenelzine, Moclobemide
| Severe orthostatic hypotension
|-
| For Psychosis Agitation
|
'''<u>''HIGH&nbsp;RISK''</u>'''
Can cause falls alone
| Haloperidol, Chlorpromazine, Olanzapine
| Orthostatic hypotension, slow reflexes, loss of balance
|-
| Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin and Noradrenaline Reuptake Inhibitor )SNRI)
|
'''<u>''MODERATE&nbsp;RISK''</u>'''
Can cause falls in combination
| Fluoxetine, Sertaline, Paroxetine, Venlafaxine, Duloetine
| Increased risk of falls with fractures, orthostatic hypotension, bradycardia, impaired sleep quality
|-
| Opiate Analegsics
|
''<u>'''HIGH RISK'''</u>''<u></u>
Can cause falls alone<br>
| Codeine, Morphine, Tramadol
| Sedates, slows reactions, impairs balance, delirium
|-
| Anti Epileptics
| '''<u>''HIGH&nbsp;RISK''</u>'''
| Phenytoin, Carbamazepine, Phenobarbitone
| Cerebellar damage, ataxia, slowed reactions
|-
|
| '''<u>''MODERATE&nbsp;RISK''</u>'''
| Sodium Valporate, Gabapentin
| Some association with falls risk
|-
| Parkinson's Disease - Dopamine Agonists
| '''<u>''HIGH&nbsp;RISK''</u>'''
| Roprinerole, Pramipexole
| Delirium, orthostatic hypotension
|-
| Parkinson's Disease - MAOI-B Inhibitors
| '''<u>''HIGH&nbsp;RISK''</u>'''
| Selegiline
| Orthostatic hypotension (Difficult to assess due to high falls risk in PD as the disease process)
|-
| Muscle Relaxant
| '''<u>''MODERATE&nbsp;RISK''</u>'''
| Baclofen
| Reduced muscle tone, sedative
|-
| Vestibular Sedative
| '''<u>''POSSIBLE&nbsp;CAUSES''</u>'''
| Prochlorperazine, Cinnarazine, Betahistine
| Prochlor... - Dopamine agonist which may cause movement disorder in long term, sedating
|-
| Anticholinergics acting on Bladder
| '''<u>''POSSIBLE&nbsp;CAUSES''</u>'''
| Oxybutinin, Solifenacin, Tolterodine, Solifenacin
| Known CNS effects.
|}
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== Recent Related Research (from [http://www.ncbi.nlm.nih.gov/pubmed/ Pubmed])  ==
== Recent Related Research (from [http://www.ncbi.nlm.nih.gov/pubmed/ Pubmed])  ==

Revision as of 14:16, 14 January 2015

What is a Fall?[edit | edit source]

What is Polypharmacy?[edit | edit source]

Medications Associated with Increased Risk of Falls[edit | edit source]

Psychotropic Drugs and Falls Risk[1]
Medication Group Overall Risk Category Commonly Used Medications Effects on Risk
Sedatives

HIGH RISK

Can cause falls alone

Lorazepam, Temazepam, Nitrazepam

similar -epamsuffix

Drowsiness, slows reactions, impaired balance.
Sedating Antidepressants

HIGH RISK

Can cause falls alone

Amitriptyline, Nortriptyline Orthostatic hypotension, drowsiness, slow reactions. DOUBLE THE RATE OF FALLS
Monoamine Oxidase Inhibitors

HIGH RISK

Can cause falls alone

Phenelzine, Moclobemide Severe orthostatic hypotension
For Psychosis Agitation

HIGH RISK

Can cause falls alone

Haloperidol, Chlorpromazine, Olanzapine Orthostatic hypotension, slow reflexes, loss of balance
Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin and Noradrenaline Reuptake Inhibitor )SNRI)

MODERATE RISK

Can cause falls in combination

Fluoxetine, Sertaline, Paroxetine, Venlafaxine, Duloetine Increased risk of falls with fractures, orthostatic hypotension, bradycardia, impaired sleep quality
Opiate Analegsics

HIGH RISK

Can cause falls alone

Codeine, Morphine, Tramadol Sedates, slows reactions, impairs balance, delirium
Anti Epileptics HIGH RISK Phenytoin, Carbamazepine, Phenobarbitone Cerebellar damage, ataxia, slowed reactions
MODERATE RISK Sodium Valporate, Gabapentin Some association with falls risk
Parkinson's Disease - Dopamine Agonists HIGH RISK Roprinerole, Pramipexole Delirium, orthostatic hypotension
Parkinson's Disease - MAOI-B Inhibitors HIGH RISK Selegiline Orthostatic hypotension (Difficult to assess due to high falls risk in PD as the disease process)
Muscle Relaxant MODERATE RISK Baclofen Reduced muscle tone, sedative
Vestibular Sedative POSSIBLE CAUSES Prochlorperazine, Cinnarazine, Betahistine Prochlor... - Dopamine agonist which may cause movement disorder in long term, sedating
Anticholinergics acting on Bladder POSSIBLE CAUSES Oxybutinin, Solifenacin, Tolterodine, Solifenacin Known CNS effects.

 














 

 

 

 

 










 

 


Recent Related Research (from Pubmed)[edit | edit source]

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References[edit | edit source]

  1. Darowski A. Dwight J. Reynolds J. Medicines and Falls in Hospital: Guidance Sheet [ONLINE] available from https://www.rcplondon.ac.uk/sites/default/files/documents/medicines-and-falls2.pdf date accessed 14/01/2015