Myasthenia Gravis
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Definition[edit | edit source]
Myasthenia Gravis is a relatively rare anautoimmune neuromuscular disease leading to fluctuating muscle weakness and fatigue. Muscle weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction,inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors at neuromuscular junctions.[1]
Clinically Relevant Anatomy
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This is a detailed view of a neeuromuscular junction.
1. Presynaptic terminal
2. Sarcolemma
3. Synaptic vesicle
4. Nicotinic acetylcholine receptor
5. Mitochondrion
Mechanism of Injury / Pathological Process
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In Myasthenia gravis (MG) antibodies form against nicotinic acetylcholine (ACh) postsynaptic receptors at the neuromuscular junction (NMJ) of the skeletal muscles[2].The basic pathology is a reduction in the number of ACh receptors (AChRs) at the postsynaptic muscle membrane brought about by an acquired autoimmune reaction producing anti-AChR antibodies[3].
Clinical Presentation[edit | edit source]
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Outcome Measures[edit | edit source]
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Management / Interventions
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Differential Diagnosis
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Resources
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References[edit | edit source]
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- ↑ http://en.m.wikipedia.org/wiki/Myasthenia_gravis
- ↑ Strauss AJL, Seigal BC, Hsu KC. Immunofluorescence demonstration of a muscle binding complement fixing serum globulin fraction in Myasthenia Gravis. Proc Soc Exp Biol. 1960;105:184
- ↑ Patric J, Lindstrom JM. Autoimmune response to acetylcholine receptor. Science. 1973;180:871
