Tendon Biomechanics

Original Editors - Evan Thomas

Top Contributors - Evan Thomas, Lucinda hampton, Simisola Ajeyalemi, Kim Jackson, Wanda van Niekerk, 127.0.0.1, Admin, WikiSysop, Claire Knott and Rucha Gadgil

Tendon Structure, Composition, and Mechanical Properties[edit | edit source]

Physiological Mechanoresponses[edit | edit source]

Pathological Mechanoresponses[edit | edit source]

The Differential Effects of Mechanical Loading on Tendons[1][edit | edit source]

Mechanical Load Level Effects on Tendon

Low

• ↓ Tensile strength
• ↓ Size
• ↓ Collagen production
• ↓ Anabolic activities
• ↑ Catabolic activities

Moderate

• ↑ Tensile strength
• ↑ Collagen synthesis
• ↓ Collagen degradation
• ↓ Adhesions
• ↓ Inflammatory mediator (e.g. prostaglandin E2, PGE2)
• ↑ Tendon stem cells (TSCs) differentiating into tenocytes

Excessive

• ↓ Tensile strength
• ↓ Collagen organization
• ↑ Myofibroblasts
• ↑ Inflammatory mediators
• ↑ TSCs differentiating into nontenocytes (adipocytes, osteocytes, chondrocytes)
• ↑ Leukotrienes (↑ edema)


Recent Related Research (from Pubmed)[edit | edit source]

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References[edit | edit source]

  1. ↑ Wang JHC, Guo Q, Li B. Tendon Biomechanics and Mechanobiology - A Minireview of Basic Concepts and Recent Advancements. J Hand Ther, 2012; 25(2): 133–141.


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