Whipple Disease: Difference between revisions
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== Introduction == | == Introduction == | ||
Whipple's disease is a rare, chronic, systemic infectious disorder caused by a gram-positive intracellular bacterium, Tropheryma whipplei (TW).<ref>El-Abassi R, Soliman MY, Williams F, England JD. [https://www.sciencedirect.com/science/article/pii/S0022510X17300497 <nowiki>Whipple’s disease. J Neurol Sci [Internet]</nowiki>]. 2017;377:197–206. </ref><ref>Tison A, Preuss P, Leleu C, Robin F, Le Pluart A, Vix J, et al. [https://www.nature.com/articles/s41598-021-91671-9 <nowiki>Rheumatological features of Whipple disease. Sci Rep [Internet].</nowiki>] 2021;11(1):12278. </ref>The disorder can affect any system in the body but most commonly with prominent intestinal manifestations.<ref>1. | |||
[https://www.ninds.nih.gov/health-information/disorders/whipples-disease Whipple’s Disease] [Internet]. National Institute of Neurological Disorders and Stroke. </ref> The patient exhibits the classically described signs of malabsorption caused by gastrointestinal colonization. However, it can exhibit clinically overlapping signs and symptoms with rheumatic diseases, potentially leading to misdiagnosis.<ref>Kukull B, Mahlow J, Hale G, Perry LJ. [https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2020.237 <nowiki>Whipple’s disease: a fatal mimic. Autops Case Rep [Internet].</nowiki>] 2021;11:e2020237. </ref> | |||
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Revision as of 16:38, 24 September 2023
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Introduction[edit | edit source]
Whipple's disease is a rare, chronic, systemic infectious disorder caused by a gram-positive intracellular bacterium, Tropheryma whipplei (TW).[1][2]The disorder can affect any system in the body but most commonly with prominent intestinal manifestations.[3] The patient exhibits the classically described signs of malabsorption caused by gastrointestinal colonization. However, it can exhibit clinically overlapping signs and symptoms with rheumatic diseases, potentially leading to misdiagnosis.[4]
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References[edit | edit source]
- ↑ El-Abassi R, Soliman MY, Williams F, England JD. Whipple’s disease. J Neurol Sci [Internet]. 2017;377:197–206.
- ↑ Tison A, Preuss P, Leleu C, Robin F, Le Pluart A, Vix J, et al. Rheumatological features of Whipple disease. Sci Rep [Internet]. 2021;11(1):12278.
- ↑ 1. Whipple’s Disease [Internet]. National Institute of Neurological Disorders and Stroke.
- ↑ Kukull B, Mahlow J, Hale G, Perry LJ. Whipple’s disease: a fatal mimic. Autops Case Rep [Internet]. 2021;11:e2020237.
