Management of Thoracic Outlet Syndrome

Welcome to Texas State University's Evidence-based Practice project space. This is a wiki created by and for the students in the Doctor of Physical Therapy program at Texas State University - San Marcos. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!

Original Editors

Lead Editors - Your name will be added here if you are a lead editor on this page.  Read more.

Search Strategy

add text here related to databases searched, keywords, and search timeline

Definition/Description

The term ‘thoracic outlet syndrome’ (TOS) was originally coined in 1956 by RM Peet to indicate compression of the neurovascular structures in the interscalene triangle corresponding to the possible etiology of the symptoms. Since Peet provided this definition, the condition has emerged as one of the most controversial topics in musculoskeletal medicine and rehabilitation.2 This controversy extends to almost every aspect of the pathology including the definition, incidence, pathoanatomical contributions, diagnosis and treatment. Controversy with this diagnosis begins with the definition because the term TOS only outlines the location of the problem without actually defining what comprises the problem.2 TOS encompasses a wide range of clinical manifestations due to compression of nerves and vessels during their passage through the cervicothoracobrachial region.

Investigators have named two main categories of TOS: vascular forms (arterial or venous) which raise few diagnostic problems, and ‘‘neurological’’ forms, which are by far the most frequent as they represent more than 95% of all cases of TOS. The ‘‘neurological forms’’ are classified in the ‘‘true’’ neurological form associated with neurological deficits (mostly muscular atrophy), and disputed neurological forms (with no objective neurological deficit).1 The disputed neurological forms are another to blame for controversy of this topic due to the absence of objective criteria to confirm the diagnosis.

Epidemiology/Etiology

add text here

Characteristics/Clinical Presentation

Signs and symptoms of thoracic outlet syndrome are variable from patient to patient due to the location of nerve and/or vascular involvement. Symptoms range from mild pain and sensory changes to limb threatening complications in severe cases. Patients with thoracic outlet syndrome will most likely present with paresthesia in upper extremity, neck pain, trapezius pain, supraclavicular pain, chest pain, and occipital pain. Patients with upper plexus (C5,6,7) involvement can present with pain in anterior neck from the clavicle up to and including the mandible, ear, and mastoid region. These symptoms can continue into the anterior chest, scapular region, trapezius and into lateral part of the arm continuing all the way to the thumb and index finger. Patients with lower plexus (C8,T1) involvement typically present with symptoms along the medial side of the arm and hand with potential involvement in the anterior shoulder and axillary region. There are four categories of thoracic outlet syndrome and each presents with unique signs and symptoms (see Table 1). Typically thoracic outlet syndrome does not follow a dermatomal or myotomal pattern unless there is nerve root involvement which will be important in determining your PT diagnosis and planning your treatment.

Arterial TOS	Venous TOS	True TOS	Disputed Neurogenic TOS
Young adult with vigorous arm activity Pain in the hand Claudication Pallor Cold intolerance Paresthesias S/s usually appear spontaneously	Younger men with vigorous arm activity Cyanosis Feeling of heaviness Paresthesia in fingers and hand (result of edema) Edema of the arm	Hx of neck trauma Pain, paresthesia, numbness, and/or weakness Occipital headaches S/s present day and/or night Loss of fine motor skills Cold intolerance (possible Raynaud's phenomenon) Objective weakness Compressors*: s/s day>night	Hx of neck trauma Pain, paresthesia, and "feeling" of weakness Occipital headaches Nocturnal paresthesias that often wake patient Loss of fine motor skills Cold intolerance (possible Raynaud's phenomenon) Subjective weakness Releasers*: s/s night>day

Compressors* - a patient that experiences symptoms throughout the daytime while using prolonged postures resulting in increased tension or compression of the thoracic outlet

Releasers* - a patient that experiences a release phenomenon (release of tension or compression to thoracic outlet) that often awakes them at night

Differential Diagnosis

Due the variability of presentation TOS can be difficult to tease out from other pathologies with common presentations. A thorough history and evaluation must be done to determine if the patient’s symptoms are truly TOS.  The following pathologies are common differential diagnosis for TOS:

• Carpal tunnel syndrome
• DeQuervain’s tenosynovitis
• Lateral/medial epicondylitis
• Complex regional pain syndrome
• Horner’s Syndrome
• Raynaud’s disease
• Nerve root involvement

Systematic causes of brachial plexus pain include:

• Pancoast’s Syndrome
• Radiation induced brachial plexopathy
• Parsonage Turner Syndrome

Outcome Measures

DASH (Disability of Arm Shoulder and Hand)

SPADI (Shoulder Pain And Disability Index)

Examination

The following includes common examination findings seen with TOS that should be evaluated; however, this is not an all-inclusive list and examination should be individualized to the patient.

History

• Make sure to take a thorough history, clear any red flags, and ask the patient how signs/symptoms have affected his/her function.
  • Type of symptoms
  • Location and amplitude of symptoms
  • Irritability of symptoms
  • Onset and development over time
  • Aggravating/alleviating factors
  • Disability
    

Physical Examination

• Observation
  
  • Posture
  • Cyanosis
  • Edema
  • Paleness
  • Atrophy
• Palpation
  • Temperature changes
  • Supraclavicular fossa
• Neurological Screen
• MMT & Flexibility
  • Scalene
  • Pectoralis major/minor
  • Levator scapuae
  • Sternocleidomastoid
  • Serratus anterior

Special Tests

• Elevated Arm Stress
• Adson's
• Wright's
• Cyriax Release
• Supraclavicular Pressure
• Costoclavicular Maneuver
• Upper Limb Tension
• Cervical Rotation Lateral Flexion

Test	Sensitivity	Specificity	LR+	LR-
Elevated Arm Stress	52-84%	30-100%	1.2-5.2	0.4-0.53
Adson's	79%	74-100%	3.29	0.28
Wright's	70-90%	29-53%	1.27-1.49	0.34-0.57
Cyriax Release	NT	77-97%	NA	NA
Supraclavicular Pressure	NT	85-98%	NA	NA
Costoclavicular Maneuver	NT	53-100%	NA	NA
Upper Limb Tension	90%	38%	1.5	0.3
Cervical Rotation Lateral Flexion	100%	NT	NA	NA

Medical Management

Surgical management of TOS should only be considered after conservative treatment has been proven ineffective. However, limb-threatening complications of vascular TOS have been indicated for surgical intervention.

Physical Therapy Management

add text here

Key Research

add links and reviews of high quality evidence here (case studies should be added on new pages using the case study template)

Resources

add appropriate resources here

Clinical Bottom Line

add text here

Recent Related Research (from Pubmed)

see tutorial on Adding PubMed Feed

References

see adding references tutorial.